Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Timothy B. Lowinger"'
Autor:
Naniye Malli Cetinbas, Travis Monnell, Jahna Soomer-James, Pamela Shaw, Kelly Lancaster, Kalli C. Catcott, Melissa Dolan, Rebecca Mosher, Caitlin Routhier, Chen-Ni Chin, Dorin Toader, Jeremy Duvall, Raghida Bukhalid, Timothy B. Lowinger, Marc Damelin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Activating interferon responses with STING agonists (STINGa) is a current cancer immunotherapy strategy, and therapeutic modalities that enable tumor-targeted delivery via systemic administration could be beneficial. Here we demonstrate that
Externí odkaz:
https://doaj.org/article/699282d864e84cab83d32547f5f5c8e1
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak
These are figures associated with a second manuscript that has been submitted for consideration for co-publication. It describes the platform and hopefully will facilitate the reviewers' assessment of this manuscript on XMT-1536. we are also happy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5b872009cdfca855c9f02d87127d20
https://doi.org/10.1158/1535-7163.22522738
https://doi.org/10.1158/1535-7163.22522738
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak
These are figures associated with a second manuscript that has been submitted for consideration for co-publication. It describes the platform and hopefully will facilitate the reviewers' assessment of this manuscript on XMT-1536. we are happy to make
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7da7268afac65c3294d060c5e6c69b
https://doi.org/10.1158/1535-7163.22522741
https://doi.org/10.1158/1535-7163.22522741
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Peter U. Park, Qingxiu Zhang, Ling Xu, Marina Protopopova, Laura L. Poling, Michael J. DeVit, Dennis McGillicuddy, Venu R. Gurijala, Alex J. Johnson, Charlie Bu, Elena Ter-Ovanesyan, Dmitry R. Gumerov, LiuLiang Qin, Alex Uttard, Cheri A. Stevenson, Patrick R. Conlon, Susan M. Clardy, Joshua D. Thomas, Mao Yin, Natalya D. Bodyak, Aleksandr V. Yurkovetskiy
Supplementary methods, data and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650945d96b4cb4ca36cc61fe8daa399d
https://doi.org/10.1158/1535-7163.22522479
https://doi.org/10.1158/1535-7163.22522479
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f84d8d23561ce01710afb14c790013
https://doi.org/10.1158/1535-7163.22522732
https://doi.org/10.1158/1535-7163.22522732
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Peter U. Park, Qingxiu Zhang, Ling Xu, Marina Protopopova, Laura L. Poling, Michael J. DeVit, Dennis McGillicuddy, Venu R. Gurijala, Alex J. Johnson, Charlie Bu, Elena Ter-Ovanesyan, Dmitry R. Gumerov, LiuLiang Qin, Alex Uttard, Cheri A. Stevenson, Patrick R. Conlon, Susan M. Clardy, Joshua D. Thomas, Mao Yin, Natalya D. Bodyak, Aleksandr V. Yurkovetskiy
After significant effort over the last 30 years, antibody–drug conjugates (ADC) have recently gained momentum as a therapeutic modality, and nine ADCs have been approved by the FDA to date, with additional ADCs in late stages of development. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951b8c25dbbe73e1c85ae90ec75bc178
https://doi.org/10.1158/1535-7163.c.6543396
https://doi.org/10.1158/1535-7163.c.6543396
Autor:
Timothy B. Lowinger, Alex Uttard, Elena Ter-Ovanesyan, Dmitry R. Gumerov, Bangmin Zhu, LiuLiang Qin, Charles E. Hammond, Joshua D. Thomas, Cheri A. Stevenson, Natalya Bodyak, Mao Yin, Alexander V. Yurkovetskiy
Sensorgrams of trastuzumab-PHF-vinca binding the hErbB2 surfaces, ~420 RU (top) and ~1320 RU (bottom).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7346018cea49c71d286608b271914152
https://doi.org/10.1158/0008-5472.22405691.v1
https://doi.org/10.1158/0008-5472.22405691.v1
Autor:
Joshua D, Thomas, Aleksandr V, Yurkovetskiy, Mao, Yin, Natalya D, Bodyak, Dmitry R, Gumerov, Shuyi, Tang, Eoin, Kelleher, Brian D, Jones, Marina, Protopopova, LiuLiang, Qin, Alex, Uttard, Damon R, Demady, Timothy B, Lowinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128876
Pyrrolobenzodiazepine (PBD) dimers are well-known highly potent antibody drug conjugate (ADC) payloads. The corresponding PBD monomers, in contrast, have received much less attention from the ADC community. We prepared several novel polyamide-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c28732d20f05570a4c9c7504b2fae53
https://doi.org/10.1016/j.bmcl.2022.128876
https://doi.org/10.1016/j.bmcl.2022.128876
Autor:
Naniye Malli Cetinbas, Kalli C. Catcott, Travis Monnell, Jahna Soomer-James, Keith Bentley, Susan Clardy, Bingfan Du, Eoin Kelleher, Marina Protopopova, Cheri Stevenson, Joshua D. Thomas, Alex Uttard, Dorin Toader, Jeremy Duvall, Raghida Bukhalid, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 82:2114-2114
STING pathway agonism has emerged as a potential therapeutic strategy to stimulate anti-tumor immune responses. We have previously shown that tumor cell-targeted antibody-drug conjugates (ADCs) carrying a novel STING agonist induce anti-tumor activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61ff92e4fb7c9e4739a253221532097
https://doi.org/10.1158/1538-7445.am2022-2114
https://doi.org/10.1158/1538-7445.am2022-2114
Autor:
Jeremy R. Duvall, Raghida A. Bukhalid, Naniye M. Cetinbas, Kalli C. Catcott, Kelly Lancaster, Keith W. Bentley, Suzanna Clark, Susan Clardy, Scott D. Collins, Anouk Dirksen, Elizabeth Ditty, Bingfan Du, Eugene W. Kelleher, Travis Monnell, Marina Protopopova, Caitlin Routhier, Cheri Stevenson, Elena Ter-Ovanesyan, Joshua D. Thomas, Alex Uttard, Jason Wang, Phonphimon Wongthida, Ling Xu, Annika Yau, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 82:3503-3503
We present here a novel therapeutic agent, XMT-2056, that results in robust anti-tumor activity mediated by an immune response through targeted delivery of a STING agonist to the tumor microenvironment. By leveraging an antibody-drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104b7acc0fcee8f20a6655acfc9a034
https://doi.org/10.1158/1538-7445.am2022-3503
https://doi.org/10.1158/1538-7445.am2022-3503