Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Timothy B. Langston"'
Autor:
Davide Sciuscio, Florian Calvino-Martin, Ashutosh Kumar, Timothy B. Langston, Elyette Martin, Diego Marescotti, Carole Mathis, Julia Hoeng, Manuel C. Peitsch, Donna C. Smith, Maria Gogova, Patrick Vanscheeuwijck, Kyeonghee M. Lee
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Many flavor ingredients are often used in potentially reduced-risk tobacco products (such as e-vapor products). Although most are “generally recognized as safe (GRAS)” when used in food, there is limited information available on their long-term h
Externí odkaz:
https://doaj.org/article/575444b99c4b40eba0477dc9cc873fcb
Autor:
Donna C. Smith, Patrick D. Lilly, Michael S. Werley, Dan J. Kirkpatrick, Willie J. McKinney, Ann M. Jerome, Timothy B. Langston, Michael J. Oldham
Publikováno v:
Inhalation Toxicology
A prototype electronic cigaret device and three formulations were evaluated in a 90-day rat inhalation study followed by a 42-day recovery period. Animals were randomly assigned to groups for exposure to low-, mid- and high-dose levels of aerosols co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a4c4ae7b57301e58f930cfcf9f39a3
http://europepmc.org/articles/PMC4778541
http://europepmc.org/articles/PMC4778541
Autor:
Donna C. Smith, Christopher R. E. Coggins, Ann M. Jerome, Jeffery S. Edmiston, Timothy B. Langston, Erica J. Sena, Michael J. Oldham
Publikováno v:
Inhalation Toxicology. 23:41-69
A total of 32 essential oils and resins were added individually to experimental cigarettes.A battery of tests was used to compare the toxicity of mainstream smoke from these experimental cigarettes. The lowest target inclusion level was 100 ppm and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00ec762e255672289cc5b8ae89d3013
https://doi.org/10.3109/08958378.2010.543188
https://doi.org/10.3109/08958378.2010.543188
Autor:
Jason W. Flora, Timothy B. Langston, Willie J. McKinney, Gaurav S. J. B. Rana, Guoya Li, Rebecca Secrist, Jeff Edmiston
Publikováno v:
Analytical and Bioanalytical Chemistry. 391:2845-2856
Secreted proteins, the secretome, can be isolated from biological fluids (e.g., blood) and are often responsible for the regulation of biological processes such as cell signaling, growth, and apoptosis. The identification of secreted proteins can lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcbaabc251295e5f0b69197a6463f79
https://doi.org/10.1007/s00216-008-2197-3
https://doi.org/10.1007/s00216-008-2197-3
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1734:62-73
Site-directed mutagenesis of rat hepatic neutral cytosolic cholesteryl ester hydrolase (rhncCEH) was used to substitute acidic, basic or neutral amino acid residues for Ser506, required for activation by protein kinase A. The substitution of acidic A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445356a4a2be57479f936a34f44c6ab9
https://doi.org/10.1016/j.bbalip.2005.02.008
https://doi.org/10.1016/j.bbalip.2005.02.008
Publikováno v:
Lipids. 40:31-38
Hepatic neutral cytosolic cholesteryl ester hydrolase (hncCEH) is a key enzyme in the regulation of hepatic free cholesterol (FC). In examining the effects of over-expression of this enzyme on cholesterol homeostasis, mice were infected with a recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bee5497080cfa3009fbf52ceea15e7
https://doi.org/10.1007/s11745-005-1357-5
https://doi.org/10.1007/s11745-005-1357-5
Publikováno v:
Journal of Biological Chemistry. 276:33165-33174
Site-directed mutagenesis is used to identify amino acid residues that dictate reported differences in substrate specificity between rat hepatic neutral cytosolic cholesteryl ester hydrolase (hncCEH) and rat lung carboxylesterase (LCE), proteins diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9feebb8d85a9eb83b31836393e94a2f
https://doi.org/10.1074/jbc.m105644200
https://doi.org/10.1074/jbc.m105644200
Publikováno v:
Inhalation toxicology. 23
Aromatic carbonyls are typically used in the processing or flavoring of tobacco used in the manufacture of cigarettes.A battery of tests was used to compare the toxicity of mainstream smoke from experimental cigarettes containing different added leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be286af9dda3b619acbb10cb1c5170e2
https://pubmed.ncbi.nlm.nih.gov/21534858
https://pubmed.ncbi.nlm.nih.gov/21534858
Autor:
Bradley T. Webb, Timothy P. York, Jason W. Flora, Willie J. McKinney, E Lenn Murrelle, Barbara K. Zedler, Edwin J. C. G. van den Oord, Timothy B. Langston, Jeffery S. Edmiston
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 15(4)
Although cigarette smoking is recognized as the most important cause of chronic obstructive pulmonary disease (COPD), the pathophysiological mechanisms underlying the lung function decline are not well understood. Using off-line strong cation exchang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20d69577c8ebbb9ef34bc9492eb170f
https://pubmed.ncbi.nlm.nih.gov/20429838
https://pubmed.ncbi.nlm.nih.gov/20429838
Autor:
Gaurav S. J. B. Rana, Guoya Li, Jason W. Flora, Willie J. McKinney, Timothy B. Langston, Jeffery S. Edmiston, Mariano J. Scian, Tapas K. Sengupta
Publikováno v:
Analytical and bioanalytical chemistry. 394(6)
Phosphorylation is the most widely studied posttranslational modification (PTM) and is an important regulatory mechanism used during cellular responses to external stimuli. The kinases and phosphatases that regulate protein phosphorylation are known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bbbb4784e3bee6b0f47ad75c80a176
https://pubmed.ncbi.nlm.nih.gov/19479242
https://pubmed.ncbi.nlm.nih.gov/19479242