Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Timothy B. Field"'
Autor:
Julie A. Farmer, Adrian Gregory Switzer, Martin E. Dowty, Timothy B. Field, Adam W. Mazur, Xinrong Tian, Russell James Sheldon, Beth B. Pinney, Steve Berberich, Lalith R. Jayasinghe, Frank H. Ebetino, Doreen Crossdoersen, John August Wos, Cindy Obringer
Publikováno v:
Journal of Medicinal Chemistry. 49:4745-4761
The design, synthesis, and structure-activity relationships (SAR) of a series of novel proline and pyrrolidine based melanocortin receptor (MCR) agonists are described. To validate a conformationally constrained Arg-Nal dipeptide analogue strategy, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c13dd0d81d8232511803d1ceb5b3a8d
https://doi.org/10.1021/jm060384p
https://doi.org/10.1021/jm060384p
Autor:
Russell James Sheldon, Frank H. Ebetino, Doreen Crossdoersen, Beth B. Pinney, Timothy B. Field, John August Wos, Adam W. Mazur, Xinrong Tian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2819-2823
A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d98be2223eb0fbcce5b4ccf24d34b93
https://doi.org/10.1016/j.bmcl.2005.03.120
https://doi.org/10.1016/j.bmcl.2005.03.120