Genome-wide association meta-analysis of age at first cannabis use

Autor: Albertine J. Oldehinkel, Dorret I. Boomsma, Camelia C. Minică, Marco P. Boks, Jacqueline M. Vink, Iryna O. Fedko, Tamara L. Wall, Nicholas G. Martin, Michael C. Stallings, Andrew C. Heath, Michael C. Neale, Abdel Abdellaoui, Marcus R. Munafò, Kristel R. van Eijk, Christian J. Hopfer, Hans M. Koot, Tellervo Korhonen, Jean Shin, Lindsay A. Farrer, Kenneth Krauter, Joel Gelernter, Josep Antoni Ramos-Quiroga, Eske M. Derks, Vanesa Richarte, Gareth E. Davies, Ian B. Hickie, Michelle Taylor, René S. Kahn, Dominique F. Maciejewski, Iris Garcia-Martínez, Teemu Palviainen, Catharina A. Hartman, Marta Ribasés, Karin J. H. Verweij, Timothy B. Bigdeli, Margaret J. Wright, Hongyu Zhao, Ilja M. Nolte, Pamela A. F. Madden, Anu Loukola, Susan Branje, Mengzhen Liu, Richard J. Rose, Richard Sherva, Harold Snieder, Scott D. Gordon, Jennifer J. Ware, Raymond K. Walters, John K. Hewitt, Jaakko Kaprio, Manon Bernard, Hamdi Mbarek, Sandra A. Brown, Pol A. C. van Lier, Miguel Casas, Wim Meeus, Robin P. Corley, Grant W. Montgomery, Cristina Sánchez-Mora, Nathan A. Gillespie, Henry R. Kranzler, Sarah E. Medland, Zdenka Pausova, Jouke-Jan Hottenga, Penelope A. Lind, Peter J. van der Most, George Davey-Smith, Matthew Hickman, Tomáš Paus, Erik A. Ehli

Publikováno v: Addiction. 113:2073-2086

Background and aims: Cannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi-substance use and dependence. This study estimated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3811652ec4549a69e237a7b105a152da
https://doi.org/10.1111/add.14368

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

Autor: Igor Rudan, Barbara Franke, Margaret J. Wright, Juho Wedenoja, Laura J. Bierut, Anjali K. Henders, Teresa Nutile, Andrew C. Heath, Joost G. E. Janzing, Anu Realo, Ilkka Seppälä, Lindsay K. Matteson, Nicholas J. Timpson, Tõnu Esko, Arpana Agrawal, Abraham A. Palmer, Rossella Sorice, Andres Metspalu, Patrik K. E. Magnusson, Aarno Palotie, Katja Appel, Elisabeth Widen, Ozren Polasek, Katri Räikkönen, Marleen H. M. de Moor, Matthew G. Kirkpatrick, Caroline Hayward, Hans Joergen Grabe, Ian J. Deary, Nicholas G. Martin, Karin J. H. Verweij, Klaasjan G. Ouwens, Alessandra Minelli, Angelina R. Sutin, William G. Iacono, Jennifer E. Huffman, Marina Ciullo, Dorret I. Boomsma, Harry Campbell, N. L. Pedersen, David J. Porteous, Timothy B. Bigdeli, Jasper Wouda, Jun Ding, Alexander Viktorin, David C. Liewald, Gonçalo R. Abecasis, Richard A. Grucza, Carsten Oliver Schmidt, Antti Latvala, James F. Wilson, Luigi Ferrucci, Erik Pettersson, Beate St Pourcain, Scott D. Gordon, Grant W. Montgomery, Stéphanie Martine van den Berg, Jaime Derringer, Yuri Milaneschi, Alexander Teumer, Holly Trochet, Daniel E. Adkins, Jaakko Kaprio, Brenda W.J.H. Penninx, Chiara Magri, Sita H. Vermeulen, Terho Lehtimäki, Alejandro Arias Vasquez, Harriet de Wit, Jari Lahti, Jouke-Jan Hottenga, Matt McGue, Johan G. Eriksson, Daniela Ruggiero, John P. Kemp, Toshiko Tanaka, Iryna O. Fedko, Jüri Allik, Yong Qian, Annette M. Hartmann, Cornelia M. van Duijn, Barbara E. Engelhardt, Laura Pulkki-Råback, Jonathan Marten, Pamela A. F. Madden, Olli T. Raitakari, Michelle Luciano, Robert Karlsson, Amy B. Hart, Gail Davies, Liisa Keltikangas-Järvinen, Robert F. Krueger, Narelle K. Hansell, Kati Heinonen, Georg Homuth, Eero Vuoksimaa, Wendy S. Slutske, Sarah E. Medland, Andrea Maschio, Najaf Amin, John M. Starr, Antonio Terracciano, David M. Evans, Markus Jokela, Lina Zgaga, Dan Rujescu, David Schlessinger, Ina Giegling, Matthias Nauck, John M. Hettema, Evelin Mihailov, Paul T. Costa, Michael B. Miller, Bettina Konte, Minyoung Lee, George Davey Smith, Fabio Busonero, Richard J. Rose

Publikováno v: JAMA Psychiatry
JAMA Psychiatry, 72(7), 642-650. American Medical Association
JAMA Psychiatry 72 (2015): 642–650. doi:10.1001/jamapsychiatry.2015.0554
info:cnr-pdr/source/autori:Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Davey Smith G, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Penninx BW, Martin NG, Boomsma DI./titolo:Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder./doi:10.1001%2Fjamapsychiatry.2015.0554/rivista:JAMA Psychiatry/anno:2015/pagina_da:642/pagina_a:650/intervallo_pagine:642–650/volume:72
De Moor, M H M, Van Den Berg, S M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Davey Smith, G, Davies, G, De Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Råback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S, Vuoksimaa, E, Widen, E, Wouda, J, Wright, M J, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I & McGue, M 2015, ' Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder ', J A M A Psychiatry, vol. 72, no. 7, pp. 642-650 . https://doi.org/10.1001/jamapsychiatry.2015.0554
de Moor, M H M, van den Berg, S M, Verweij, C J H, Krueger, R F, Luciano, M, Arias-Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M Y, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Davey Smith, G, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Råback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S, Vuoksimaa, E, Widén, E, Wouda, J, Wright, M J, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Räikkönen, K, Wilson, J F, Keltikangas-Järvinen, L, Bierut, L J, Hettema, J M, Grabe, H J, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Penninx, B W J H, Martin, N G & Boomsma, D I 2015, ' Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder ', JAMA Psychiatry, vol. 72, no. 7, pp. 642-650 . https://doi.org/10.1001/jamapsychiatry.2015.0554
JAMA Psychiatry, 72, 642-50
JAMA psychiatry, 72(7), 642-650. American Medical Association
JAMA Psychiatry, 72, 7, pp. 642-50

Contains fulltext : 153372.pdf (Publisher’s version ) (Closed access) IMPORTANCE: Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dea846ef40199b16b4b8d4da45b6948
https://doi.org/10.1001/jamapsychiatry.2015.0554

SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE

Autor: Silviu-Alin Bacanu, Alexis C. Edwards, Kenneth S. Kendler, Bradley T. Webb, Arden Moscati, Roseann E. Peterson, Jonathan Flint, Daniel E. Adkins, Anna R. Docherty, Timothy B. Bigdeli

Publikováno v: Translational Psychiatry

Biometrical genetic studies suggest that the personality dimensions, including neuroticism, are moderately heritable (~0.4 to 0.6). Quantitative analyses that aggregate the effects of many common variants have recently further informed genetic resear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5b35d2f761ab417eaef3351624d499
http://europepmc.org/articles/PMC5290344