Výsledky vyhledávání - "Timothy B London"

Akademický článek

1024 CLN-978, a novel CD19/CD3/HSA T cell engager with extended serum half-life, is effective against lymphoma cells expressing very low levels of CD19

Autor: Agapitos Patakas, Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Kristan A Meetze, Hannah M Findlay, Timothy B London

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/f2b395f518b64e4c863b991e59b9aec8

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Akademický článek

CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression

Autor: Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)

Background Despite significant progress in the development of T cell-engaging therapies for various B-cell malignancies, a high medical need remains for the refractory disease setting, often characterized by suboptimal target levels.Methods To addres

Externí odkaz: https://doaj.org/article/03625d161242477f821871a5ae3d1af8

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