Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Timothy Alan Grese"'
Autor:
Alan David Palkowitz, Marta Pineiro-Nunez, Abdelaziz Mahoui, Timothy Alan Grese, Maria Alvim-Gaston, Ian A. Watson
Publikováno v:
Current Topics in Medicinal Chemistry. 14:294-303
The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f2aa55996b22130e8b8de32549c03e
https://doi.org/10.2174/1568026613666131127125858
https://doi.org/10.2174/1568026613666131127125858
Autor:
David Andrew Neel, Karen M. Zimmerman, Matthew L. Brown, Prabhakar Kondaji Jadhav, Robert Anthony Doti, Defauw Jean Marie, Stephon C. Smith, Peter Ambrose Lander, Sally Ann Kelley, Todd Fields, Timothy Alan Grese, Mitchell I. Steinberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2553-2557
Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1d4dba037b66ab19558a85f754cd62
https://doi.org/10.1016/j.bmcl.2005.03.086
https://doi.org/10.1016/j.bmcl.2005.03.086
Autor:
Patrick I. Eacho, Thomas P. Burris, Laura F. Michael, Patricia S. Foxworthy, Jeff McCowan, Timothy Alan Grese, William W. Chin, Kuo-Long Yu, Chahrzad Montrose, Jeffrey S. Thomas, Guoqing Cao, Anton Daniel Kiefer, Denis McCann, Kelli S. Bramlett
Publikováno v:
Journal of Biological Chemistry. 278:2403-2410
Fenofibrate is clinically successful in treating hypertriglyceridemia and mixed hyperlipidemia presumably through peroxisome proliferator-activated receptor alpha (PPARalpha)-dependent induction of genes that control fatty acid beta-oxidation. Lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5767ef1524cadc3112430d2de050575b
https://doi.org/10.1074/jbc.m209629200
https://doi.org/10.1074/jbc.m209629200
Autor:
Jeffrey Alan Dodge, Timothy Alan Grese, Henry Uhlman Bryant, Masahiko Sato, Charles H. Turner
Publikováno v:
Journal of Medicinal Chemistry. 42:1-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312adf5916703fdb0f58ffbc4fd37352
https://doi.org/10.1021/jm980344o
https://doi.org/10.1021/jm980344o
Autor:
Matthew D. Belvo, Michael Gregory Bell, Douglas Linn Gernert, V. Scott Sharp, Joseph H. Kennedy, Hannah Yu, Peter Stanley Borromeo, Timothy Alan Grese, Sally Ann Kelley, Gregory A. Stephenson, Mitchell I. Steinberg, Prabhakar Kondaji Jadhav, Jeffrey D. Williams, Karen M. Zimmerman, Rachel N. Richey, Stanley P. Kolis, Peter Ambrose Lander
Publikováno v:
Journal of Medicinal Chemistry. 50:6443-6445
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7278bc07b6e6e72013351da2997c964
https://doi.org/10.1021/jm701186z
https://doi.org/10.1021/jm701186z
Autor:
Andrew L. Glasebrook, Lorri L. Short, Harlan W. Cole, Ellen R. Rowley, James P. Sluka, David Lynn Phillips, Venugopalan M, Fuson Tr, Magee David Edward, Lewis D. Pennington, Na N. Yang, Masahiko Sato, Adrian, Timothy Alan Grese, Henry Uhlman Bryant, Pamela K. Shetler
Publikováno v:
Journal of Medicinal Chemistry. 41:1272-1283
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM) which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. In vivo structure-activity relationships and molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d5c642a524dc3cabeb566fedaf2674
https://doi.org/10.1021/jm970688z
https://doi.org/10.1021/jm970688z
Autor:
George Joseph Cullinan, Mark A. Winter, Na N. Yang, Alan David Palkowitz, Charles David Jones, John David Termine, James P. Sluka, Andrew L. Glasebrook, Timothy Alan Grese, Jeffrey Alan Dodge, Henry Uhlman Bryant, Masahiko Sato, Ken Matsumoto
Publikováno v:
Proceedings of the National Academy of Sciences. 94:14105-14110
Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand complex have been postulated to influence unique subsets of estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcbe8aadf0ca842b24538ae52e185f6
https://doi.org/10.1073/pnas.94.25.14105
https://doi.org/10.1073/pnas.94.25.14105
Autor:
Martin Michael John, Lewis D. Pennington, Andrew L. Glasebrook, Timothy Alan Grese, Ken Matsumoto, D. Lynn Phillips, Lorri L. Short
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:887-892
Methodology has been employed that permits the differentiation of the phenols of raloxifene. Transition metal mediated transformations of raloxifene triflates have subsequently provided a number of analogs that were evaluated further in two in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd7f7fd7f393e5edbe1113877fe5f6e
https://doi.org/10.1016/s0960-894x(97)00130-3
https://doi.org/10.1016/s0960-894x(97)00130-3
Autor:
Andrews L. Glasebrook, Pam K. Shetler, D. Lynn Phillips, Lorri L. Short, Magee David Edward, Harlan W. Cole, Henry Uhlman Bryant, Timothy Alan Grese
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2683-2686
The naturally occurring estrogen mimetic coumestrol has been shown to stimulate proliferation of MCF-7 mammary tumor cells and to cause uterotrophic effects in ovariectomized (OVX) rats. Attachment of a basic amine-containing sidechain to C-6 of coum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::addcd08e6e1b37705fcd10382a39cc2a
https://doi.org/10.1016/s0960-894x(96)00502-1
https://doi.org/10.1016/s0960-894x(96)00502-1
Autor:
Magee David Edward, Masahiko Sato, James P. Sluka, Timothy Alan Grese, Henry Uhlman Bryant, John Kim, Ellen R. Rowley, Harlan W. Cole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:903-908
Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and serum lipid parameters. A structural model that accounts for the pharmacological similarity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::290044bf4f517b655708578ecc76f3f2
https://doi.org/10.1016/0960-894x(96)00141-2
https://doi.org/10.1016/0960-894x(96)00141-2