Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Timothy A. Zolnik"'
Autor:
Timothy A. Zolnik, Julia Ledderose, Maria Toumazou, Thorsten Trimbuch, Tess Oram, Christian Rosenmund, Britta J. Eickholt, Robert N.S. Sachdev, Matthew E. Larkum
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3492-3505.e5 (2020)
Summary: Layer 6b (L6b), the deepest neocortical layer, projects to cortical targets and higher-order thalamus and is the only layer responsive to the wake-promoting neuropeptide orexin/hypocretin. These characteristics suggest that L6b can strongly
Externí odkaz:
https://doaj.org/article/77380060326f496f988f9474bf745aec
Autor:
Benjamien Moeyaert, Graham Holt, Rajtarun Madangopal, Alberto Perez-Alvarez, Brenna C. Fearey, Nicholas F. Trojanowski, Julia Ledderose, Timothy A. Zolnik, Aniruddha Das, Davina Patel, Timothy A. Brown, Robert N. S. Sachdev, Britta J. Eickholt, Matthew E. Larkum, Gina G. Turrigiano, Hod Dana, Christine E. Gee, Thomas G. Oertner, Bruce T. Hope, Eric R. Schreiter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Methods to directly label active neurons are still lacking. Here the authors develop CaMPARI2, a photoconvertible fluorescent protein sensor for neuronal activity with improved brightness and calcium binding kinetics, as well as an antibody to amplif
Externí odkaz:
https://doaj.org/article/0bc2383719ed4d3a919e09c4acecd7ca
Autor:
Christian Ebner, Julia Ledderose, Timothy A. Zolnik, Sina E. Dominiak, Paul Turko, Athanasia Papoutsi, Panayiota Poirazi, Britta J. Eickholt, Imre Vida, Matthew E. Larkum, Robert N. S. Sachdev
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 11 (2019)
The advent of optogenetic methods has made it possible to use endogeneously produced molecules to image and manipulate cellular, subcellular, and synaptic activity. It has also led to the development of photoactivatable calcium-dependent indicators t
Externí odkaz:
https://doaj.org/article/7017594d3fce4cf6bca006dd8fcaac43
Autor:
Martin Holtkamp, Athanasia Papoutsi, Albert Gidon, Matthew E. Larkum, Imre Vida, Timothy A. Zolnik, Panayiota Poirazi, Pawel Fidzinski, Felix Bolduan
Publikováno v:
Science
The active electrical properties of dendrites shape neuronal input and output and are fundamental to brain function. However, our knowledge of active dendrites has been almost entirely acquired from studies of rodents. In this work, we investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abbac57175e424472970e083dc22941
Autor:
Matthew E. Larkum, Robert N. S. Sachdev, Sara Moberg, Naoya Takahashi, Dieter Jaeger, Timothy A. Zolnik, Julien Catanese
Publikováno v:
Current biology : CB
Current Biology
Current Biology
SUMMARY Prompt execution of planned motor action is essential for survival. The interactions between frontal cortical circuits and the basal ganglia are central to goal-oriented action selection and initiation.1–4 In rodents, the ventromedial thala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d19585cfcb4271639d381084bfd1dd
https://doi.org/10.1016/j.cub.2021.06.089
https://doi.org/10.1016/j.cub.2021.06.089
Autor:
Loren L. Looger, Fern Sha, Matthew E. Larkum, Friedrich W. Johenning, Robert N. S. Sachdev, Eric R. Schreiter, Timothy A. Zolnik
Publikováno v:
The Journal of Physiology. 595:1465-1477
Key points The genetically encoded fluorescent calcium integrator calcium-modulated photoactivatable ratiobetric integrator (CaMPARI) reports calcium influx induced by synaptic and neural activity. Its fluorescence is converted from green to red in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78922b30a856c0a3ec8c2d3574e082e
https://doi.org/10.1113/jp273116
https://doi.org/10.1113/jp273116
Autor:
Timothy A. Zolnik, Barry W. Connors
Publikováno v:
The Journal of Physiology. 594:2579-2592
Key points The thalamus is a structure critical for information processing and transfer to the cortex. Thalamic reticular neurons are inhibitory cells interconnected by electrical synapses, most of which require the gap junction protein connexin36 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2a7ef70d187bc5cb439821b2d445823
https://doi.org/10.1113/jp271880
https://doi.org/10.1113/jp271880
Autor:
Alberto Perez-Alvarez, Davina Patel, Eric R. Schreiter, Matthew E. Larkum, Bruce T. Hope, Timothy A. Brown, Graham T. Holt, Brenna C. Fearey, Gina G. Turrigiano, Nicholas F. Trojanowski, Christine E. Gee, Hod Dana, Robert N. S. Sachdev, Britta J. Eickholt, Rajtarun Madangopal, Benjamien Moeyaert, Aniruddha Das, Timothy A. Zolnik, Julia Ledderose, Thomas G. Oertner
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Marking functionally distinct neuronal ensembles with high spatiotemporal resolution is a key challenge in systems neuroscience. We recently introduced CaMPARI, an engineered fluorescent protein whose green-to-red photoconversion depends on simultane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b7d9109924fafc36b0f58d40b9d7a0
Publikováno v:
Neuron. 67:354-357
Electrical synapses and synchrony are nearly synonymous. In this issue of Neuron , Vervaeke et al. broaden this longstanding association. They found that in the Golgi cell network of the cerebellum, electrical synapses synchronize resting activity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db94ad82875da6ba13a0b68b9d50651
https://doi.org/10.1016/j.neuron.2010.07.024
https://doi.org/10.1016/j.neuron.2010.07.024
Autor:
Rebecca D. Burwell, Tara K. Jacobson, Timothy A. Zolnik, Devon L. Poeta, Jonathan Weng-Thim Ho, Barry W. Connors, Garrett T. Neske
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(39)
Perirhinal cortex (PER) has a well established role in the familiarity-based recognition of individual items and objects. For example, animals and humans with perirhinal damage are unable to distinguish familiar from novel objects in recognition memo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13408736b31ad3ac8a0028828354384b
https://pubmed.ncbi.nlm.nih.gov/26424881
https://pubmed.ncbi.nlm.nih.gov/26424881