Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Timothy A. Vortherms"'
Autor:
Mark A. Watson, Harmanmeet Brar, Edwin T. Gibbs, Hoi-Shan Wong, Pratiksha A. Dighe, Bryan McKibben, Stephan Riedmaier, Amy Siu, James S. Polakowski, Jason A. Segreti, Xiaoqin Liu, SeungWon Chung, Y. Marina Pliushchev, Nathan Gesmundo, Zhi Wang, Timothy A. Vortherms, Martin D. Brand
Publikováno v:
Free Radical Biology and Medicine. 204:276-286
Autor:
C. Tse, Ying Jia, X. Wang, Liu Bo, Douglas M. Cyr, Torben R. Neelands, Wenqing Gao, Xenia B. Searle, Ashvani K. Singh, Timothy A. Vortherms, Hong Y. Ren, Andrew M. Swensen, Corina Balut, Arlene M. Manelli, Sara Alani, Philip R. Kym, K. Conrath, Tzyh Chang Hwang, Yihong Fan
Publikováno v:
J Pharmacol Exp Ther
Cystic fibrosis (CF) is the most common monogenic autosomal recessive disease in Caucasians caused by pathogenic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR). Significant small molecule therapeutic advances
Autor:
Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh
Publikováno v:
ACS Med Chem Lett
[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protei
Autor:
A. M. Manelli, Y. Jia, Philip R. Kym, X. Wang, Timothy A. Vortherms, S. Alani, Wenqing Gao, C. Balut, Ashvani K. Singh, Tzyh Chang Hwang, Douglas M. Cyr, H. Y. Ren, Andrew M. Swensen, Y. Fan, Torben R. Neelands, K. Conrath, C. Tse, Xenia B. Searle, Liu Bo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(3)
Autor:
Searle Xenia B, Wenqing Gao, Andrew M. Swensen, Timothy A. Vortherms, Hong Yong, Clinton Yeung, Corina Balut, Philip R. Kym, Yihong Fan, Ashvani K. Singh, Greszler Stephen N, Kelly E. Desino, Andrew Bogdan, Ying Jia, Chris Tse, Xueqing Wang, Bo Liu
Publikováno v:
Journal of Medicinal Chemistry. 61:1436-1449
Cystic fibrosis (CF) is a multiorgan disease of the lungs, sinuses, pancreas, and gastrointestinal tract that is caused by a dysfunction or deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an epithelial anion chan
Autor:
Timothy A. Vortherms, Michael F. Jarvis, Chang Z. Zhu, Daria Darczak, Jill M. Wetter, Victoria E. Scott, Chih-Hung Lee, Shashank Shekhar, Clinton M. Yeung, Michael R. Schrimpf, Patricia N. Banfor, Ivan Milicic, Kennan C. Marsh, Andrew M. Swensen, Loan N. Miller, Xenia Beebe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4857-4861
A novel series of N-type calcium channel inhibitors have been discovered. Optimization of potency and HT-ADME properties provides 4-aminocyclopentapyrrolidines with analgesic efficacy after oral dosing.
Autor:
Andrew O. Stewart, Janel M. Boyce-Rustay, Ivan Milicic, Chang Z. Zhu, Jill M. Wetter, Timothy A. Vortherms, Michael F. Jarvis, Marian T. Namovic, Diana L. Donnelly-Roberts, Chengmin Zhong, Victoria E. Scott, Karen Kage, Rodger F. Henry, Erica Gomez, Scott J. Baker, Carol S. Surowy, Daria Darczak, Pamela H. Franklin, Gricelda H. Simler, Wende Niforatos, Richard S. Janis, Andrew M. Swensen, Kennan C. Marsh, Xenia Beebe
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:4128-4139
A novel 4-aminocyclopentapyrrolidine series of N-type Ca(2+) channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectiv
Autor:
Torben R. Neelands, Andrew O. Stewart, Gricelda H. Simler, Chengmin Zhong, Andrew J. King, Chang Z. Zhu, George Doherty, Andrew M. Swensen, Ivan Milicic, Janel M. Boyce-Rustay, Cenchen Zhan, Patricia N. Banfor, Timothy A. Vortherms, Victoria E. Scott, Natalie Bratcher, Michael F. Jarvis, Wende Niforatos, Helmut Mack, Pramila Bhatia
Publikováno v:
Biochemical Pharmacology. 83:406-418
Blockade of voltage-gated Ca²⁺ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca²⁺ channel blockers that produce significant an
Autor:
James T. Limberis, Di Zhang, Torben R. Neelands, Richard S. Janis, Diana L. Donnelly-Roberts, Wende Niforatos, Timothy A. Vortherms, Carol S. Surowy, C. Brent Putman, Ruth L. Martin, Michael F. Jarvis, Marian T. Namovic, Rama Thimmapaya, Andrew M. Swensen, Victoria E. Scott
Publikováno v:
Inflammation Research. 60:683-693
The aim of this study was to compare a diverse set of peptide and small-molecule calcium channel blockers for inactivated-state block of native and recombinant N-type calcium channels using fluorescence-based and automated patch-clamp electrophysiolo
Autor:
Timothy A. Vortherms, Bryan L. Roth
Publikováno v:
Molecular Interventions. 6:257-265
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationally. The neo