Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Timothy A. Powell"'
Autor:
Amy Packer, Leena Habiballa, Esteban Tato-Barcia, Gerome Breen, Helen Brooker, Anne Corbett, Ryan Arathimos, Clive Ballard, Adam Hampshire, Abbie Palmer, Danai Dima, Dag Aarsland, Byron Creese, Margherita Malanchini, Timothy R. Powell
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
BackgroundTelomere length (TL) has been linked to cognitive function, decline and dementia. This study aimed to explore whether both measured TL and genetic disposition for TL predict dimensions of cognitive performance in a longitudinal sample of ol
Externí odkaz:
https://doaj.org/article/21f2bbaa11514ff68fcbd1ad1ed2ef17
Autor:
Rodrigo R. R. Duarte, Oliver Pain, Matthew L. Bendall, Miguel de Mulder Rougvie, Jez L. Marston, Sashika Selvackadunco, Claire Troakes, Szi Kay Leung, Rosemary A. Bamford, Jonathan Mill, Paul F. O’Reilly, Deepak P. Srivastava, Douglas F. Nixon, Timothy R. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform specialised transcriptome-wide association studies that consid
Externí odkaz:
https://doaj.org/article/b450345af2824456a3a8a93c234cbf75
Autor:
Alish B. Palmos, Rodrigo R. R. Duarte, Demelza M. Smeeth, Erin C. Hedges, Douglas F. Nixon, Sandrine Thuret, Timothy R. Powell
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Lithium is a first-line treatment for bipolar disorder, where it acts as a mood-stabilizing agent. Although its precise mechanism remains unclear, neuroimaging studies have shown that lithium accumulates in the hippocampus and that chronic u
Externí odkaz:
https://doaj.org/article/92d156481a5d4cdda0641de04bc10b0a
Autor:
Rodrigo R. R. Duarte, Dennis C. Copertino, Luis P. Iñiguez, Jez L. Marston, Yaron Bram, Yuling Han, Robert E. Schwartz, Shuibing Chen, Douglas F. Nixon, Timothy R. Powell
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-11 (2021)
Abstract Background Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial to individuals who a
Externí odkaz:
https://doaj.org/article/bce76190279a4c49ad83ba37633ed9c4
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104854- (2022)
Summary: The host genetic factors conferring protection against HIV type 1 (HIV-1) acquisition remain elusive, and in particular the contributions of common genetic variants. Here, we performed the largest genome-wide association meta-analysis of HIV
Externí odkaz:
https://doaj.org/article/54145ed61d944536a089b89e3c45b8ad
Autor:
Timothy R. Powell, Rodrigo R. R. Duarte, Matthew Hotopf, Stephani L. Hatch, Miguel de Mulder Rougvie, Gerome D. Breen, Cathryn M. Lewis, Douglas F. Nixon
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Millions are exposed to the human immunodeficiency virus type 1 (HIV-1) every year, but not all acquire the virus, suggesting a potential role for host genetics in the moderation of HIV-1 acquisition. Here, we analyzed summary statistics fro
Externí odkaz:
https://doaj.org/article/4d125614518f49bc8192fd1c6c270373
Publikováno v:
Brazilian Journal of Psychiatry, Vol 43, Iss 3, Pp 342-344 (2021)
Externí odkaz:
https://doaj.org/article/27f49ba470554a0bb8e68ffee9f56184
Autor:
Timothy R Powell, Matthew Hotopf, Stephani L Hatch, Gerome Breen, Rodrigo R R Duarte, Douglas F Nixon
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives It remains unknown how inflammatory marker levels differ amongst individuals susceptible to coronavirus disease 2019 (COVID‐19), prior to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and the onset o
Externí odkaz:
https://doaj.org/article/ab98b209c4de40e2aa54363ae343e808
Autor:
Roy M. Gulick, Rodrigo R.R. Duarte, Dennis C Copertino, Miguel de Mulder Rougvie, Timothy R. Powell, Timothy J. Wilkin, Bruno C Casado Lima, Christopher E. Ormsby, Douglas F. Nixon
Publikováno v:
Journal of biomolecular structuredynamics. 40(16)
COVID-19 is the disease caused by SARS-CoV-2 which has led to 2,643,000 deaths worldwide, a number which is rapidly increasing. Urgent studies to identify new antiviral drugs, repurpose existing drugs, or identify drugs that can target the overactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62982ec5e6a08e43ad963fd14aedca8
https://pubmed.ncbi.nlm.nih.gov/33734021
https://pubmed.ncbi.nlm.nih.gov/33734021
Autor:
Alish B. Palmos, Stuart Watson, Tom Hughes, Andreas Finkelmeyer, R. Hamish McAllister-Williams, Nicol Ferrier, Ian M. Anderson, Rajesh Nair, Allan H. Young, Rebecca Strawbridge, Anthony J. Cleare, Raymond Chung, Souci Frissa, Laura Goodwin, Matthew Hotopf, Stephani L. Hatch, Hong Wang, David A. Collier, Sandrine Thuret, Gerome Breen, Timothy R. Powell
Publikováno v:
BJPsych Open, Vol 5 (2019)
BackgroundChildhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.AimsTo determine the effects of childhood
Externí odkaz:
https://doaj.org/article/ba32019057c1460bbee994a5c0feedf1