Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Timothy A. Mann"'
Autor:
Maria George Elias, Angelico D. Aputen, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8252 (2024)
Chlorambucil-platinum(IV) prodrugs exhibit multi-mechanistic chemotherapeutic activity with promising anticancer potential. The platinum(II) precursors of the prodrugs have been previously found to induce changes in the microtubule cytoskeleton, spec
Externí odkaz:
https://doaj.org/article/2b4798a84a594134bd63ed251d1b3839
Autor:
Maria George Elias, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Publikováno v:
Cancers, Vol 16, Iss 14, p 2544 (2024)
Development of resistance to cisplatin, oxaliplatin and carboplatin remains a challenge for their use as chemotherapies, particularly in breast and colorectal cancer. Here, we compare the anticancer effect of novel complexes [Pt(1,10-phenanthroline)(
Externí odkaz:
https://doaj.org/article/186b0f5a300b4f949cec83b190249c74
Autor:
Kieran F. Scott, Timothy J. Mann, Shadma Fatima, Mila Sajinovic, Anshuli Razdan, Ryung Rae Kim, Adam Cooper, Aflah Roohullah, Katherine J. Bryant, Kasuni K. Gamage, David G. Harman, Fatemeh Vafaee, Garry G. Graham, W. Bret Church, Pamela J. Russell, Qihan Dong, Paul de Souza
Publikováno v:
Molecules, Vol 26, Iss 23, p 7267 (2021)
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in 1961. The secreted (sPLA2) enzymes were the first of the five major classes of human PLA2s to be identified and now number nine catalytically-active structurally hom
Externí odkaz:
https://doaj.org/article/eb2e06cdc5944953ae3c4aad2d98fc41
Publikováno v:
Molecules, Vol 25, Iss 19, p 4459 (2020)
Human group IIA secretory phospholipase A2 (hGIIA) promotes the proliferation of cancer cells, making it a compelling therapeutic target, but it is also significant in other inflammatory conditions. Consequently, suitable inhibitors of hGIIA have alw
Externí odkaz:
https://doaj.org/article/fc14901b466340a8a9e1de1850cf23e5
Autor:
Jamie M. Waterman, Scott N. Johnson, Susan E. Hartley, Timothy J. Mann, Christopher I Cazzonelli
Publikováno v:
Ecological Entomology. 45:1224-1229
1. Plants have long been exposed to insect herbivore attack. Crucial to the plant's ability to defend itself is its ability to identify specific signals associated with attacking insects. Distinctive chemical cues, such as those associated with chewi
Autor:
Fatemeh Vafaee, Kasuni K. Gamage, Shadma Fatima, Ryung Rae Kim, Kieran F. Scott, Pamela J. Russell, Katherine Bryant, Garry G. Graham, David G. Harman, Aflah Roohullah, W. Bret Church, Anshuli Razdan, Qihan Dong, Adam Cooper, Paul de Souza, Timothy J. Mann, Mila Sajinovic
Publikováno v:
Molecules
Molecules, Vol 26, Iss 7267, p 7267 (2021)
Molecules, Vol 26, Iss 7267, p 7267 (2021)
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in 1961. The secreted (sPLA2) enzymes were the first of the five major classes of human PLA2s to be identified and now number nine catalytically-active structurally hom
Autor:
Ivan Lobov, Anton Zhernov, Krishnamurthy Dvijotham, Natarajan Chandrashekar, Michelle Gong, Dan Andrei Calian, Timothy A. Mann
Publikováno v:
KDD
Modern recommender systems need to deal with multiple objectives like balancing user engagement with recommending diverse and fresh content. An appealing way to optimally trade these off is by imposing constraints on the ranking according to which it
Autor:
Timothy A. Mann, Po-Sen Huang, Krishnamurthy Dvijotham, Chongli Qin, Taylan Cemgil, Pushmeet Kohli, Sven Gowal
Publikováno v:
CVPR
Recent research has made the surprising finding that state-of-the-art deep learning models sometimes fail to generalize to small variations of the input. Adversarial training has been shown to be an effective approach to overcome this problem. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d24175d94da5279fe3d827bb3c8a4
http://arxiv.org/abs/1912.03192
http://arxiv.org/abs/1912.03192
Autor:
Rudy Bunel, Pushmeet Kohli, Robert Stanforth, Relja Arandjelovic, Jonathan Uesato, Sven Gowal, Krishnamurthy Dvijotham, Timothy A. Mann, Chongli Qin
Publikováno v:
ICCV
Recent work has shown that it is possible to train deep neural networks that are provably robust to norm-bounded adversarial perturbations. Most of these methods are based on minimizing an upper bound on the worst-case loss over all possible adversar