Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Timothy A. Kramer"'
Autor:
Eric L. Elliott, Rodney L. Parsons, Christopher J. Borths, Jeffrey C. Roberts, Timothy T. Kramer, John Donaubauer, Jared Evans, Michael Urquhart, Heewon Lee, Ping Zhuang, Ke Wang, Mark D. Argentine, Andrew Teasdale, Gregory W. Sluggett
Publikováno v:
Organic Process Research & Development. 25:831-837
ICH M7 provides several risk-based control options to manage mutagenic and potentially mutagenic impurities (MI and PMIs) in the manufacture of pharmaceuticals. A Working Group in the International...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dca48a49d72f650c4dacef79f44cd5e5
https://doi.org/10.1021/acs.oprd.0c00517
https://doi.org/10.1021/acs.oprd.0c00517
Publikováno v:
Statistics in Biopharmaceutical Research. 11:152-161
Advanced pharmaceutical manufacturing technologies have the potential to make substantial contributions toward reducing waste, cost, and cycle time. However, the steady introduction of advanced man...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dfb5cd8daf034fe349b7bf593c53d4b
https://doi.org/10.1080/19466315.2018.1546611
https://doi.org/10.1080/19466315.2018.1546611
Autor:
Jon Hilden, Timothy T. Kramer, John Strong, Ilgaz Akseli, Chen Mao, Jeffrey M. Katz, Frederick Osei-Yeboah, Ron C. Kelly
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1081-1084
The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4ad595e38ec36978ee02c5cb014663
https://doi.org/10.1016/j.xphs.2018.10.009
https://doi.org/10.1016/j.xphs.2018.10.009
Publikováno v:
Journal of Chromatography A. 1489:65-74
Based on a column-screening exercise, a column ranking system was developed for sample mixtures containing any combination of 26 sugar and sugar alcohol analytes using 16 polar stationary phases in the HILIC mode with acetonitrile/water or acetone/wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4622d938ef69e1330ee1d282149c0b72
https://doi.org/10.1016/j.chroma.2017.01.072
https://doi.org/10.1016/j.chroma.2017.01.072
Publikováno v:
Journal of pharmaceutical sciences. 108(5)
Degradation rates of solid-state drug products generally increase as the drug load decreases. A model for quantifying this effect based on surface area ratios is proposed here. This model relates the degradation rate to an estimate of the proportion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e4f9994f3edae834d7f26fcf462911
https://pubmed.ncbi.nlm.nih.gov/30550816
https://pubmed.ncbi.nlm.nih.gov/30550816
Autor:
Sze Wing Wong, Steven J. Doherty, Mark A. LaPack, Norma Scully, Zhenqi Shi, Gordon R. Lambertus, Robert A. Forbes, James Hermiller, Timothy T. Kramer
Publikováno v:
Applied Spectroscopy. 68:445-457
An on-line analytical method based on transmission near-infrared spectroscopy (NIRS) for the quantitative determination of water concentrations (in parts per million) was developed and applied to the manufacture of a pharmaceutical intermediate. Cali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76f79d8f7e38b9eac7c69e04476575f
https://doi.org/10.1366/13-07260
https://doi.org/10.1366/13-07260
Publikováno v:
Journal of pharmaceutical sciences. 106(5)
The purpose of this work was to assess the impact of continuous mixing on tablet critical quality attributes (CQAs) manufactured using a continuous, direct compression process. A 9-run design of experiments (DoE) that bracketed the range of commercia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea60fe475a8c0e47800528f373f7e4dc
https://pubmed.ncbi.nlm.nih.gov/28153598
https://pubmed.ncbi.nlm.nih.gov/28153598
Publikováno v:
Ecosystems. 15:1271-1282
The composition of plant communities everywhere now likely comprises alien as well as native species, and those aliens that become invasive have wide-ranging impacts on the structure and function of recipient ecosystems. These impacts include perturb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27511cdf4199e4e3504cb7cfd65ef8df
https://doi.org/10.1007/s10021-012-9583-6
https://doi.org/10.1007/s10021-012-9583-6
Publikováno v:
Biological Invasions. 14:2625-2637
Exotic plant invasion not only changes native plant communities, it also alters associated arthropod community diversity and structure. These impacts often are contradictory and context-specific by study location. M. vimineum is an Asian grass curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faae699546918f314deac9714df43a05
https://doi.org/10.1007/s10530-012-0258-1
https://doi.org/10.1007/s10530-012-0258-1
Autor:
Sung Hyuk Park, Dong Suk Han, Bill Batchelor, Timothy A. Kramer, Ahmed Abdel-Wahab, Chunwoo Lee
Publikováno v:
Advances in environmental research. 1:37-55
Here we show that perchlorate reduction during pitting corrosion of zero-valent titanium (ZVT) is likely caused by dissolved titanium species, especially Ti(II). Several possible mechanisms were suggested based on the literature and were evaluated ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e88aa5f08d0a56d3076a6a3117134e1
https://doi.org/10.12989/aer.2012.1.1.037
https://doi.org/10.12989/aer.2012.1.1.037