Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy A. Grieme"'
Autor:
Rajeev M. Menon, Timothy A. Grieme, Yemin Liu, Ahmed Salem, Jeffrey Bien, David Rizzo, Lutz R. Asmus, Tricia Elkinton, Amr Alaarg
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 15, Iss 1, Pp 244-254 (2022)
Clinical and Translational Science, Vol 15, Iss 1, Pp 244-254 (2022)
This work presents an end‐to‐end approach for assessing the absolute bioavailability of highly hydrophobic, poorly water‐soluble compounds that exhibit high nonspecific binding using venetoclax as a model drug. The approach utilizes a stable la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f54b61cec8db57c9b30c9ca609f204
http://europepmc.org/articles/PMC8742638
http://europepmc.org/articles/PMC8742638
Autor:
Kaid C. Harper, Yi-Yin Ku, Srinivas Grangula, Jeremy Griffin, Jia-long Yuan, Ning-ning Zhang, James R. Gage, Timothy Towne, Ping-zhong Huang, Song-yuan Zheng, Daniel J. Mack, Moiz Diwan, En-xuan Zhang, Robert W. Miller, Zhi-qing Liu, Timothy A. Grieme
Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow. In this report, a photoredox trifluoromethylation of a thiophenol was modified from the origina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a56e0229b56d06c2c27415db437cd5
https://doi.org/10.33774/chemrxiv-2021-z3xm8-v2
https://doi.org/10.33774/chemrxiv-2021-z3xm8-v2
Autor:
Daniel D. Caspi, Kenneth M. Engstrom, Seble H. Wagaw, Nandkishor K. Nere, Dean S. Clyne, Clifford Mitchell, Timothy A. Grieme, Ahmad Y. Sheikh, Jianzhang Mei, Moiz Diwan, Hongqiang Zhang, Robert W. Miller, Russell D. Cink, Matthew M. Ravn, José G. Napolitano
Publikováno v:
Tetrahedron. 75:4271-4286
ABT-450 (8), a potent hepatitis C (HCV) NS3/4A protease inhibitor, was approved as part of AbbVie's first generation HCV treatment for the United States in December 2014. A series of process optimizations were developed over six years to support the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3474018a8bbe12903d6fc0b66dec7400
https://doi.org/10.1016/j.tet.2019.05.064
https://doi.org/10.1016/j.tet.2019.05.064
Autor:
Yu-Ming Pu, Yi-Yin Ku, Vincent S. Chan, Michael D. Wendt, Timothy A. Grieme, Alan Christesen, Mathew M. Mulhern
Publikováno v:
The Journal of Organic Chemistry. 84:4814-4829
The process development of a new synthetic route leading to an efficient and robust synthetic process for venetoclax (1: the active pharmaceutical ingredient (API) in Venclexta) is described. The redesigned synthesis features a Buchwald-Hartwig amina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d73ed1e6451b285f5cf09ec6364e62
https://doi.org/10.1021/acs.joc.8b02750
https://doi.org/10.1021/acs.joc.8b02750
Publikováno v:
Organic Process Research & Development. 16:1994-2000
During the process safety analysis of a fluoride displacement reaction, a highly exothermic event was observed when the reaction mixture was heated, which appears to be due to the decomposition of DMSO catalyzed by the HF byproduct from the displacem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ac6d91deeb7c8ca7a4607429582c5a
https://doi.org/10.1021/op300016m
https://doi.org/10.1021/op300016m
Autor:
Yu-Ming Pu, Timothy A. Grieme, Marlon D. Cowart, Yi-Yin Ku, Ashok V. Bhatia, Lawrence A. Black
Publikováno v:
Organic Process Research & Development. 11:1004-1009
A facile and scaleable synthesis of potent and selective histamine H3 receptor antagonist 1 is described, starting from commercially available 6-bromo-naphthalene-2-carboxylic acid methyl ester 3a. The key intermediate, 2-(6-bromonaphthalen-2-yl)etha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8392b8a3ae0866df4bb6dc06a34f4b5b
https://doi.org/10.1021/op700102k
https://doi.org/10.1021/op700102k
Autor:
Ashok K. Gupta, Yu-Ming Pu, Ashok V. Bhatia, Daniel J. Plata, Marlon Cowart, Timothy A. Grieme, Yi-Yin Ku
Publikováno v:
Organic Process Research & Development. 9:45-50
A facile and scaleable synthesis of a potent and selective histamine H3 receptor antagonist, ABT-239 (1), was developed starting from commercially available 4‘-hydroxy-biphenyl-4-carbonitrile (2). The synthesis comprised four chemical steps and a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76aa12a7e085dfbfe212406cb0b4cf4f
https://doi.org/10.1021/op049809c
https://doi.org/10.1021/op049809c