Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Timothy A. Graubert"'
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Autor:
Terrence N. Wong, Christopher A. Miller, Matthew R. M. Jotte, Nusayba Bagegni, Jack D. Baty, Amy P. Schmidt, Amanda F. Cashen, Eric J. Duncavage, Nichole M. Helton, Mark Fiala, Robert S. Fulton, Sharon E. Heath, Megan Janke, Kierstin Luber, Peter Westervelt, Ravi Vij, John F. DiPersio, John S. Welch, Timothy A. Graubert, Matthew J. Walter, Timothy J. Ley, Daniel C. Link
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
Externí odkaz:
https://doaj.org/article/a452ad93f9a248dab38fccf1d7384184
Autor:
Cara Lunn Shirai, Brian S. White, Manorama Tripathi, Roberto Tapia, James N. Ley, Matthew Ndonwi, Sanghyun Kim, Jin Shao, Alexa Carver, Borja Saez, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Chandraiah Lagisetti, Thomas R. Webb, Timothy A. Graubert, Matthew J. Walter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Spliceosome mutations occur in approximately 50% of patients with myelodysplastic syndromes. Here, the authors show that tumour cells harbouring theS34F mutation in the U2AFspliceosome gene is sensitive to compounds that further perturb the spliceoso
Externí odkaz:
https://doaj.org/article/58561889db084efca98a8125161aeb78
Autor:
Andrew M. Brunner, Timothy A. Graubert
Publikováno v:
HemaSphere, Vol 2, Pp 150-152 (2018)
Externí odkaz:
https://doaj.org/article/5ebac08de08d471f80bccaaf3d36f744
Autor:
Amir T. Fathi, Seth A. Wander, Traci M. Blonquist, Andrew M. Brunner, Philip C. Amrein, Jeffrey Supko, Nicole M. Hermance, Amity L. Manning, Hossein Sadrzadeh, Karen K. Ballen, Eyal C. Attar, Timothy A. Graubert, Gabriela Hobbs, Christelle Joseph, Ashley M. Perry, Meghan Burke, Regina Silver, Julia Foster, Meghan Bergeron, Aura Y. Ramos, Tina T. Som, Kaitlyn M. Fishman, Kristin L. McGregor, Christine Connolly, Donna S. Neuberg, Yi-Bin Chen
Publikováno v:
Haematologica, Vol 102, Iss 4 (2017)
Aberrant expression of aurora kinase A is implicated in the genesis of various neoplasms, including acute myeloid leukemia. Alisertib, an aurora A kinase inhibitor, has demonstrated efficacy as monotherapy in trials of myeloid malignancy, and this ef
Externí odkaz:
https://doaj.org/article/3505135afba4471f95cb8a4b2bb74035
Autor:
Anthony Hunter, Hannah Newman, Eric Solary, Klaus Geissler, Laura Palomo, Lurdes Zamora, Francesc Solé, Valeria Santini, Timothy A. Graubert, Swapna Thota, Elizabeth A. Griffiths, Lisa Pleyer, Felicitas R. Thol, Rafael Bejar, Luis E. Aguirre, David A. Sallman, Andrew Kuykendall, Rami S. Komrokji, Tracy I. George, Eric Padron
Publikováno v:
Blood. 140:9824-9827
Autor:
Sayantani Sinha, Zhiyan Silvia Liu, Maxwell Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Martina Sarchi, Elizabeth Bonner, Victor Corral, Cassandra Leibson, Wannasiri Chiraphapphaiboon, Derek Stirewalt, Joachim Deeg, Sumit Rai, Matthew J Walter, Timothy A. Graubert, Sergei Doulatov, Dang Hai Nguyen, Stanley Chun-Wei Lee
Publikováno v:
Blood. 140:217-219
Autor:
Amir T. Fathi, Geoffrey G Fell, Areej El-Jawahri, Alexander E. Perl, Brian A. Jonas, Ajoy L. Dias, Alice S. Mims, Uma Borate, Brittany Knick Ragon, Michael R. Grunwald, Mary Linton B. Peters, Timothy A. Graubert, Philip C. Amrein, Hanno R. Hock, Andrew M. Brunner, Gabriela S. Hobbs, Rupa Narayan, Donna S. Neuberg, Ibrahim Aldoss
Publikováno v:
Blood. 140:3284-3286
Autor:
Timothy A. Graubert, Lee Zou, Matthew J. Walter, Jack D. Sullivan, Pavankumar N.G. Reddy, Weiling Li, Wan Yee Leong, Hai Dang Nguyen
Heterozygous somatic mutations in spliceosome genes (U2AF1, SF3B1, ZRSR2, or SRSF2) occur in >50% of patients with myelodysplastic syndrome (MDS). These mutations occur early in disease development, suggesting that they contribute to MDS pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43692d29371488397239ee10318196b
https://doi.org/10.1158/0008-5472.c.6510369.v1
https://doi.org/10.1158/0008-5472.c.6510369.v1
Autor:
Timothy A. Graubert, Lee Zou, Matthew J. Walter, Jack D. Sullivan, Pavankumar N.G. Reddy, Weiling Li, Wan Yee Leong, Hai Dang Nguyen
U2AF1(S34F)-expressing cells induce R loop-associated ATR-mediated RPA32 phosphorylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cd3d3e832d134a79b182d8b32a3af7
https://doi.org/10.1158/0008-5472.22419396
https://doi.org/10.1158/0008-5472.22419396
Autor:
Timothy A. Graubert, Lee Zou, Matthew J. Walter, Jack D. Sullivan, Pavankumar N.G. Reddy, Weiling Li, Wan Yee Leong, Hai Dang Nguyen
List of primers used for RNA splicing assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5c4fc150454cf4c24e7312c425312b
https://doi.org/10.1158/0008-5472.22419375.v1
https://doi.org/10.1158/0008-5472.22419375.v1