Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Timothy A. Blenkinsop"'
Autor:
Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig, Kapil Bharti
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for making progress in regenerati
Externí odkaz:
https://doaj.org/article/b5b13c2ea0074af788766f71aeeb249c
Autor:
Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y. C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, Sowmiya R, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation
Externí odkaz:
https://doaj.org/article/29658a3e9704480d80f0623a65432050
Autor:
Pradeep Gautam, Kiyofumi Hamashima, Ying Chen, Yingying Zeng, Bar Makovoz, Bhav Harshad Parikh, Hsin Yee Lee, Katherine Anne Lau, Xinyi Su, Raymond C. B. Wong, Woon-Khiong Chan, Hu Li, Timothy A. Blenkinsop, Yuin-Han Loh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
A comprehensive analysis of the ocular networks among various tissues is necessary to understand eye physiology in health and disease. Here the authors present a multi-species single-cell transcriptomic atlas consisting of cells of the cornea, iris,
Externí odkaz:
https://doaj.org/article/90aabc87256046d2ac0a0db19b2e943e
Autor:
Elke K. Markert, Holger Klein, Coralie Viollet, Werner Rust, Benjamin Strobel, Stefan G. Kauschke, Bar Makovoz, Heike Neubauer, Remko A. Bakker, Timothy A. Blenkinsop
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The therapeutic potential of pluripotent stem cells is great as they promise to usher in a new era of medicine where cells or organs may be prescribed to replace dysfunctional tissue. At the forefront are efforts in the eye to develop this technology
Externí odkaz:
https://doaj.org/article/3592200c6f66475a8e25a8522e509137
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101383- (2022)
Summary: Here, we describe a series of protocols detailing the steps for evaluating SARS-CoV-2 infection in models of the human eye. Included are protocols for whole eye organoid differentiation, SARS-CoV-2 infection, and processing organoids for sin
Externí odkaz:
https://doaj.org/article/0c99a4407e8a44c09493a54c2aa908c5
Autor:
Shawn Todd, Yuefang Ma, Liam M. Ashander, Binoy Appukuttan, Michael Z. Michael, Timothy A. Blenkinsop, Steven Yeh, Glenn A. Marsh, Justine R. Smith
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
Uveitis is a common manifestation of post-Ebola syndrome, associated with persistence of Ebola virus (EBOV; Zaire ebolavirus) inside the eye. The iris and retinal pigment epithelia are key components of the blood-ocular barriers, but have the capacit
Externí odkaz:
https://doaj.org/article/40757818c4964dac91252528def9d74b
Autor:
Richard J. Davis, Nazia M. Alam, Cuiping Zhao, Claudia Müller, Janmeet S. Saini, Timothy A. Blenkinsop, Francesca Mazzoni, Melissa Campbell, Susan M. Borden, Carol J. Charniga, Patty L. Lederman, Vanessa Aguilar, Michael Naimark, Michael Fiske, Nathan Boles, Sally Temple, Silvia C. Finnemann, Glen T. Prusky, Jeffrey H. Stern
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 42-49 (2017)
Age-related macular degeneration (AMD) is a common cause of central visual loss in the elderly. Retinal pigment epithelial (RPE) cell loss occurs early in the course of AMD and RPE cell transplantation holds promise to slow disease progression. We re
Externí odkaz:
https://doaj.org/article/2f04f00793cb4317b5d4af57e00a3b05
Autor:
Shervi Lie, Elise Rochet, Erik Segerdell, Yuefang Ma, Liam M. Ashander, Audra M. A. Shadforth, Timothy A. Blenkinsop, Michael Z. Michael, Binoy Appukuttan, Beth Wilmot, Justine R. Smith
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Ocular toxoplasmosis is the commonest clinical manifestation of infection with obligate intracellular parasite, Toxoplasma gondii. Active ocular toxoplasmosis is characterized by replication of T. gondii tachyzoites in the retina, with reactive infla
Externí odkaz:
https://doaj.org/article/068ff2293ab44a37a5dda935e061735b
Autor:
Boris V. Stanzel, Zengping Liu, Sudawadee Somboonthanakij, Warapat Wongsawad, Ralf Brinken, Nicole Eter, Barbara Corneo, Frank G. Holz, Sally Temple, Jeffrey H. Stern, Timothy A. Blenkinsop
Publikováno v:
Stem Cell Reports, Vol 2, Iss 1, Pp 64-77 (2014)
Transplantation of the retinal pigment epithelium (RPE) is being developed as a cell-replacement therapy for age-related macular degeneration. Human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC)-derived RPE are currently transla
Externí odkaz:
https://doaj.org/article/1200fe20b63c48859cf6b3cc85acf800
Autor:
Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y. C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, Sowmiya R, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su
Publikováno v:
Nature communications. 13(1)
One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-prolifera