Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Timothy A. Ayers"'
Autor:
Jian Shen, Jiping Yang, Winfried Heyse, Harald Schweitzer, Norbert Nagel, Doris Andert, Chengyue Zhu, Vincent Morrison, Gregory A. Nemeth, Teng-Man Chen, Zhicheng Zhao, Timothy A. Ayers, Yong-Mi Choi
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://doaj.org/article/e216df50786d432c972e05ee222dd331
Publikováno v:
Grief and Bereavement in Contemporary Society ISBN: 9781003199762
There is growing recognition that a wide gap exists between university-based experimental trials of intervention programs and successful delivery of these interventions in community settings. In the child treatment literature, Weisz and colleagues ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e430679937ec978647e6ecb19f692c3
https://doi.org/10.4324/9781003199762-13
https://doi.org/10.4324/9781003199762-13
Autor:
Jiping Yang, Jian Shen, Winfried Heyse, Doris Andert, Harald Schweitzer, Chengyue Zhu, Gregory A. Nemeth, Yong-Mi Choi, Zhicheng Zhao, Timothy A. Ayers, Vincent Morrison, Teng-Man Chen, Norbert Nagel
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286fd0572070c3d598a63939b6535cd2
Autor:
Timothy A. Ayers
Publikováno v:
Journal of Heterocyclic Chemistry. 50:1415-1418
C-H activation and isomerization using a Rh-catalyst provided quick access to dehydropiperidine derivatives that could be further oxidized to hydroxypiperidinone derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30262c5017b1772d39fa0a0c85b076d
https://doi.org/10.1002/jhet.1718
https://doi.org/10.1002/jhet.1718
Autor:
Vanasse Benoit J, Loc T. Tran, Juan Gamboa, Xuemin Chen, Timothy A. Ayers, Xiaodong Wu, Nakyen Choy, Rocco Disanto, Duane E. Rudisill, Duc P. Ngo, Ying Jiang, Geoffrey A. D'netto, Gardetto Anthony J, Sithamalli V. Chandramouli, David J. Lythgoe, Frederick Roberts, Narendra Kumar, Matthew R. Powers, Andrew W. Bridge, James H. Peers, Warren Copeland, Clive Pemberton
Publikováno v:
Organic Process Research & Development. 16:484-494
An enantioselective Overman 3,3-sigmatropic rearrangement on a quinuclidine skeleton was developed for the pilot-plant synthesis of a glycine transporter 1 inhibitor. The first stereocenter was produced by a Ru-catalyzed asymmetric transfer hydrogena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284ad18f5a7d149f6244c6ddedaa3d5a
https://doi.org/10.1021/op200378r
https://doi.org/10.1021/op200378r
Publikováno v:
Organic Process Research & Development. 16:141-147
An enantiospecific 1,2-amine migration process through an aziridinium intermediate involving ring-opening with potassium phthalimide derivatives to produce precursors to drug candidates was developed. The precursor amine derivatives were readily avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f866ea72b0d6f95e1c674f64f8efb75b
https://doi.org/10.1021/op200310y
https://doi.org/10.1021/op200310y
Autor:
Emil B. Lobkovsky, Sol M. Gruner, David B. Collum, Timothy A. Ayers, Anne J. McNeil, Sithamalli V. Chandramouli, Vanasse Benoit J, Gilman E. S. Toombes
Publikováno v:
Journal of the American Chemical Society. 126:16559-16568
Alkylation of beta-amino ester enolates proceeds with high diastereoselectivity. Single crystal, powder, and solution X-ray diffraction studies of the enolate show that the racemic enolate forms prismatic hexamers. 6Li NMR spectroscopic studies on pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2d47cc75b07b2d63029ceed3bb8e9e
https://doi.org/10.1021/ja045144i
https://doi.org/10.1021/ja045144i
Autor:
David W. Freund, Mark Webster, Timothy A. Ayers, Timothy J. N. Watson, David L. Wenstrup, Stephen W. Horgan, Nik Shah, James P. Carey
Publikováno v:
Organic Process Research & Development. 7:521-532
A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c1839c17be21d1f88b24d9482e980c3
https://doi.org/10.1021/op020225p
https://doi.org/10.1021/op020225p
Autor:
Albert L. Casalnuovo, Nobuyoshi Nomura, Timothy A. Ayers, T. V. RajanBabu, Malay Nandi, Haengsoon Park, Jian Jin
Publikováno v:
Current Organic Chemistry. 7:301-316
In this era of heightened environmental awareness and ever-increasing demand for higher efficiency from chemical processes, one of the major challenges facing organic synthesis is the utilization of abundantly available carbon sources as precursors f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71156ed9f2dd6959737bfcb95ea65667
https://doi.org/10.2174/1385272033372824
https://doi.org/10.2174/1385272033372824
Autor:
Roger E. Millsap, Timothy S. Ayers, Cady Berkel, Irwin N. Sandler, Erin Schoenfelder, Sharlene A. Wolchik
The study developed a multi-dimensional measure to assess participant responsiveness to a preventive intervention, and applied this measure to study how participant baseline characteristics predict responsiveness and how responsiveness predicts progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7151c5829e710e0eaa2a2f6c3bbaec8
https://europepmc.org/articles/PMC3655082/
https://europepmc.org/articles/PMC3655082/