Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Timothy A Thornton"'
Autor:
Ryan Schubert, Elyse Geoffroy, Isabelle Gregga, Ashley J Mulford, Francois Aguet, Kristin Ardlie, Robert Gerszten, Clary Clish, David Van Den Berg, Kent D Taylor, Peter Durda, W Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell Tracy, Matthew Conomos, Tom Blackwell, George Papanicolaou, Tuuli Lappalainen, Anna V Mikhaylova, Timothy A Thornton, Michael H Cho, Christopher R Gignoux, Leslie Lange, Ethan Lange, Stephen S Rich, Jerome I Rotter, NHLBI TOPMed Consortium, Ani Manichaikul, Hae Kyung Im, Heather E Wheeler
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0264341 (2022)
Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of the genetically regulated proteome for understanding complex trait mec
Externí odkaz:
https://doaj.org/article/2741c7e5394e4c0eba49bd272e4aab8d
Autor:
Bridget M Lin, Kelsey E Grinde, Jennifer A Brody, Charles E Breeze, Laura M Raffield, Josyf C Mychaleckyj, Timothy A Thornton, James A Perry, Leslie J Baier, Lisa de las Fuentes, Xiuqing Guo, Benjamin D Heavner, Robert L Hanson, Yi-Jen Hung, Huijun Qian, Chao A Hsiung, Shih-Jen Hwang, Margaret R Irvin, Deepti Jain, Tanika N Kelly, Sayuko Kobes, Leslie Lange, James P Lash, Yun Li, Xiaoming Liu, Xuenan Mi, Solomon K Musani, George J Papanicolaou, Afshin Parsa, Alex P Reiner, Shabnam Salimi, Wayne H-H Sheu, Alan R Shuldiner, Kent D Taylor, Albert V Smith, Jennifer A Smith, Adrienne Tin, Dhananjay Vaidya, Robert B Wallace, Kenichi Yamamoto, Saori Sakaue, Koichi Matsuda, Yoichiro Kamatani, Yukihide Momozawa, Lisa R Yanek, Betsi A Young, Wei Zhao, Yukinori Okada, Gonzalo Abecasis, Bruce M Psaty, Donna K Arnett, Eric Boerwinkle, Jianwen Cai, Ida Yii-Der Chen, Adolfo Correa, L Adrienne Cupples, Jiang He, Sharon LR Kardia, Charles Kooperberg, Rasika A Mathias, Braxton D Mitchell, Deborah A Nickerson, Steve T Turner, Vasan S Ramachandran, Jerome I Rotter, Daniel Levy, Holly J Kramer, Anna Köttgen, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Kidney Working Group, Stephen S Rich, Dan-Yu Lin, Sharon R Browning, Nora Franceschini
Publikováno v:
EBioMedicine, Vol 63, Iss , Pp 103157- (2021)
Background: Genetic factors that influence kidney traits have been understudied for low frequency and ancestry-specific variants. Methods: We combined whole genome sequencing (WGS) data from 23,732 participants from 10 NHLBI Trans-Omics for Precision
Externí odkaz:
https://doaj.org/article/c8ad41d9f4814d95a145fccc6f715b67
Autor:
Kevin L Keys, Angel C Y Mak, Marquitta J White, Walter L Eckalbar, Andrew W Dahl, Joel Mefford, Anna V Mikhaylova, María G Contreras, Jennifer R Elhawary, Celeste Eng, Donglei Hu, Scott Huntsman, Sam S Oh, Sandra Salazar, Michael A Lenoir, Jimmie C Ye, Timothy A Thornton, Noah Zaitlen, Esteban G Burchard, Christopher R Gignoux
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008927 (2020)
The genetic control of gene expression is a core component of human physiology. For the past several years, transcriptome-wide association studies have leveraged large datasets of linked genotype and RNA sequencing information to create a powerful ge
Externí odkaz:
https://doaj.org/article/22c150d8426343a09ce557fa67ba7215
Autor:
Colton Leavitt, Neil A Zakai, Paul Auer, Mary Cushman, Ethan M Lange, Emily B Levitan, Nels Olson, Timothy A Thornton, Russell P Tracy, James G Wilson, Leslie A Lange, Alex P Reiner, Laura M Raffield
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231013 (2020)
Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely une
Externí odkaz:
https://doaj.org/article/5e4f3bd994644621ba2daf027309147b
Autor:
Madeline H Kowalski, Huijun Qian, Ziyi Hou, Jonathan D Rosen, Amanda L Tapia, Yue Shan, Deepti Jain, Maria Argos, Donna K Arnett, Christy Avery, Kathleen C Barnes, Lewis C Becker, Stephanie A Bien, Joshua C Bis, John Blangero, Eric Boerwinkle, Donald W Bowden, Steve Buyske, Jianwen Cai, Michael H Cho, Seung Hoan Choi, Hélène Choquet, L Adrienne Cupples, Mary Cushman, Michelle Daya, Paul S de Vries, Patrick T Ellinor, Nauder Faraday, Myriam Fornage, Stacey Gabriel, Santhi K Ganesh, Misa Graff, Namrata Gupta, Jiang He, Susan R Heckbert, Bertha Hidalgo, Chani J Hodonsky, Marguerite R Irvin, Andrew D Johnson, Eric Jorgenson, Robert Kaplan, Sharon L R Kardia, Tanika N Kelly, Charles Kooperberg, Jessica A Lasky-Su, Ruth J F Loos, Steven A Lubitz, Rasika A Mathias, Caitlin P McHugh, Courtney Montgomery, Jee-Young Moon, Alanna C Morrison, Nicholette D Palmer, Nathan Pankratz, George J Papanicolaou, Juan M Peralta, Patricia A Peyser, Stephen S Rich, Jerome I Rotter, Edwin K Silverman, Jennifer A Smith, Nicholas L Smith, Kent D Taylor, Timothy A Thornton, Hemant K Tiwari, Russell P Tracy, Tao Wang, Scott T Weiss, Lu-Chen Weng, Kerri L Wiggins, James G Wilson, Lisa R Yanek, Sebastian Zöllner, Kari E North, Paul L Auer, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, Laura M Raffield, Alexander P Reiner, Yun Li
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008500 (2019)
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more com
Externí odkaz:
https://doaj.org/article/e2012563f33841c88441169fde0c6cd0
Autor:
Brian E Cade, Han Chen, Adrienne M Stilp, Tin Louie, Sonia Ancoli-Israel, Raanan Arens, Richard Barfield, Jennifer E Below, Jianwen Cai, Matthew P Conomos, Daniel S Evans, Alexis C Frazier-Wood, Sina A Gharib, Kevin J Gleason, Daniel J Gottlieb, David R Hillman, W Craig Johnson, David J Lederer, Jiwon Lee, Jose S Loredo, Hao Mei, Sutapa Mukherjee, Sanjay R Patel, Wendy S Post, Shaun M Purcell, Alberto R Ramos, Kathryn J Reid, Ken Rice, Neomi A Shah, Tamar Sofer, Kent D Taylor, Timothy A Thornton, Heming Wang, Kristine Yaffe, Phyllis C Zee, Craig L Hanis, Lyle J Palmer, Jerome I Rotter, Katie L Stone, Gregory J Tranah, James G Wilson, Shamil R Sunyaev, Cathy C Laurie, Xiaofeng Zhu, Richa Saxena, Xihong Lin, Susan Redline
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1007739 (2019)
Sleep disordered breathing (SDB)-related overnight hypoxemia is associated with cardiometabolic disease and other comorbidities. Understanding the genetic bases for variations in nocturnal hypoxemia may help understand mechanisms influencing oxygenat
Externí odkaz:
https://doaj.org/article/c8e538632b9b471aacf35acd2dd1bf66
Autor:
Brenton R Swenson, Tin Louie, Henry J Lin, Raúl Méndez-Giráldez, Jennifer E Below, Cathy C Laurie, Kathleen F Kerr, Heather Highland, Timothy A Thornton, Kelli K Ryckman, Charles Kooperberg, Elsayed Z Soliman, Amanda A Seyerle, Xiuqing Guo, Kent D Taylor, Jie Yao, Susan R Heckbert, Dawood Darbar, Lauren E Petty, Barbara McKnight, Susan Cheng, Natalie A Bello, Eric A Whitsel, Craig L Hanis, Mike A Nalls, Daniel S Evans, Jerome I Rotter, Tamar Sofer, Christy L Avery, Nona Sotoodehnia
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217796 (2019)
BackgroundThe electrocardiographically quantified QRS duration measures ventricular depolarization and conduction. QRS prolongation has been associated with poor heart failure prognosis and cardiovascular mortality, including sudden death. While prev
Externí odkaz:
https://doaj.org/article/51703293c27242d6ac467933a3abc165
Autor:
Laura M Raffield, Jacob C Ulirsch, Rakhi P Naik, Samuel Lessard, Robert E Handsaker, Deepti Jain, Hyun M Kang, Nathan Pankratz, Paul L Auer, Erik L Bao, Joshua D Smith, Leslie A Lange, Ethan M Lange, Yun Li, Timothy A Thornton, Bessie A Young, Goncalo R Abecasis, Cathy C Laurie, Deborah A Nickerson, Steven A McCarroll, Adolfo Correa, James G Wilson, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis, Diabetes, and Structural Variation TOPMed Working Groups, Guillaume Lettre, Vijay G Sankaran, Alex P Reiner
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007293 (2018)
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However, little information exists on the association and interactions for the common African ancest
Externí odkaz:
https://doaj.org/article/9ca17fd0506d404caeb1d4f46a790b11
Autor:
Chani J Hodonsky, Deepti Jain, Ursula M Schick, Jean V Morrison, Lisa Brown, Caitlin P McHugh, Claudia Schurmann, Diane D Chen, Yong Mei Liu, Paul L Auer, Cecilia A Laurie, Kent D Taylor, Brian L Browning, Yun Li, George Papanicolaou, Jerome I Rotter, Ryo Kurita, Yukio Nakamura, Sharon R Browning, Ruth J F Loos, Kari E North, Cathy C Laurie, Timothy A Thornton, Nathan Pankratz, Daniel E Bauer, Tamar Sofer, Alex P Reiner
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006760 (2017)
Prior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies have not included individuals with an Amerindian ancestral background, such as Hispanics/Latinos, nor e
Externí odkaz:
https://doaj.org/article/d79b27a0384a489caf7bdbe0fd8fe84d
Autor:
Tamar Sofer, Leslie J Baier, Sharon R Browning, Timothy A Thornton, Gregory A Talavera, Sylvia Wassertheil-Smoller, Martha L Daviglus, Robert Hanson, Sayuko Kobes, Richard S Cooper, Jianwen Cai, Daniel Levy, Alex P Reiner, Nora Franceschini
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188400 (2017)
Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the bl
Externí odkaz:
https://doaj.org/article/07a58fb01571401faddc87b88e9b5a55