Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Timothy A Hill"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59415 (2013)
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic
Externí odkaz:
https://doaj.org/article/79d79d2f77d44a0fb8774105cc86847a
Autor:
Frances Claire Manning, Lip Khoon Kho, Timothy Charles Hill, Tiara Nales Nyawai, Elisa Rumpang, Yit Arn Teh
Publikováno v:
Frontiers in Forests and Global Change, Vol 6 (2024)
Oil palm plantations growing on peat soil are associated with high soil CO2 emissions. Oil palm plantations are set up with regular spatial patterns consisting of different surface management microforms: bare soil harvest paths, frond piles, cover pl
Externí odkaz:
https://doaj.org/article/7cf8f740c2b34a69b783608d2f0aaf10
Autor:
Ian J. Bateman, Karen Anderson, Arthur Argles, Claire Belcher, Richard A. Betts, Amy Binner, Richard E. Brazier, Frankie H. T. Cho, Rebecca M. Collins, Brett H. Day, Carolina Duran‐Rojas, Sabrina Eisenbarth, Kate Gannon, Naomi Gatis, Ben Groom, Rosie Hails, Anna B. Harper, Amii Harwood, Astley Hastings, Matthew S. Heard, Timothy C. Hill, Alex Inman, Christopher F. Lee, David J. Luscombe, Angus R. MacKenzie, Mattia C. Mancini, James I. L. Morison, Aaron Morris, Chris P. Quine, Pat Snowdon, Charles R. Tyler, Elena I. Vanguelova, Matthew Wilkinson, Daniel Williamson, Georgios Xenakis
Publikováno v:
People and Nature, Vol 5, Iss 2, Pp 271-301 (2023)
Abstract We outline the principles of the natural capital approach to decision making and apply these to the contemporary challenge of very significantly expanding woodlands as contribution to attaining net zero emissions of greenhouse gases. Drawing
Externí odkaz:
https://doaj.org/article/28ea2ee43479439ea14ef3f2645a36aa
Autor:
Rachel F. Rollo, Giorgia Mori, Timothy A. Hill, Doris Hillemann, Stefan Niemann, Susanne Homolka, David P. Fairlie, Antje Blumenthal
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Shorter and more effective treatment regimens as well as new drugs are urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple antibiotics with diverse mechanisms of actio
Externí odkaz:
https://doaj.org/article/833f0bedf8da40d99d8b123434117953
Autor:
Kennedy Lewis, Fernanda de V. Barros, Marcio B. Cure, Christian A. Davies, Mariana N. Furtado, Timothy C. Hill, Marina Hirota, Demétrius L. Martins, Guilherme G. Mazzochini, Edward T. A. Mitchard, Cássia B. R. Munhoz, Rafael S. Oliveira, Alexandre B. Sampaio, Nicholas A. Saraiva, Isabel B. Schmidt, Lucy Rowland
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Native vegetation across the Brazilian Cerrado is highly heterogeneous and biodiverse and provides important ecosystem services, including carbon and water balance regulation, however, land-use changes have been extensive. Conservation and r
Externí odkaz:
https://doaj.org/article/b9395837b03f4cf390b56b1825a35d42
Publikováno v:
Journal of Innate Immunity, Pp 1-1 (2023)
Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a
Externí odkaz:
https://doaj.org/article/1af457e2956d4e20a155fd9703487f88
Autor:
Dominic Fawcett, Andrew M. Cunliffe, Stephen Sitch, Michael O’Sullivan, Karen Anderson, Richard E. Brazier, Timothy C. Hill, Peter Anthoni, Almut Arneth, Vivek K. Arora, Peter R. Briggs, Daniel S. Goll, Atul K. Jain, Xiaojun Li, Danica Lombardozzi, Julia E. M. S. Nabel, Benjamin Poulter, Roland Séférian, Hanqin Tian, Nicolas Viovy, Jean-Pierre Wigneron, Andy Wiltshire, Soenke Zaehle
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
Drylands cover ca. 40% of the land surface and are hypothesised to play a major role in the global carbon cycle, controlling both long-term trends and interannual variation. These insights originate from land surface models (LSMs) that have not been
Externí odkaz:
https://doaj.org/article/696d7b37db1047f292fd7f30c2c297a1
Autor:
Peiqi Wang, Timothy A. Hill, Justin Mitchell, Rebecca L. Fitzsimmons, Weijun Xu, Zhixuan Loh, Jacky Y. Suen, Junxian Lim, Abishek Iyer, David P. Fairlie
Publikováno v:
Journal of Medicinal Chemistry. 65:11759-11775
Glucagon-like peptide-1 (GLP-1) lowers blood glucose by inducing insulin but also has other poorly understood properties. Here, we show that hydroxy amino acids (Thr11, Ser14, Ser17, Ser18) in GLP-1(7-36) act in concert to direct cell signaling. Muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b49f968f4f8fdce8a47b3bc1f3761e
https://doi.org/10.1021/acs.jmedchem.2c00653
https://doi.org/10.1021/acs.jmedchem.2c00653
Autor:
Peter W. Gunning, Timothy P. Cripe, Wolfgang Weninger, Ian Dixon, Vivienne E. Reeve, David Winlaw, Edna C. Hardeman, Stephen J. Palmer, Galina Schevzov, Adam McCluskey, Timothy A. Hill, Thomas Fath, Munif Allanson, Tanya L. Butler, Vanessa B. Sequeira, Paula R.B.B. Nascimento, Jun Zeng, Herbert Treutlein, Gregg Kottyan, Melissa Desouza, Teresa Bonello, Nikolas K. Haass, Justine R. Stehn
The actin cytoskeleton is a potentially vulnerable property of cancer cells, yet chemotherapeutic targeting attempts have been hampered by unacceptable toxicity. In this study, we have shown that it is possible to disrupt specific actin filament popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26aeb0a4df2ed1d4a6bcc28ad80f73a4
https://doi.org/10.1158/0008-5472.c.6505788
https://doi.org/10.1158/0008-5472.c.6505788
Autor:
Peter W. Gunning, Timothy P. Cripe, Wolfgang Weninger, Ian Dixon, Vivienne E. Reeve, David Winlaw, Edna C. Hardeman, Stephen J. Palmer, Galina Schevzov, Adam McCluskey, Timothy A. Hill, Thomas Fath, Munif Allanson, Tanya L. Butler, Vanessa B. Sequeira, Paula R.B.B. Nascimento, Jun Zeng, Herbert Treutlein, Gregg Kottyan, Melissa Desouza, Teresa Bonello, Nikolas K. Haass, Justine R. Stehn
PDF file - 1137K, Supplementary Figure 1: Tropomyosin siRNA knockdown is isoform specific and does not result in any compensation. Supplementary Figure 2: TR100 nullifies the impact of Tm5NM1 on actin filament depolymerization kinetics. Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a67470c9b0ede032a904e3d83d8998e
https://doi.org/10.1158/0008-5472.22401237
https://doi.org/10.1158/0008-5472.22401237