Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Timothy A Hacker"'
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199213 (2018)
Although prenatal alcohol exposure (PAE) reduces offspring growth, it may increase obesity risk at adolescence. Animal models of PAE display glucose intolerance and increased adiposity, suggesting that PAE causes metabolic reprogramming. We tested th
Externí odkaz:
https://doaj.org/article/cb278a85bfe44a5d9e5200b7727be18b
Autor:
Shinichi Someya, Gregory C Kujoth, Mi-Jung Kim, Timothy A Hacker, Marc Vermulst, Richard Weindruch, Tomas A Prolla
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171159 (2017)
Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (PolgD257A/D257A), harboring a proofreading-deficient version of the mtDNA polymerase gamma
Externí odkaz:
https://doaj.org/article/d0cf2fabc2cc46abae69badfebb375fe
Autor:
Ching Ying Huang, Martin W. Nicholson, Jyun Yuan Wang, Chien Yu Ting, Ming Heng Tsai, Yu Che Cheng, Chun Lin Liu, Darien Z.H. Chan, Yi Chan Lee, Ching Chuan Hsu, Yu Hung Hsu, Chiou Fong Yang, Cindy M.C. Chang, Shu Chian Ruan, Po Ju Lin, Jen Hao Lin, Li Lun Chen, Marvin L. Hsieh, Yuan Yuan Cheng, Wan Tseng Hsu, Yi Ling Lin, Chien Hsiun Chen, Yu Hsiang Hsu, Ying Ta Wu, Timothy A. Hacker, Joseph C. Wu, Timothy J. Kamp, Patrick C.H. Hsieh
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114748- (2024)
Externí odkaz:
https://doaj.org/article/9ae5935c5e08433db79b9871e1e395fe
Autor:
Valerie Joers, Kailie Seneczko, Nichole C Goecks, Timothy J Kamp, Timothy A Hacker, Kevin G Brunner, Jonathan W Engle, Todd E Barnhart, R Jerome Nickles, James E Holden, Marina E Emborg
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35371 (2012)
Parkinson's disease presents nonmotor complications such as autonomic dysfunction that do not respond to traditional anti-parkinsonian therapies. The lack of established preclinical monkey models of Parkinson's disease with cardiac dysfunction hamper
Externí odkaz:
https://doaj.org/article/227a297f5ff0455782ea44e8cdfb6481
Autor:
Matthew J Brody, Timothy A Hacker, Jitandrakumar R Patel, Li Feng, Junichi Sadoshima, Sergei G Tevosian, Ravi C Balijepalli, Richard L Moss, Youngsook Lee
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51621 (2012)
Leucine-rich repeat containing 10 (LRRC10) is a cardiac-specific protein exclusively expressed in embryonic and adult cardiomyocytes. However, the role of LRRC10 in mammalian cardiac physiology remains unknown. To determine if LRRC10 is critical for
Externí odkaz:
https://doaj.org/article/961382c0f5c64e899dc275c3743f8e1c
Autor:
Jamie L Barger, Tsuyoshi Kayo, James M Vann, Edward B Arias, Jelai Wang, Timothy A Hacker, Ying Wang, Daniel Raederstorff, Jason D Morrow, Christiaan Leeuwenburgh, David B Allison, Kurt W Saupe, Gregory D Cartee, Richard Weindruch, Tomas A Prolla
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2264 (2008)
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose
Externí odkaz:
https://doaj.org/article/e25f222114b3420ba995866183387c34
Autor:
Hung-Chih Chen, Yen-Wen Liu, Kuan-Cheng Chang, Yen-Wen Wu, Yi-Ming Chen, Yu-Kai Chao, Min-Yi You, David J. Lundy, Chen-Ju Lin, Marvin L. Hsieh, Yu-Che Cheng, Ray P. Prajnamitra, Po-Ju Lin, Shu-Chian Ruan, David Hsin-Kuang Chen, Edward S. C. Shih, Ke-Wei Chen, Shih-Sheng Chang, Cindy M. C. Chang, Riley Puntney, Amy Wu Moy, Yuan-Yuan Cheng, Hsin-Yuan Chien, Jia-Jung Lee, Deng-Chyang Wu, Ming-Jing Hwang, Jennifer Coonen, Timothy A. Hacker, C-L. Eric Yen, Federico E. Rey, Timothy J. Kamp, Patrick C. H. Hsieh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The gut microbiome and its metabolites are increasingly implicated in several cardiovascular diseases, but their role in human myocardial infarction (MI) injury responses have yet to be established. To address this, we examined stool samples
Externí odkaz:
https://doaj.org/article/6361bc3495944b3fb58bc006af3e56af
Autor:
Jun Li, Corey Carlos, Hao Zhou, Jiajie Sui, Yikai Wang, Zulmari Silva-Pedraza, Fan Yang, Yutao Dong, Ziyi Zhang, Timothy A. Hacker, Bo Liu, Yanchao Mao, Xudong Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Stretchability is an essential property for wearable devices to match varying strains when interfacing with soft tissues or organs. While piezoelectricity has broad application potentials as tactile sensors, artificial skins, or nanogenerato
Externí odkaz:
https://doaj.org/article/1c9122a11a0a431d86c6673bf6f85ea9
Autor:
Yanghai Zhang, Zachery R. Gregorich, Yujuan Wang, Camila Urbano Braz, Jibin Zhang, Yang Liu, Peiheng Liu, Jiaxi Shen, Nanyumuzi Aori, Timothy A. Hacker, Henk Granzier, Wei Guo
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Human patients carrying genetic mutations in RNA binding motif 20 (RBM20) develop a clinically aggressive dilated cardiomyopathy (DCM). Genetic mutation knockin (KI) animal models imply that altered function of the arginine-serine-rich (RS) domain is
Externí odkaz:
https://doaj.org/article/64c14405f01b43cf841138c800152afd
Autor:
Rashid Al Mukaddim, Ashley M. Weichmann, Rachel Taylor, Timothy A. Hacker, Thomas Pier, Joseph Hardin, Melissa Graham, Carol C. Mitchell, Tomy Varghese
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract An adaptive Bayesian regularized cardiac strain imaging (ABR-CSI) algorithm for in vivo murine myocardial function assessment is presented. We report on 31 BALB/CJ mice (n = 17 females, n = 14 males), randomly stratified into three surgical
Externí odkaz:
https://doaj.org/article/8ea48587bea14d1f981c9ec3af5fe954