Zobrazeno 1 - 10
of 805
pro vyhledávání: '"Timothy A Chan"'
Autor:
Vladimir Makarov, Paul Nghiem, Jaehyuk Choi, Timothy A Chan, Kimberly S Smythe, Jean S Campbell, Robert H Pierce, Raphael Gottardo, Candice Church, David M Koelle, Thomas Pulliam, Natalie Longino, Song Y Park, Nadeem Riaz, Lichen Jing, Robert Amezquita
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Merkel cell carcinoma (MCC) often responds to PD-1 pathway blockade, regardless of tumor-viral status (~80% of cases driven by the Merkel cell polyomavirus (MCPyV)). Prior studies have characterized tumor-specific T cell responses to MCPyV
Externí odkaz:
https://doaj.org/article/5ad5aa1d8a2c41f09cc92ec9ecc890fa
Autor:
Udo S Gaipl, Dmitriy Zamarin, Felipe Prosper, Francesco M Marincola, Alessandra Cesano, Howard L Kaufman, Laurence Zitvogel, Tim Illidge, Taha Merghoub, Sandra Demaria, Abhishek D Garg, Patrizia Agostinis, James W Hodge, George Coukos, Akseli Hemminki, Öystein Rekdal, Jian Han, John Stagg, Sarah Warren, Lorenzo Galluzzi, Dobrin Draganov, Silvia C Formenti, Mark J Smyth, Radek Špíšek, Michael T Lotze, Takahiro Yamazaki, Guido Kroemer, Daolin Tang, Eric Deutsch, Jitka Fucikova, Sofia R Gameiro, Ilio Vitale, Sandy Adjemian, Aitziber Buqué Martinez, Timothy A Chan, Richard L Edelson, Lucia Gabriele, Encouse Golden, Kevin J Harrington, Dewan Md Sakib Hossain, Michael Karin, Oliver Kepp, Juan Jose Lasarte, Sherene Loi, Gwenola Manic, Alan A Melcher, Karen L Mossman, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Bryan E Strauss, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenviro
Externí odkaz:
https://doaj.org/article/a9d90895f1e544d9989ad2cde51f79c0
Autor:
Christina Seo, MASc, Sameer Kushwaha, MD, Paul Angaran, MD, Peter Gozdyra, MA, Katherine S. Allan, PhD, Husam Abdel-Qadir, MD, PhD, Paul Dorian, MD, MSc, Timothy C.Y. Chan, PhD
Publikováno v:
CJC Open, Vol 6, Iss 11, Pp 1355-1362 (2024)
Background: Disparities in atrial fibrillation ablation rates have been studied previously, with a focus on either patient characteristics or systems factors, rather than geographic factors. The impact of electrophysiology (EP) centre practice patter
Externí odkaz:
https://doaj.org/article/253379092a644b7eb320d245a99d1fbd
Autor:
Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner, Hiromu Suzuki, Joo-Mi Yi, Timothy A Chan, Leander Van Neste, Wim Van Criekinge, Sandra van den Bosch, Manon van Engeland, Angela H Ting, Kamwing Jair, Wayne Yu, Minoru Toyota, Kohzoh Imai, Nita Ahuja, James G Herman, Stephen B Baylin
Publikováno v:
PLoS Genetics, Vol 3, Iss 9, Pp 1709-1723 (2007)
We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a pan
Externí odkaz:
https://doaj.org/article/255e50ac950f447a90f132b7d3c8660a
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135750 (2015)
Protein tyrosine phosphatase receptor type D (PTPRD) is a putative tumor suppressor in several cancers including head and neck squamous cell carcinoma (HNSCC). STAT3 is a frequently hyperactivated oncogene in HNSCC. As STAT3 is a direct substrate of
Externí odkaz:
https://doaj.org/article/a4374a0fd41c4de0aff149eef6a1db87
Autor:
Marsha Reyngold, Sevin Turcan, Dilip Giri, Kasthuri Kannan, Logan A Walsh, Agnes Viale, Marija Drobnjak, Linda T Vahdat, William Lee, Timothy A Chan
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103896 (2014)
The development of breast cancer metastasis is accompanied by dynamic transcriptome changes and dramatic alterations in nuclear and chromatin structure. The basis of these changes is incompletely understood. The DNA methylome of primary breast cancer
Externí odkaz:
https://doaj.org/article/0360697940084ab9b7eafa2c3f45addf
Autor:
Timothy A Chan, Sabine Glockner, Joo Mi Yi, Wei Chen, Leander Van Neste, Leslie Cope, James G Herman, Victor Velculescu, Kornel E Schuebel, Nita Ahuja, Stephen B Baylin
Publikováno v:
PLoS Medicine, Vol 5, Iss 5, p e114 (2008)
The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressor
Externí odkaz:
https://doaj.org/article/2719a47e3b454596ba7ff3156efbf729
Autor:
Cristina Valero, Mahdi Golkaram, Joris L. Vos, Bin Xu, Conall Fitzgerald, Mark Lee, Shannon Kaplan, Catherine Y. Han, Xin Pei, Reith Sarkar, Lillian A. Boe, Abhinav Pandey, Elizabeth S. Koh, Charlotte L. Zuur, David B. Solit, Traci Pawlowski, Li Liu, Alan L. Ho, Diego Chowell, Nadeem Riaz, Timothy A. Chan, Luc G.T. Morris
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
BACKGROUND Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) is generally an incurable disease, with patients experiencing median survival of under 10 months and significant morbidity. While immune checkpoint blockade (I
Externí odkaz:
https://doaj.org/article/a3ed24c58f7546a1a3e8b395d5a3c618
Autor:
Sven Liebig, Martin Neumann, Patricia Silva, Jutta Ortiz-Tanchez, Veronika Schulze, Konstandina Isaakidis, Cornelia Schlee, Michael P. Schroeder, Thomas Beder, Luc G. T. Morris, Timothy A. Chan, Lorenz Bastian, Thomas Burmeister, Stefan Schwartz, Nicola Gökbuget, Liliana H. Mochmann, Claudia D. Baldus
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract FAT atypical cadherin 1 (FAT1), a transmembrane protein, is frequently mutated in various cancer types and has been described as context-dependent tumor suppressor or oncogene. The FAT1 gene is mutated in 12–16% of T-cell acute leukemia (T
Externí odkaz:
https://doaj.org/article/73aaef34737c42fdadc2a0d1ed2b4094
Autor:
Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Wesley Wang, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Prajwal Rajappa, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment respon
Externí odkaz:
https://doaj.org/article/235cfdd3465841ec8a0ca9c96d6c14cb