Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Timothy A Blenkinsop"'
Publikováno v:
eLife, Vol 8 (2019)
The rules governing cerebellar output are not fully understood, but must involve Purkinje cell (PC) activity, as PCs are the major input to deep cerebellar nuclear (DCN) cells (which form the majority of cerebellar output). Here, the influence of PC
Externí odkaz:
https://doaj.org/article/9a1234556e434a8194f79fac5425d43a
Modulation of Purkinje cell complex spike waveform by synchrony levels in the olivocerebellar system
Autor:
Eric J Lang, Tianyu eTang, Colleen Y Suh, Jianqiang eXiao, Yuriy eKotsurovskyy, Timothy A Blenkinsop, Sarah P Marshall, Izumi eSugihara
Publikováno v:
Frontiers in Systems Neuroscience, Vol 8 (2014)
Purkinje cells (PCs) generate complex spikes (CSs) when activated by the olivocerebellar system. Unlike most spikes, the CS waveform is highly variable, with the number, amplitude, and timing of the spikelets that comprise it varying with each occurr
Externí odkaz:
https://doaj.org/article/b176cc20102643f3ac65a5cdf3b86911
Autor:
Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig, Kapil Bharti
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for making progress in regenerati
Externí odkaz:
https://doaj.org/article/b5b13c2ea0074af788766f71aeeb249c
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101383- (2022)
Summary: Here, we describe a series of protocols detailing the steps for evaluating SARS-CoV-2 infection in models of the human eye. Included are protocols for whole eye organoid differentiation, SARS-CoV-2 infection, and processing organoids for sin
Externí odkaz:
https://doaj.org/article/0c99a4407e8a44c09493a54c2aa908c5
Autor:
Elke K, Markert, Holger, Klein, Coralie, Viollet, Werner, Rust, Benjamin, Strobel, Stefan G, Kauschke, Bar, Makovoz, Heike, Neubauer, Remko A, Bakker, Timothy A, Blenkinsop
Publikováno v:
Frontiers in Cell and Developmental Biology. 10
The therapeutic potential of pluripotent stem cells is great as they promise to usher in a new era of medicine where cells or organs may be prescribed to replace dysfunctional tissue. At the forefront are efforts in the eye to develop this technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c930e44d7fe0140e16e106023dd7f7f2
https://doi.org/10.3389/fcell.2022.910040
https://doi.org/10.3389/fcell.2022.910040
Autor:
Shawn Todd, Yuefang Ma, Liam M. Ashander, Binoy Appukuttan, Michael Z. Michael, Timothy A. Blenkinsop, Steven Yeh, Glenn A. Marsh, Justine R. Smith
Publikováno v:
Frontiers in Virology. 2
Uveitis is a common manifestation of post-Ebola syndrome, associated with persistence of Ebola virus (EBOV; Zaire ebolavirus) inside the eye. The iris and retinal pigment epithelia are key components of the blood-ocular barriers, but have the capacit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb94fcdcec48cfb9d26ea1b64eaa65b
https://doi.org/10.3389/fviro.2022.892394
https://doi.org/10.3389/fviro.2022.892394
Autor:
Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y. C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, Sowmiya R, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su
Publikováno v:
Nature communications. 13(1)
One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8684216692dc5c09b19144c1c241c8f5
https://pubmed.ncbi.nlm.nih.gov/35589753
https://pubmed.ncbi.nlm.nih.gov/35589753
Autor:
Bar Makovoz, Pradeep Gautam, Katherine Anne Lau, Raymond C.B. Wong, Hu Li, Xinyi Su, Yuin-Han Loh, Hsin Yee Lee, Timothy A. Blenkinsop, Ying Chen, Woon-Khiong Chan, Kiyofumi Hamashima, Bhav Harshad Parikh, Yingying Zeng
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The retina is a widely profiled tissue in multiple species by single-cell RNA sequencing studies. However, integrative research of the retina across species is lacking. Here, we construct the first single-cell atlas of the human and porcine ocular co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fa9f95cb4f031daa4b94f5089e3126
https://doi.org/10.1038/s41467-021-25968-8
https://doi.org/10.1038/s41467-021-25968-8
Autor:
Skyler Uhl, Rasmus Møller, Benjamin R. tenOever, Anne Zebitz Eriksen, Timothy A. Blenkinsop, Bar Makovoz
Publikováno v:
Eriksen, A Z, Møller, R, Makovoz, B, Uhl, S A, tenOever, B R & Blenkinsop, T A 2021, ' SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium ', Cell Stem Cell, vol. 28, no. 7, pp. 1205-1220 . https://doi.org/10.1016/j.stem.2021.04.028
Cell Stem Cell
Cell Stem Cell
The SARS-CoV-2 pandemic has caused unparalleled disruption of global behavior and significant loss of life. To minimize SARS-CoV-2 spread, understanding the mechanisms of infection from all possible routes of entry is essential. While aerosol transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118ed9d41846df20649d90cd011e5af5
https://orbit.dtu.dk/en/publications/f13e0d1f-debd-47b1-a87f-ad9b17f87e55
https://orbit.dtu.dk/en/publications/f13e0d1f-debd-47b1-a87f-ad9b17f87e55
Autor:
Queenie Shu Woon Tan, Gavin Tan, Boris V. Stanzel, Veluchamy A Barathi, Daniel Soo Lin Wong, Zengping Liu, Kok Haur Ong, Graham E. Holder, Walter Hunziker, Weimiao Yu, Timothy A. Blenkinsop, Gopal Lingam, Xinyi Su, Ivan Seah, Bhav Harshad Parikh
Publikováno v:
Stem Cell Reports
Summary Recent trials of retinal pigment epithelium (RPE) transplantation for the treatment of disorders such as age-related macular degeneration have been promising. However, limitations of existing strategies include the uncertain survival of RPE c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035c773e228b0a4b10f0d5ecda3655be
https://pubmed.ncbi.nlm.nih.gov/33450191
https://pubmed.ncbi.nlm.nih.gov/33450191