Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Timothy A, Troppoli"'
Autor:
Timothy A. Troppoli, Panos Zanos, Polymnia Georgiou, Todd D. Gould, Uwe Rudolph, Scott M. Thompson
Publikováno v:
Biological psychiatry. 92(3)
Abnormal reward processing, typically anhedonia, is a hallmark of human depression and is accompanied by altered functional connectivity in reward circuits. Negative allosteric modulators of GABAAnhedonia was induced by chronic stress in male mice an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8fde3ec1dac1fc5d8075949b450c29
https://pubmed.ncbi.nlm.nih.gov/35835504
https://pubmed.ncbi.nlm.nih.gov/35835504
Autor:
Jacqueline Lovett, Xin Liu, Jaclyn N. Highland, Panos Zanos, Brent W. Stewart, Scott M. Thompson, Polymnia Georgiou, Craig J. Thomas, Patrick J. Morris, Timothy A. Troppoli, Todd D. Gould, Ruin Moaddel
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: (R)‐Ketamine (arketamine) may have utility as a rapidly acting antidepressant. While (R)‐ketamine has lower potency than (R,S)‐ketamine to inhibit NMDA receptors in vitro, the extent to which (R)‐ketamine shares the NM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f217b7dac4246af778c03191675041
https://doi.org/10.1111/bph.14683
https://doi.org/10.1111/bph.14683
Autor:
Peixiong Yuan, Jacqueline Lovett, Ruin Moaddel, Timothy A. Troppoli, Craig J. Thomas, Carleigh Jenne, Eric W. Lumsden, Panos Zanos, Fu-Hua Wang, Patrick J. Morris, Edson X. Albuquerque, Staffan Schmidt, Scott J. Myers, Stephen F. Traynelis, Jan Kehr, Scott M. Thompson, Sukhan Kim, Yasco Aracava, Edna F. R. Pereira, Carlos A. Zarate, Todd D. Gould
Publikováno v:
Proceedings of the National Academy of Sciences. 116:5160-5169
Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine’s antidepressant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793cdb62a68bc31140f1a2e2443ce37f
https://doi.org/10.1073/pnas.1816071116
https://doi.org/10.1073/pnas.1816071116
Autor:
Natalie Hesselgrave, Timothy A. Troppoli, Scott M. Thompson, Andreas B. Wulff, Anthony B. Cole
Publikováno v:
Proc Natl Acad Sci U S A
Depression is a widespread and devastating mental illness and the search for rapid-acting antidepressants remains critical. There is now exciting evidence that the psychedelic compound psilocybin produces not only powerful alterations of consciousnes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abceaf3e78dbf51275da10d086a6e56
https://pubmed.ncbi.nlm.nih.gov/33850049
https://pubmed.ncbi.nlm.nih.gov/33850049
Autor:
Eric W, Lumsden, Timothy A, Troppoli, Scott J, Myers, Panos, Zanos, Yasco, Aracava, Jan, Kehr, Jacqueline, Lovett, Sukhan, Kim, Fu-Hua, Wang, Staffan, Schmidt, Carleigh E, Jenne, Peixiong, Yuan, Patrick J, Morris, Craig J, Thomas, Carlos A, Zarate, Ruin, Moaddel, Stephen F, Traynelis, Edna F R, Pereira, Scott M, Thompson, Edson X, Albuquerque, Todd D, Gould
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(11)
Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine’s antidepressant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fea4226be62928bc830a4f9eba57b32
https://pubmed.ncbi.nlm.nih.gov/30796190
https://pubmed.ncbi.nlm.nih.gov/30796190