Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Timothy Norris"'
Autor:
Michael Rowe, Ayesha Hidayat, Timothy Norris, Adam Pollard, John McGrane, Alastair Thomson, Stuart Walter, Deborah Victor
Publikováno v:
Journal of Clinical Urology. 15:257-263
Objective: Enzalutamide is effective in treating metastatic castrate-resistant prostate cancer (mCRPC) but can have side effects that require treatment breaks (TB). We conducted a retrospective analysis of outcomes of patients who had extended TB due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2433bbff1f42e2ff73c641bed9b7d44
https://doi.org/10.1177/2051415821993760
https://doi.org/10.1177/2051415821993760
Autor:
John McGrane, Michael Rowe, Stuart Walter, Ayesha Hidayat, Hannah Donkers, Andrew Browne, Timothy Norris, Adam Pollard, Deborah Victor
Publikováno v:
Clinical Oncology and Research. :1-6
Background: We investigated our institution’s mCRPC enzalutamide or abiraterone patients examining PSA responses and impact of sequencing of these drugs. Methods: All enzalutamide / abiraterone mCRPC patients (2011-2018) were included. Rates of PSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79d0c2f97458d69714ed5df8c71f51e3
https://doi.org/10.31487/j.cor.2020.07.11
https://doi.org/10.31487/j.cor.2020.07.11
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 44(4)
Pembrolizumab is an anti-programmed cell death protein 1 immune checkpoint inhibitor with a dosing schedule of 200 mg 3 weekly (q3w). Dose of 400 mg 6 weekly (q6w) was approved based on simulation of dose/exposure relationships and predicted no diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b212c16c27220b1a1da21d83acff2256
https://pubmed.ncbi.nlm.nih.gov/33492031
https://pubmed.ncbi.nlm.nih.gov/33492031
Autor:
Deborah Victor, Ayesha Hidayat, S Walter, Timothy Norris, Adam Pollard, John McGrane, Michael Rowe
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 33(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ecaf95c64750c2f298377afb3381a0
https://pubmed.ncbi.nlm.nih.gov/32739115
https://pubmed.ncbi.nlm.nih.gov/32739115
Autor:
Stuart Walter, Deborah Victor, Adam Pollard, Alastair Thomson, Michael Rowe, Timothy Norris, Ayesha Hidayat, John McGrane
Publikováno v:
Journal of Clinical Oncology. 38:81-81
81 Background: Intermittent hormone manipulation in castrate-sensitive prostate cancer can improve quality of life whilst maintaining comparable disease outcomes with continuous scheduling. Enzalutamide is effective in metastatic castrate-resistant p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d86debdc4442a0becd982bb0bf46d4
https://doi.org/10.1200/jco.2020.38.6_suppl.81
https://doi.org/10.1200/jco.2020.38.6_suppl.81
Publikováno v:
Organic Process Research & Development. 13:354-357
A green chemistry methodology that uses a heavy-metal-free reduction in aqueous medium is described to produce 5-hydrazinoquinoline [1-(quinolin-5-yl)hydrazine] (6a) as the anhydrous dihydrochloride salt at large scale. The process is entirely aqueou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86e5841c9dfc20d8d375c4da73eef6d
https://doi.org/10.1021/op8002163
https://doi.org/10.1021/op8002163
Autor:
Marcus Ewing, Stephen E. Hubbs, John VanAlsten, Timothy Norris, Grace O. Jensen, Matthew L. Jorgensen, Weiling Cai, Jon Bordner
Publikováno v:
Organic Process Research & Development. 12:447-455
Many years ago anidulafungin 1 was identified as a potentially useful medicine for the treatment of fungal infections. Its chemical and physical properties as a relatively high molecular weight semisynthetic derived from echinocandin B proved to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a00c5a59a6ae225041509349c94f92ea
https://doi.org/10.1021/op800055h
https://doi.org/10.1021/op800055h
Publikováno v:
Organic Process Research & Development. 11:742-746
A process has been developed for the use of trimethylphosphite for the formation of the six-membered 3,6-dihydro-2H-[1,3]thiazine ring in the cephem architecture by an intramolecular Horner−Emmons−...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0190859a7d116cf0a76c0041f0b9181b
https://doi.org/10.1021/op700091d
https://doi.org/10.1021/op700091d
Publikováno v:
Organic Process Research & Development. 9:792-799
Prodrugs derived from the β-lactamase inhibitor 6-β-hydroxymethylsulbactam can be synthesized efficiently in a three-step process by making use of the highly stereoselective radical debromination utilizing tri-n-butylgermanium hydride. This reagent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df16dc73ecd755f647b398bc12d7d270
https://doi.org/10.1021/op050151s
https://doi.org/10.1021/op050151s
Autor:
Paul Ahlijanian, Jeroen Konings, Roberto Colon-Cruz, Dominique Monique Char Callant, Ben de Lange, Robert de Pater, Joel M. Hawkins, Lulin Wei, Jean Andrien, Jennifer Lea Rutherford, Kurt Stickley, Jos Hulshof, Peter Johannes Dominicus Maas, Timothy Norris, Roel Vollinga, Mark T. Barrila, David W. L. Sung, Michel Couturier, and Natalka Johnson, Ioulia V. Loubkina, Elena Daia, Brian M. Andresen, David H. Brown Ripin, Jos Versleijen
Publikováno v:
Organic Process Research & Development. 9:432-439
The optimization of the synthesis of 6β-hydroxymethylsulbactam is described. The primary challenge in this synthesis is the installation of the 6β-hydroxymethyl group with the proper stereochemistry. Engineering challenges associated with the addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ceefb76dc780bb9512786982ff4877
https://doi.org/10.1021/op050047a
https://doi.org/10.1021/op050047a