Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Timothy, Vortherms"'
Autor:
Marc J C, Scanio, Xenia B, Searle, Bo, Liu, John R, Koenig, Robert J, Altenbach, Gregory A, Gfesser, Andrew, Bogdan, Stephen, Greszler, Gang, Zhao, Ashvani, Singh, Yihong, Fan, Andrew M, Swensen, Timothy, Vortherms, Arlene, Manelli, Corina, Balut, Wenqing, Gao, Hong, Yong, Michael, Schrimpf, Chris, Tse, Philip, Kym, Xueqing, Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128843
Cystic fibrosis (CF) is an autosomal recessive disease resulting from mutations on both copies of the CFTR gene. Phenylalanine deletion at position 508 of the CFTR protein (F508del-CFTR) is the most frequent mutation in CF patients. Currently, the mo
Autor:
Xenia, Beebe, Daria, Darczak, Rodger F, Henry, Timothy, Vortherms, Richard, Janis, Marian, Namovic, Diana, Donnelly-Roberts, Karen L, Kage, Carol, Surowy, Ivan, Milicic, Wende, Niforatos, Andrew, Swensen, Kennan C, Marsh, Jill M, Wetter, Pamela, Franklin, Scott, Baker, Chengmin, Zhong, Gricelda, Simler, Erica, Gomez, Janel M, Boyce-Rustay, Chang Z, Zhu, Andrew O, Stewart, Michael F, Jarvis, Victoria E, Scott
Publikováno v:
Bioorganicmedicinal chemistry. 20(13)
A novel 4-aminocyclopentapyrrolidine series of N-type Ca(2+) channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectiv