Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

Autor: Enric Mocholi, Laura Russo, Keshav Gopal, Andrew G. Ramstead, Sophia M. Hochrein, Harmjan R. Vos, Geert Geeven, Adeolu O. Adegoke, Anna Hoekstra, Robert M. van Es, Jose Ramos Pittol, Sebastian Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin C. Anderson, Ryan M. O’Connell, Martin Vaeth, John Ussher, Boudewijn M.T. Burgering, Paul J. Coffer

Publikováno v: Cell Reports, Vol 42, Iss 6, Pp 112583- (2023)

Summary: Upon antigen-specific T cell receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that the generation of extramitochon

Externí odkaz: https://doaj.org/article/942f229d67194e4a9cd020cad65978f5

Efficacy and Safety of ABBV ‐3373, a Novel Anti–Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody–Drug Conjugate, in Adults with Moderate‐to‐Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double‐Blind , Active‐Controlled Proof‐of‐Concept Phase IIa Trial

Autor: Frank Buttgereit, Jacob Aelion, Bernadette Rojkovich, Anna Zubrzycka‐Sienkiewicz, Su Chen, Yang Yang, Dilek Arikan, Ronilda D'Cunha, Yinuo Pang, Hartmut Kupper, Timothy Radstake, Howard Amital

Publikováno v: Arthritis & Rheumatology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3a2cdaea2b5cb29e004036b46c9ab02
https://doi.org/10.1002/art.42415

Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies

Autor: Simon, Rothwell, Christopher I, Amos, Frederick W, Miller, Lisa G, Rider, Ingrid E, Lundberg, Peter K, Gregersen, Jiri, Vencovsky, Neil, McHugh, Vidya, Limaye, Albert, Selva-O'Callaghan, Michael G, Hanna, Pedro M, Machado, Lauren M, Pachman, Ann M, Reed, Øyvind, Molberg, Olivier, Benveniste, Pernille, Mathiesen, Timothy, Radstake, Andrea, Doria, Jan L, De Bleecker, Boel, De Paepe, Britta, Maurer, William E, Ollier, Leonid, Padyukov, Terrance P, O'Hanlon, Annette, Lee, Lucy R, Wedderburn, Hector, Chinoy, Janine A, Lamb, Richard J, Barohn

Publikováno v: Arthritisrheumatology (Hoboken, N.J.).

The idiopathic inflammatory myopathies (IIM) are heterogeneous diseases, thought to be initiated by immune activation in genetically predisposed individuals. In this study we imputed variants from the Immunochip array using a large reference panel to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97bebd235e0640c6934ff4349854d667
https://pubmed.ncbi.nlm.nih.gov/36580032

Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing

Autor: Sonia Abdelhak, Mehmet Ozturk, Bento Soares, Bernd Schmeck, Samir K. Brahmachari, Andrey Lisistsa, Leroy Hood, Philippe Sabatier, Carole Goble, Pierre Hainaut, Marion Koopmans, Alain Cozzone, Christian Bréchot, Nathan Price, Vitaly Volpert, David Supple, Elissa Epel, Peter Hunter, Bartha Maria Knoppers, Ursula Klingmüller, Timothy Radstake, Zhu Chen, Mathias Uhlén, Johann Pellet, Steve Webb, Anna Norrby-Teglund, Vincent Lotteau, Dominique Charron, Josep Roca, Jean-Marie Lehn, Maria Manuela Nogueira, François Gros, Françoise Argoul, Ferran Sanz, Martine Raes, Antoine Magnan, Peter J. M. Openshaw, Alain Fischer, Shlomo Sasson, Peter J. Sterk, Francis Lévi, Hiroaki Kitano, Susanna Palkonen, Ross Arena, Albert-László Barabási, Michel Goldman, Ian M. Adcock, Andrea Gelemanovic, Sai-Juan Chen, Christian Pristipino, Jacques Demotes, Jesper Tegnér, Anders Bjartell, Laurent P. Nicod, Yves Moreau, Walter Kolch, Laurent Nottale, Emiel F.M. Wouters, Ismail Serageldin, Ratko Djukanovic, Jean-François Deleuze, Anita Simonds, Alfredo Cesario, Ana Conesa, Stylianos E. Antonarakis, David Harrison, Hans Hoffmann, Sylvie van der Werf, Yves Jacob, Marta Cascante, Andres Metspalu, James N’Dow, Alvar Agusti, Herman Goossens, Bertrand Boutron, Rudi Balling, Francisco Nobrega, Jacques S. Beckmann, Menno de Jong, Margarida Amaral, Alberto Di Meglio, Niklas Blomberg, Fan Chung, Denis Noble, Doron Lancet, Charles Auffray, Giulio Superti-Furga, Takashi Gojobori, Christopher E. Brightling, Thomas Bourgeron, Ugur Dogrusoz, Damjana Rozman, Karine Clément, Yi-Ke Guo, Bongani M. Mayosi, Ozren Polasek, Martine Laville, Michael Sagner, Manlio Vinciguerra, Pablo Villoslada, Silvio Parodi

Publikováno v: PROGRESS IN PREVENTIVE MEDICINE
PROGRESS IN PREVENTIVE MEDICINE, 2017, ⟨10.1097/pp9.0000000000000006⟩
Progress in Preventive Medicine

ispartof: Progress in preventive medicine pages:1-2 status: published

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e64d735880d9408c1b7c17a3105940c
https://hal-pasteur.archives-ouvertes.fr/pasteur-04097586/file/Viva_Europa,_a_Land_of_Excellence_in_Research_and.1.pdf

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

Autor: Timothy Radstake

Publikováno v: Systemic Sclerosis-An Update on the Aberrant Immune System and Clinical Features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::683e3e223b95957025c9adf7943ca694
https://doi.org/10.5772/1326