Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Timothy, Palzkill"'
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Human noroviruses (HuNoV) are the leading cause of acute gastroenteritis worldwide. The humoral immune response plays an important role in clearing HuNoV infections and elucidating the antigenic landscape of HuNoV during an infection can she
Externí odkaz:
https://doaj.org/article/3ed69cec4f314db4ba9229e036cde478
Autor:
Allison Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B. V. Venkataram Prasad, Timothy Palzkill
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Structural analysis, antibiotic selection, and deep sequencing of CTX-M-14 mutants identify residues required for β-lactamase activity.
Externí odkaz:
https://doaj.org/article/ed30571a65cc486a86cee6c324e2db15
Autor:
Shuo Lu, Liya Hu, Hanfeng Lin, Allison Judge, Paola Rivera, Murugesan Palaniappan, Banumathi Sankaran, Jin Wang, B. V. Venkataram Prasad, Timothy Palzkill
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
β-lactamases are a source of antibiotic resistance. Here, the authors show that an active site loop in β-lactamase toggles between conformations that control antibiotic hydrolysis and inhibitor susceptibility, highlighting the role of active site c
Externí odkaz:
https://doaj.org/article/a5d4db58c65847129cf22ca9f00a6e31
Autor:
Zhizeng Sun, Timothy Palzkill
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Colistin (polymyxin E) and polymyxin B have been used as last-resort agents for treating infections caused by multidrug-resistant Gram-negative bacteria. However, their efficacy has been challenged by the emergence of the mobile colistin res
Externí odkaz:
https://doaj.org/article/e61867662dbd4c8aa81807caa3fdb7bb
Publikováno v:
Physical Chemistry Chemical Physics. 25:1349-1362
Resistance to carbapenem β-lactams presents major clinical and economical challenges for the treatment of pathogen infections. The fast hydrolysis of carbapenems by carbapenemase-producing bacterial strains enables the effective deactivation of carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78ca33596f09eec6da2f196b03994b3
https://doi.org/10.1039/d2cp03724f
https://doi.org/10.1039/d2cp03724f
Autor:
Shuo Lu, Victoria Soeung, Hoang A. T. Nguyen, S. Wesley Long, James M. Musser, Timothy Palzkill
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT Carbapenemases confer resistance to nearly all β-lactam antibiotics. The extensive spread of carbapenemase-producing multidrug-resistant bacteria contributes significantly to hospital-acquired infections. We have developed a novel protein-b
Externí odkaz:
https://doaj.org/article/4e6264aad7c54f7796a0912658b059b0
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The NDM-1 β-lactamase confers resistance to most β-lactam antibiotics. By functional analysis of residues required for hydrolysis, Sun et al. reveal stringent sequence constraints for carbapenems, suggesting that specific combinations of NDM-1 inhi
Externí odkaz:
https://doaj.org/article/8c2aae0dbe0a437bb3b03635d51701e9
Autor:
Margie N. Sutton, Zhen Lu, Yao-Cheng Li, Yong Zhou, Tao Huang, Albert S. Reger, Amy M. Hurwitz, Timothy Palzkill, Craig Logsdon, Xiaowen Liang, Joe W. Gray, Xiaolin Nan, John Hancock, Geoffrey M. Wahl, Robert C. Bast, Jr.
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3448-3459.e6 (2019)
Summary: Oncogenic RAS mutations drive cancers at many sites. Recent reports suggest that RAS dimerization, multimerization, and clustering correlate strongly with activation of RAS signaling. We have found that re-expression of DIRAS3, a RAS-related
Externí odkaz:
https://doaj.org/article/732fd049e7a34e8a9980c8c274457ff8
Autor:
Timothy Palzkill
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The most common mechanism of resistance to β-lactam antibiotics in Gram-negative bacteria is the production of β-lactamases that hydrolyze the drugs. Class A β-lactamases are serine active-site hydrolases that include the common TEM, CTX-M, and KP
Externí odkaz:
https://doaj.org/article/a0130862c0ad49f29a76b9e0c7e2018c