Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Timothy, Nicholas"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1615-1629 (2024)
Abstract PoissonERM is an R package used to conduct exposure–response (ER) analysis on binary outcomes for establishing the relationship between exposure and the occurrence of adverse events (AE). While Poisson regression could be implemented with
Externí odkaz:
https://doaj.org/article/b7d7614abb3949ff842731c85f0940ca
Autor:
Wei Gao, Jiang Liu, Blerta Shtylla, Karthik Venkatakrishnan, Donghua Yin, Mirat Shah, Timothy Nicholas, Yanguang Cao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 5, Pp 691-709 (2024)
Abstract Project Optimus is a US Food and Drug Administration Oncology Center of Excellence initiative aimed at reforming the dose selection and optimization paradigm in oncology drug development. This project seeks to bring together pharmaceutical c
Externí odkaz:
https://doaj.org/article/7b00914db39149309f99129a086a6b8b
Autor:
Cheng Chang, Camille Vong, Xiaoxing Wang, Anasuya Hazra, Annette Diehl, Timothy Nicholas, Arnab Mukherjee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 599-611 (2024)
Abstract These analyses characterized tofacitinib pharmacokinetics (PKs) in children and adolescents with juvenile idiopathic arthritis (JIA). Data were pooled from phase I (NCT01513902), phase III (NCT02592434), and open‐label, long‐term extensi
Externí odkaz:
https://doaj.org/article/64c3058604ec406bbe5527ac19e74f02
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 551-562 (2024)
Abstract The objective of this population pharmacokinetic (PK) analysis was to characterize the concentration–time profile of brepocitinib plasma concentration after single‐ and multiple‐oral administration in healthy volunteers (HVs) and patie
Externí odkaz:
https://doaj.org/article/efc00493230549498f4e04dcef08d177
Autor:
Phylinda L. S. Chan, Ravi Shankar P. Singh, Donna S. Cox, Haihong Shi, Bharat Damle, Timothy Nicholas
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1897-1910 (2023)
Abstract Protease inhibitor nirmatrelvir coadministered with ritonavir as a pharmacokinetic enhancer (PAXLOVID™; Pfizer Inc) became the first orally bioavailable antiviral agent granted Emergency Use Authorization in the United States in patients
Externí odkaz:
https://doaj.org/article/b476a8db40e94b18a86663a6931272c5
Autor:
Timothy Nicholas Fazio, Louise Healy, Tim Heise, Anita Inwood, Catherine Manolikos, Yusof Rahman, Hans-Juergen Woerle, Christian J. Hendriksz
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 37, Iss , Pp 101012- (2023)
The cornerstone treatment of hyperphenylalaninemia (HPA) and phenylketonuria (PKU) is a lifelong low-protein diet with phenylalanine (Phe) free L-amino acid supplements. However, the PKU diet has significant shortcomings, and there is a clinically un
Externí odkaz:
https://doaj.org/article/e8398e8fcb364d829a0c08abebf5f4a0
Autor:
Fazio, Timothy Nicholas, Healy, Louise, Heise, Tim, Inwood, Anita, Manolikos, Catherine, Rahman, Yusof, Woerle, Hans-Juergen, Hendriksz, Christian J.
Publikováno v:
In Molecular Genetics and Metabolism Reports December 2023 37
Autor:
Sana Loue, Timothy Nicholas
Publikováno v:
Medicina, Vol 59, Iss 11, p 2021 (2023)
Cultural competence training has been criticized for reinforcing existing stereotypes, ignoring intersectionality and inadvertently marginalizing some individuals and groups. In contrast, cultural humility offers the possibility of transformational l
Externí odkaz:
https://doaj.org/article/33d625390c3348dda23c9f4bc9c41e80
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 1, Pp 60-69 (2020)
PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε, key regulators of circadian rhythm. As a result of its mechanism of action, PF‐05251749 may also change the heart rate corrected QT (QTc) circadian rhythm, which may confound detection of
Externí odkaz:
https://doaj.org/article/cd7b2b302016406eb7aaa99959a23eec
Autor:
Klaus Romero, Daniela Conrado, Jackson Burton, Timothy Nicholas, Vikram Sinha, Sreeraj Macha, Malidi Ahamadi, Jesse Cedarbaum, John Seibyl, Kenneth Marek, Peter Basseches, Derek Hill, Ed Somer, Jill Gallagher, David T. Dexter, Arthur Roach, Diane Stephenson, for the Critical Path for Parkinson's (CPP) Consortium, the Parkinson's Progression Markers Initiative (PPMI)
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 3, Pp 240-246 (2019)
The Critical Path for Parkinson's (CPP) Imaging Biomarker and Modeling and Simulation working groups aimed to achieve qualification opinion by the European Medicines Agency (EMA) Committee for Medical Products for Human Use (CHMP) for the use of base
Externí odkaz:
https://doaj.org/article/947d1d44d90d4ee39519d4068df35b29