Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Timothy, McAfoos"'
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa5c2787960118aa25b0d20d0a771
https://doi.org/10.1158/0008-5472.c.6512119.v1
https://doi.org/10.1158/0008-5472.c.6512119.v1
Autor:
Nancy E. Kohl, Zhijun Kang, Connor A. Parker, Yuting Sun, Yongying Jiang, Simon S. Yu, Cross Jason, Ningping Feng, Faika Mseeh, Timothy McAfoos, Maria Emilia Di Francesco, Timothy P. Heffernan, Angela L. Harris, Brooke A. Meyers, Paul G. Leonard, Joseph R. Marszalek, Christopher C. Williams, Qi Wu, Jeffrey J. Kovacs, Pijus K. Mandal, Jason P Burke, Giulio Draetta, Barbara Czako, Philip Jones, Christopher Carroll
Publikováno v:
Journal of Medicinal Chemistry. 64:15141-15169
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in RTK-mediated resistance, making the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52237ec958405671436618b3a028bf48
https://doi.org/10.1021/acs.jmedchem.1c01132
https://doi.org/10.1021/acs.jmedchem.1c01132
Autor:
Norma Rogers, Stephan Krapp, Faika Mseeh, Richard T. Lewis, Keith Mikule, Michelle Han, Jay Theroff, Yongying Jiang, Keith M. Wilcoxen, Cross Jason, Dana Pfaffinger, Michael J. Soth, Paul G. Leonard, Philip Jones, Pijus K. Mandal, Angela L. Harris, Martin R. Tremblay, Simon S. Yu, Jason P Burke, Connor A. Parker, Barbara Czako, Alessia Petrocchi, Naphtali J. Reyna, Joseph R. Marszalek, Matthew M. Hamilton, Timothy McAfoos, Brett W. Virgin-Downey, Graham Trevitt, Alfred Lammens, Alan Xu
Publikováno v:
Journal of Medicinal Chemistry. 64:11302-11329
Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology. We developed a class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec33cf6551a670d4d40eaab2894a6f60
https://doi.org/10.1021/acs.jmedchem.1c00679
https://doi.org/10.1021/acs.jmedchem.1c00679
Autor:
Barbara, Czako, Yuting, Sun, Timothy, McAfoos, Jason B, Cross, Paul G, Leonard, Jason P, Burke, Christopher L, Carroll, Ningping, Feng, Angela L, Harris, Yongying, Jiang, Zhijun, Kang, Jeffrey J, Kovacs, Pijus, Mandal, Brooke A, Meyers, Faika, Mseeh, Connor A, Parker, Simon S, Yu, Christopher C, Williams, Qi, Wu, Maria Emilia, Di Francesco, Giulio, Draetta, Timothy, Heffernan, Joseph R, Marszalek, Nancy E, Kohl, Philip, Jones
Publikováno v:
Journal of medicinal chemistry. 64(20)
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in RTK-mediated resistance, making the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef1c5b3d344a33f3d6564080b26ff7f2
https://pubmed.ncbi.nlm.nih.gov/34643390
https://pubmed.ncbi.nlm.nih.gov/34643390
Autor:
Michael J. Soth, Kang Le, Maria Emilia Di Francesco, Matthew M. Hamilton, Gang Liu, Jason P. Burke, Chris L. Carroll, Jeffrey J. Kovacs, Jennifer P. Bardenhagen, Christopher A. Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R. Garvey, Jason P. Gay, Mary K. Geck Do, Jennifer Greer, Michelle Han, Angela Harris, Zachary Herrera, Sha Huang, Virginia Giuliani, Yongying Jiang, Sarah B. Johnson, Troy A. Johnson, Zhijun Kang, Paul G. Leonard, Zhen Liu, Timothy McAfoos, Meredith Miller, Pietro Morlacchi, Robert A. Mullinax, Wylie S. Palmer, Jihai Pang, Norma Rogers, Charles M. Rudin, Hannah E. Shepard, Nakia D. Spencer, Jay Theroff, Qi Wu, Alan Xu, Ju Anne Yau, Giulio Draetta, Carlo Toniatti, Timothy P. Heffernan, Philip Jones
Publikováno v:
J Med Chem
Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical properties. We initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b9f179f30ccdc7840fbbad768ec366
https://europepmc.org/articles/PMC9007139/
https://europepmc.org/articles/PMC9007139/
Autor:
Philip Jones, Timothy P. Heffernan, Natalya Nazarenko, Carlo Toniatti, Giulio Draetta, Anne Yau, Quanyun Xu, Jay Theroff, Nakia D. Spencer, Hannah Shepard, Norma Rogers, Jihai Pang, Wylie S. Palmer, Pietro Morlacchi, Meredith Miller, Timothy McAfoos, Zhen Liu, Zhijun Kang, Troy Johnson, Yongying Jiang, Sha Huang, Virginia Giuliani, Angela Harris, Mary Geck Do, Matthew M . Hamilton, Maria E. Di Francesco, Chris Carroll, Barbara Czako, Christopher Bristow, Jennifer Bardenhagen, Jason P. Burke, Jeffrey J. Kovacs, Gang Liu, Kang Le, Dr. Michael Soth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd6e4734b698474034c7af62ef1da54
https://doi.org/10.1021/scimeetings.0c03462
https://doi.org/10.1021/scimeetings.0c03462
Autor:
Alessia Petrocchi, Naphtali J. Reyna, Faika Mseeh, Connor A. Parker, Simon Yu, Quanyun Xu, Ningping Feng, Paul Leonard, Norma Rogers, Jason B. Cross, Angela L. Harris, Yongying Jiang, Tin Oo Khor, Mikhila G. Mahendra, Jihai Pang, Qi Wu, Andy M. Zuniga, Timothy McAfoos, Matthew M. Hamilton, Joe R. Marszalek, Keith Mikule, Paul Vancutsem, Keith Wilcoxen, Martin Tremblay, Philip Jones, Richard T. Lewis
Publikováno v:
Cancer Research. 78:LB-071
Indoleamine 2,3-dioxygenase (IDO1 and IDO2) and tryptophan dioxygenase (TDO) are heme-containing enzymes that mediate the rate limiting step in the oxidative degradation of L-tryptophan (L-TRP) to kynurenine (KYN) metabolites. Tryptophan catabolism t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0efdf3558a82bc49107b3bec62cbd8
https://doi.org/10.1158/1538-7445.am2018-lb-071
https://doi.org/10.1158/1538-7445.am2018-lb-071
Autor:
Florian L. Muller, Stefan O. Ciurea, Christopher Carroll, Lina Han, Sergej Konoplev, Timothy P. Heffernan, M. Emilia Di Francesco, Yuting Sun, Polina Matre, Quanyun Xu, Tin Oo Khor, Michael Peoples, John de Groot, Melinda Smith, Sha Huang, Verlene Henry, John M. Asara, Zhijun Kang, Edward F. Chang, Carlo Toniatti, Angela K. Deem, Riccardo Serreli, Yoko Tabe, Virginia Giuliani, Yongying Jiang, Timothy Lofton, Ronald A. DePinho, Helen Ma, Naval Daver, Jennifer Greer, Jennifer R. Molina, Madhavi Bandi, Cross Jason, Pietro Morlacchi, Jing Han, Thomas Shi, Guang Gao, Barbara Czako, Gang Liu, Marina Konopleva, Christopher A. Bristow, Jeffrey J. Ackroyd, Philip Jones, Jay Theroff, Marina Protopopova, Ningping Feng, Alessia Petrocchi, Mikhila Mahendra, Stefano Tiziani, Sonal Gera, Jennifer Bardenhagen, Yu Hsi Lin, Robert A. Mullinax, Qi Zhang, Joseph R. Marszalek, Mary Geck Do, Judy Hirst, Timothy McAfoos, Ahmed Noor A. Agip, Gheath Alatrash, Alessia Lodi, Caroline C. Carrillo, Jaime Rodriguez-Canale, Jian Wen Dong, Giulio Draetta
Publikováno v:
Nature medicine. 24(7)
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad09c63c598436e334643a51ef79183
https://pubmed.ncbi.nlm.nih.gov/29892070
https://pubmed.ncbi.nlm.nih.gov/29892070
Autor:
Maria Emilia Di Francesco, Joseph R. Marszalek, Timothy McAfoos, Christopher L. Carroll, Zhijun Kang, Gang Liu, Jay P. Theroff, Jennifer P. Bardenhager, Madhavi L. Bandi, Jennifer R. Molina, Sonal Gera, Marina Protopopova, Yuting Sun, Mary K. Geck Do, Ningping Feng, Jason P. Gay, Florian Muller, Marina Konopleva, Funda Meric-Bernstam, Carlo Toniatti, Timothy P. Heffernan, Giulio F. Draetta, Philip Jones
Publikováno v:
Cancer Research. 78:1655-1655
Over the past few years we and others reported that specific populations of tumor cells including AML, subsets of lymphoma, glioblastoma, triple negative breast cancer (TNBC), melanoma and pancreatic ductal adenocarcinoma (PDAC) are highly dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4543bcb4ba8f50d568dec9cd0decabeb
https://doi.org/10.1158/1538-7445.am2018-1655
https://doi.org/10.1158/1538-7445.am2018-1655
Autor:
Jennifer Molina, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Christopher Carroll, Edward Chang, Jason Cross, Naval Daver, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Jing Han, Judy Hirst, Sha Huang, Yongying Jiang, Zhijun Kang, Marina Konopleva, Gang Liu, Helen Ma, Polina Matre, Timothy McAfoos, Funda Meric-Bernstam, Pietro Morlacchi, Florian Muller, Marina Protopopova, Melinda Smith, Sonal Sonal, Yuting Sun, Jay Theroff, Andrea Viale, Quanyun Xu, Carlo Toniatti, Giulio Draetta, Philip Jones, M. Emilia Di Francesco, Joseph R. Marszalek
Publikováno v:
Cancer Research. 77:4971-4971
Tumor cells depend on both glycolysis and oxidative phosphorylation (OXPHOS) for energy and biomass production to support cell proliferation. Recent data has demonstrated a dependence of various tumor types on mitochondrial OXPHOS, which represents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec5af0900ed7a5a7874a207e7393d5a8
https://doi.org/10.1158/1538-7445.am2017-4971
https://doi.org/10.1158/1538-7445.am2017-4971