Výsledky vyhledávání - "Timothy, Donahue"

Akademický článek

Disparities in neoadjuvant chemotherapy for pancreatic adenocarcinoma with vascular involvement

Autor: Nikhil Chervu, Shineui Kim, Sara Sakowitz, Nguyen Le, Saad Mallick, Hanjoo Lee, Peyman Benharash, Timothy Donahue

Publikováno v: Surgery Open Science, Vol 20, Iss , Pp 101-105 (2024)

Background: Multiagent neoadjuvant chemotherapy (NAT) has been linked with improved survival for locally advanced (LA) or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC). However, the existence of disparities in its utilization rem

Externí odkaz: https://doaj.org/article/220fd89c146b46008678221e4fc1f85f

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Akademický článek

From Scalpel to Scope: How Surgical Techniques Made Way for State-of-The-Art Endoscopic Procedures

Autor: Firas Bahdi, Amanda Labora, Sagar Shah, Maryam Farooq, Peerapol Wangrattanapranee, Timothy Donahue, Danny Issa

Publikováno v: Gastro Hep Advances, Vol 3, Iss 3, Pp 370-384 (2024)

The continuous evolution of endoscopic tools over the years has paved the way for minimally invasive alternatives to surgical procedures for multiple gastrointestinal conditions. While few endoscopic techniques have supplanted their surgical counterp

Externí odkaz: https://doaj.org/article/4839e1dce0e3424699f3739307f9be2e

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Akademický článek

Establishing a mouse model of lung metastases using ultrasound-guided right heart ventricle injection

Autor: Amanda Labora, Amanda Creech, Hailey Lee, Erin Tabornal, Caius Radu, Timothy Donahue

Publikováno v: STAR Protocols, Vol 4, Iss 4, Pp 102698- (2023)

Summary: We report a technique to generate a murine model of lung metastases by selectively injecting tumor cells into the right heart ventricle under ultrasound guidance. First, we describe cell preparation and reference animal preparation as previo

Externí odkaz: https://doaj.org/article/204bb58dab9e4c09891036aee959b777

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Akademický článek

Generation of liver metastases in a mouse model using ultrasound-guided intravenous injection

Autor: Amanda Labora, Hailey Lee, Charlotte Chan, Erin Tabornal, Thuc Le, Khalid Rashid, Evan Abt, Takanobu Yamao, Hanna Mandl, Amanda Creech, Alykhan Premji, Luyi Li, Jason Link, Nanping Wu, Caius Radu, Timothy Donahue

Publikováno v: STAR Protocols, Vol 4, Iss 2, Pp 102163- (2023)

Summary: Here, we present a protocol to generate a murine model of liver metastasis by directly injecting tumor cells into the portal vein under ultrasound guidance. We describe steps for animal and cell preparation and two techniques for injecting t

Externí odkaz: https://doaj.org/article/787b8b63ca1e445d89bfaf62678f140f

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Akademický článek

Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment

Autor: Ying Ji, Xiangsheng Liu, Juan Li, Xiaodong Xie, Max Huang, Jinhong Jiang, Yu-Pei Liao, Timothy Donahue, Huan Meng

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). Here, the authors use ratiometrically designed nanoparticles to codeliver the CDK4/6 inhibitor palb

Externí odkaz: https://doaj.org/article/43701da3f8494ba7a8e1565db285cedd

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