Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Timotheus Y.F. Halim"'
Autor:
Maryam Ghaedi, Catherine A. Steer, Itziar Martinez-Gonzalez, Timotheus Y.F. Halim, Ninan Abraham, Fumio Takei
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 471-480 (2016)
All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we
Externí odkaz:
https://doaj.org/article/3bcc3aa0acce4789bcc6a9bb4c397fc1
Autor:
Munetomo Takahashi, Tsz Y. So, Kate Williamson, Zhaleh Hosseini, Katarzyna Kania, Michelle Ruhle, Tiffeney Mann, Martijn J. Schujis, Paul Coupland, Dean Naisbitt, Timotheus Y.F. Halim, Paul A. Lyons, Pietro Lio, Klaus Okkenhaug, David J. Adams, Ken G.C. Smith, Duncan I. Jodrell, Michael A. Chapman, James E. D. Thaventhiran
Tissue homeostasis is maintained by the behaviours of lymphocyte clones responding to antigenic triggers in the face of pathogen, environmental, and developmental challenges. Current methodologies for tracking the behaviour of specific lymphocytes id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e52c41c56409441949bd279e56eaf6
https://doi.org/10.1101/2023.03.16.532070
https://doi.org/10.1101/2023.03.16.532070
Autor:
Charlotte J. Imianowski, Sarah K. Whiteside, Teresa Lozano, Alexander C. Evans, Jayme D. Benson, Christina J.F. Courreges, Firas Sadiyah, Colleen M. Lau, Nordin D. Zandhuis, Francis M. Grant, Martijn J. Schuijs, Panagiota Vardaka, Paula Kuo, Elizabeth J. Soilleux, Jie Yang, Joseph C. Sun, Tomohiro Kurosaki, Klaus Okkenhaug, Timotheus Y.F. Halim, Rahul Roychoudhuri
Publikováno v:
Journal of Experimental Medicine. 219
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. Mechanisms by which NK cells remain quiescent in ti
Autor:
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y.F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Publikováno v:
Journal of Experimental Medicine. 219
Autor:
Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan, Liam Cassidy, Marta Poblocka, Haoran Zhu, Aaron Lun, Martijn Schuijs, Andrew Young, Celia Martinez-Jimenez, Timotheus Y.F. Halim, Shishir Shetty, Masashi Narita, Matthew Hoare
Publikováno v:
Genes Dev. 36, 533-549 (2022)
Funder: National Institute for Health and Care Research
Funder: Diabetes UK
Funder: BIRAX
Senescence is a stress-responsive tumor suppressor mechanism associated with expression of the senescence-associated secretory phenotype (SASP).
Funder: Diabetes UK
Funder: BIRAX
Senescence is a stress-responsive tumor suppressor mechanism associated with expression of the senescence-associated secretory phenotype (SASP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b400dc537a6ec48b0c6b5dd6dad94e97
Autor:
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y.F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Publikováno v:
JOURNAL OF EXPERIMENTAL MEDICINE
Funder: Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
Funder: Alzheimer's Association
Funder: European Research Council
Funder: Fondation pour l’Aide à la Recherche sur la Sclérose en Plaques
Funder: Vetens
Funder: Alzheimer's Association
Funder: European Research Council
Funder: Fondation pour l’Aide à la Recherche sur la Sclérose en Plaques
Funder: Vetens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff38c09def949c44dafdb80179d4c709
https://doi.org/10.1084/jem.20212391
https://doi.org/10.1084/jem.20212391
Autor:
Timotheus Y.F. Halim, Shwethaa Raghunathan, Tobias Janowitz, Erwin F. Wagner, Martijn J. Schuijs, Duncan I. Jodrell, Michele Petruzzelli, Michele Vacca, Christian Frezza, Zoe Hall, David Perera, Edoardo Gaude, Miriam Ferrer, Ashok R. Venkitaraman, Michael J. Lukey
An elevated neutrophil-to-lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, we show using murine model systems of colorectal and pancreatic cancer that neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d1675fc35cbbd4f83849c18c3ee51c
https://doi.org/10.1101/2021.08.11.455851
https://doi.org/10.1101/2021.08.11.455851
Autor:
Silvain Pinaud, Karsten Bach, Marija Zarocsinceva, Sacha J Howell, Sara Pensa, Carlos Caldas, Katarzyna D. Kania, Bruno M Simões, John C. Marioni, Alice R. Greenhalgh, Julie Stockis, Mona Shehata, Walid T. Khaled, Kyren A. Lazarus, Timotheus Y.F. Halim, Robert Clarke
Publikováno v:
Bach, K, Pensa, S, Zarocsinceva, M, Kania, K, Stockis, J, Pinaud, S, Lazarus, K A, Shehata, M, Simões, B M, Greenhalgh, A R, Howell, S J, Clarke, R B, Caldas, C, Halim, T Y F, Marioni, J C & Khaled, W T 2021, ' Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors ', Nature Communications, vol. 12, no. 1 . https://doi.org/10.1038/s41467-021-21783-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known about how BRCA1 loss-of-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24be004e59da16b4cf960b7624ca74bc
Autor:
Oliver T. Burton, Tino Hochepied, Carlos P. Roca, Félix Lombard-Vadnais, Adrian Liston, Kailash Singh, Alena Moudra, Meryem Aloulou, Francisco J. Naranjo, James Dooley, Timotheus Y.F. Halim, Sylvie Lesage, Carly E. Whyte, Lubna Kouser, Susan M. Schlenner
Interleukin 2 (IL-2) is a key homeostatic cytokine, with potential therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical application has been hampered by pleiotropic functionality and wide-spread receptor expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4132ed651c3551b982dd32fb50756a98
https://doi.org/10.1101/2020.12.18.423431
https://doi.org/10.1101/2020.12.18.423431
Autor:
David Rafei-Shamsabadi, Karolina Ebert, Yakup Tanriver, Stefan F. Martin, Sebastian J. Arnold, Saskia van de Poel, Christoph S.N. Klose, Britta Dorn, Andreas Diefenbach, Timotheus Y.F. Halim, Thilo Jakob, Andrew N. J. McKenzie, Stefanie Kunz
Publikováno v:
The Journal of Investigative Dermatology
Allergic contact dermatitis and its animal model, contact hypersensitivity, are T-cell-mediated inflammatory skin diseases that require activation of the innate immune system. Here we investigate the role of innate lymphoid cells (ILCs) during the el