Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Timothée Lionnet"'
Autor:
Alon Kalo, Itamar Kanter, Amit Shraga, Jonathan Sheinberger, Hadar Tzemach, Noa Kinor, Robert H. Singer, Timothée Lionnet, Yaron Shav-Tal
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 419-432 (2015)
The transcriptional response of β-actin to extra-cellular stimuli is a paradigm for transcription factor complex assembly and regulation. Serum induction leads to a precisely timed pulse of β-actin transcription in the cell population. Actin protei
Externí odkaz:
https://doaj.org/article/1bbd4d4d9d534e809ada382ad6b88c81
Autor:
Sudarshan Pinglay, Milica Bulajić, Dylan P. Rahe, Emily Huang, Ran Brosh, Nicholas E. Mamrak, Benjamin R. King, Sergei German, John A. Cadley, Lila Rieber, Nicole Easo, Timothée Lionnet, Shaun Mahony, Matthew T. Maurano, Liam J. Holt, Esteban O. Mazzoni, Jef D. Boeke
Publikováno v:
Science
INTRODUCTION: Despite an ever-expanding catalog of noncoding elements that are implicated in the control of mammalian gene expression, how the regulatory input from multiple elements is integrated across a genomic neighborhood has remained largely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7772d22daf61c45f770cf5e49e7233
https://doi.org/10.1126/science.abk2820
https://doi.org/10.1126/science.abk2820
Autor:
Nicholas E Mamrak, Nader Alerasool, Daniel Griffith, Alex S Holehouse, Mikko Taipale, Timothée Lionnet
Cell-to-cell variability is shaped by transcription dynamics because genes are transcribed in bursts interspersed with inactive periods. The stochasticity of bursting means that genes transcribed in rare bursts exhibit more heterogeneity at the singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec105ea0409f5a075626843d82287701
https://doi.org/10.1101/2022.06.01.494187
https://doi.org/10.1101/2022.06.01.494187
Autor:
Timothée Lionnet, Carl Wu
Publikováno v:
Curr Opin Genet Dev
A universe of transcription factors (TFs), cofactors, as well as chromatin remodeling and modifying enzymes combine or compete on chromatin to control transcription. Measuring quantitatively how these proteins dynamically interact is required in orde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f9f6f03a4104189b1535c2a7d70d4a
https://doi.org/10.1016/j.gde.2020.12.001
https://doi.org/10.1016/j.gde.2020.12.001
Autor:
Won-Ki Cho, Namrata Jayanth, Brian P English, Takuma Inoue, J Owen Andrews, William Conway, Jonathan B Grimm, Jan-Hendrik Spille, Luke D Lavis, Timothée Lionnet, Ibrahim I Cisse
Publikováno v:
eLife, Vol 5 (2016)
Protein clustering is a hallmark of genome regulation in mammalian cells. However, the dynamic molecular processes involved make it difficult to correlate clustering with functional consequences in vivo. We developed a live-cell super-resolution appr
Externí odkaz:
https://doaj.org/article/492d9368f0144434aab5205106f266e9
Autor:
Zachary B Katz, Brian P English, Timothée Lionnet, Young J Yoon, Nilah Monnier, Ben Ovryn, Mark Bathe, Robert H Singer
Publikováno v:
eLife, Vol 5 (2016)
Messenger RNA localization is important for cell motility by local protein translation. However, while single mRNAs can be imaged and their movements tracked in single cells, it has not yet been possible to determine whether these mRNAs are actively
Externí odkaz:
https://doaj.org/article/46e36cf08f3d447aaa02922fcc3821f4
Autor:
Tony T. Huang, Kalanghad Puthankalam Srinivas, Timothée Lionnet, Daniel P. Depledge, Moses V. Chao, Hui-Lan Hu, Shuoshuo Wang, Angus C. Wilson, Ian Mohr
Publikováno v:
EMBO Rep
Single‐cell RNA sequencing (scRNA‐seq) is a powerful technique for dissecting the complexity of normal and diseased tissues, enabling characterization of cell diversity and heterogeneous phenotypic states in unprecedented detail. However, this te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871581eaa5034fba1e7c51d4bad26c3c
https://doi.org/10.15252/embr.202153543
https://doi.org/10.15252/embr.202153543
Autor:
K. Kolyvanov, Ella Bahry, M. Zouinkhi, Timothée Lionnet, Leo Epstein, Stephan Preibisch, Kyle Harrington, Xi Long, Laura Breimann
Fluorescent in-situ hybridization (FISH)-based methods are powerful tools to study molecular processes with subcellular resolution, relying on accurate identification and localization of diffraction-limited spots in microscopy images. We developed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f593516f69b9bd3aa2cd09743492f828
https://doi.org/10.21203/rs.3.rs-992563/v1
https://doi.org/10.21203/rs.3.rs-992563/v1
Autor:
Ella Bahry, Laura Breimann, Marwan Zouinkhi, Leo Epstein, Klim Kolyvanov, Nicholas Mamrak, Benjamin King, Xi Long, Kyle I. S. Harrington, Timothée Lionnet, Stephan Preibisch
Publikováno v:
Nature methods. 19(12)
Fluorescent in-situ hybridization (FISH)-based methods extract spatially resolved genetic and epigenetic information from biological samples by detecting fluorescent spots in microscopy images, an often challenging task. We present Radial Symmetry-FI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cba0361e6910a8fdefb337d11085626
https://pubmed.ncbi.nlm.nih.gov/36396787
https://pubmed.ncbi.nlm.nih.gov/36396787
Autor:
Luke D. Lavis, Xiaona Tang, Pat Visanpattanasin, Sheng Liu, Jonathan Snedeker, Kai Yu Li, Carl Wu, Timothée Lionnet, Qinsi Zheng, Vivian Jou, Jee Min Kim
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Conserved ATP-dependent chromatin remodelers establish and maintain genome-wide chromatin architectures of regulatory DNA during cellular lifespan, but the temporal interactions between remodelers and chromatin targets have been obscure. We performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27a169897bf60814adb0e04eb5acc98
https://doi.org/10.1101/2021.04.21.440742
https://doi.org/10.1101/2021.04.21.440742