Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Autor: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R B Perry, Xin Yuan, Robert A Scott, Peter Henneman, Iris M Heid, Jorge R Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger, Toshiko Tanaka, Andrew P Morris, Kerrin Small, Aaron Isaacs, Marian Beekman, Stefan Coassin, Kurt Lohman, Lu Qi, Stavroula Kanoni, James S Pankow, Hae-Won Uh, Ying Wu, Aurelian Bidulescu, Laura J Rasmussen-Torvik, Celia M T Greenwood, Martin Ladouceur, Jonna Grimsby, Alisa K Manning, Ching-Ti Liu, Jaspal Kooner, Vincent E Mooser, Peter Vollenweider, Karen A Kapur, John Chambers, Nicholas J Wareham, Claudia Langenberg, Rune Frants, Ko Willems-Vandijk, Ben A Oostra, Sara M Willems, Claudia Lamina, Thomas W Winkler, Bruce M Psaty, Russell P Tracy, Jennifer Brody, Ida Chen, Jorma Viikari, Mika Kähönen, Peter P Pramstaller, David M Evans, Beate St Pourcain, Naveed Sattar, Andrew R Wood, Stefania Bandinelli, Olga D Carlson, Josephine M Egan, Stefan Böhringer, Diana van Heemst, Lyudmyla Kedenko, Kati Kristiansson, Marja-Liisa Nuotio, Britt-Marie Loo, Tamara Harris, Melissa Garcia, Alka Kanaya, Margot Haun, Norman Klopp, H-Erich Wichmann, Panos Deloukas, Efi Katsareli, David J Couper, Bruce B Duncan, Margreet Kloppenburg, Linda S Adair, Judith B Borja, DIAGRAM+ Consortium, MAGIC Consortium, GLGC Investigators, MuTHER Consortium, James G Wilson, Solomon Musani, Xiuqing Guo, Toby Johnson, Robert Semple, Tanya M Teslovich, Matthew A Allison, Susan Redline, Sarah G Buxbaum, Karen L Mohlke, Ingrid Meulenbelt, Christie M Ballantyne, George V Dedoussis, Frank B Hu, Yongmei Liu, Bernhard Paulweber, Timothy D Spector, P Eline Slagboom, Luigi Ferrucci, Antti Jula, Markus Perola, Olli Raitakari, Jose C Florez, Veikko Salomaa, Johan G Eriksson, Timothy M Frayling, Andrew A Hicks, Terho Lehtimäki, George Davey Smith, David S Siscovick, Florian Kronenberg, Cornelia van Duijn, Ruth J F Loos, Dawn M Waterworth, James B Meigs, Josee Dupuis, J Brent Richards, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Soumya Raychaudhuri, Steve A McCarroll, Oliver M Hofmann, Ayellet V Segrè, Mandy van Hoek, Pau Navarro, Kristin Ardlie, Beverley Balkau, Rafn Benediktsson, Amanda J Bennett, Roza Blagieva, Eric Boerwinkle, Lori L Bonnycastle, Kristina Bengtsson Boström, Bert Bravenboer, Suzannah Bumpstead, Noël P Burtt, Guillaume Charpentier, Peter S Chines, Marilyn Cornelis, Gabe Crawford, Alex S F Doney, Katherine S Elliott, Amanda L Elliott, Michael R Erdos, Caroline S Fox, Christopher S Franklin, Martha Ganser, Christian Gieger, Niels Grarup, Todd Green, Simon Griffin, Christopher J Groves, Candace Guiducci, Samy Hadjadj, Neelam Hassanali, Christian Herder, Bo Isomaa, Anne U Jackson, Paul R V Johnson, Torben Jørgensen, Wen H L Kao, Augustine Kong, Peter Kraft, Johanna Kuusisto, Torsten Lauritzen, Man Li, Aloysius Lieverse, Cecilia M Lindgren, Valeriya Lyssenko, Michel Marre, Thomas Meitinger, Kristian Midthjell, Mario A Morken, Narisu Narisu, Peter Nilsson, Katharine R Owen, Felicity Payne, Ann-Kristin Petersen, Carl Platou, Christine Proença, Inga Prokopenko, Wolfgang Rathmann, N William Rayner, Neil R Robertson, Ghislain Rocheleau, Michael Roden, Michael J Sampson, Richa Saxena, Beverley M Shields, Peter Shrader, Gunnar Sigurdsson, Thomas Sparsø, Klaus Strassburger, Heather M Stringham, Qi Sun, Amy J Swift, Barbara Thorand, Jean Tichet, Tiinamaija Tuomi, Rob M van Dam, Timon W van Haeften, Thijs van Herpt, Jana V van Vliet-Ostaptchouk, G Bragi Walters, Michael N Weedon, Cisca Wijmenga, Jacqueline Witteman, Richard N Bergman, Stephane Cauchi, Francis S Collins, Anna L Gloyn, Ulf Gyllensten, Torben Hansen, Winston A Hide, Graham A Hitman, Albert Hofman, David J Hunter, Kristian Hveem, Markku Laakso, Andrew D Morris, Colin N A Palmer, Igor Rudan, Eric Sijbrands, Lincoln D Stein, Jaakko Tuomilehto, Andre Uitterlinden, Mark Walker, Richard M Watanabe, Goncalo R Abecasis, Bernhard O Boehm, Harry Campbell, Mark J Daly, Andrew T Hattersley, Oluf Pedersen, Inês Barroso, Leif Groop, Rob Sladek, Unnur Thorsteinsdottir, James F Wilson, Thomas Illig, Philippe Froguel, Cornelia M van Duijn, Kari Stefansson, David Altshuler, Michael Boehnke, Mark I McCarthy, Nicole Soranzo, Eleanor Wheeler, Nicole L Glazer, Nabila Bouatia-Naji, Reedik Mägi, Joshua Randall, Paul Elliott, Denis Rybin, Abbas Dehghan, Jouke Jan Hottenga, Kijoung Song, Anuj Goel, Taina Lajunen, Alex Doney, Christine Cavalcanti-Proença, Meena Kumari, Nicholas J Timpson, Carina Zabena, Erik Ingelsson, Ping An, Jeffrey O'Connell, Jian'an Luan, Amanda Elliott, Steven A McCarroll, Rosa Maria Roccasecca, François Pattou, Praveen Sethupathy, Yavuz Ariyurek, Philip Barter, John P Beilby, Yoav Ben-Shlomo, Sven Bergmann, Murielle Bochud, Amélie Bonnefond, Knut Borch-Johnsen, Yvonne Böttcher, Eric Brunner, Suzannah J Bumpstead, Yii-Der Ida Chen, Peter Chines, Robert Clarke, Lachlan J M Coin, Matthew N Cooper, Laura Crisponi, Ian N M Day, Eco J C de Geus, Jerome Delplanque, Annette C Fedson, Antje Fischer-Rosinsky, Nita G Forouhi, Maria Grazia Franzosi, Pilar Galan, Mark O Goodarzi, Jürgen Graessler, Scott Grundy, Rhian Gwilliam, Göran Hallmans, Naomi Hammond, Xijing Han, Anna-Liisa Hartikainen, Caroline Hayward, Simon C Heath, Serge Hercberg, David R Hillman, Aroon D Hingorani, Jennie Hui, Joe Hung, Marika Kaakinen, Jaakko Kaprio, Y Antero Kesaniemi, Mika Kivimaki, Beatrice Knight, Seppo Koskinen, Peter Kovacs, Kirsten Ohm Kyvik, G Mark Lathrop, Debbie A Lawlor, Olivier Le Bacquer, Cécile Lecoeur, Yun Li, Robert Mahley, Massimo Mangino, María Teresa Martínez-Larrad, Jarred B McAteer, Ruth McPherson, Christa Meisinger, David Melzer, David Meyre, Braxton D Mitchell, Sutapa Mukherjee, Silvia Naitza, Matthew J Neville, Marco Orrù, Ruth Pakyz, Giuseppe Paolisso, Cristian Pattaro, Daniel Pearson, John F Peden, Nancy L Pedersen, Andreas F H Pfeiffer, Irene Pichler, Ozren Polasek, Danielle Posthuma, Simon C Potter, Anneli Pouta, Michael A Province, Nigel W Rayner, Kenneth Rice, Samuli Ripatti, Fernando Rivadeneira, Olov Rolandsson, Annelli Sandbaek, Manjinder Sandhu, Serena Sanna, Avan Aihie Sayer, Paul Scheet, Udo Seedorf, Stephen J Sharp, Beverley Shields, Gunnar Sigurðsson, Eric J G Sijbrands, Angela Silveira, Laila Simpson, Andrew Singleton, Nicholas L Smith, Ulla Sovio, Amy Swift, Holly Syddall, Ann-Christine Syvänen, Anke Tönjes, André G Uitterlinden, Ko Willems van Dijk, Dhiraj Varma, Sophie Visvikis-Siest, Veronique Vitart, Nicole Vogelzangs, Gérard Waeber, Peter J Wagner, Andrew Walley, Kim L Ward, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, Jaqueline C M Witteman, John W G Yarnell, Diana Zelenika, Björn Zethelius, Guangju Zhai, Jing Hua Zhao, M Carola Zillikens, DIAGRAM Consortium, GIANT Consortium, Global B Pgen Consortium, Ingrid B Borecki, Pierre Meneton, Patrik K E Magnusson, David M Nathan, Gordon H Williams, Kaisa Silander, Stefan R Bornstein, Peter Schwarz, Joachim Spranger, Fredrik Karpe, Alan R Shuldiner, Cyrus Cooper, Manuel Serrano-Ríos, Lars Lind, Lyle J Palmer, Paul W Franks, Shah Ebrahim, Michael Marmot, W H Linda Kao, Peter Paul Pramstaller, Alan F Wright, Michael Stumvoll, Anders Hamsten, Procardis Consortium, Thomas A Buchanan, Timo T Valle, Jerome I Rotter, Brenda W J H Penninx, Dorret I Boomsma, Antonio Cao, Angelo Scuteri, David Schlessinger, Manuela Uda, Aimo Ruokonen, Marjo-Riitta Jarvelin, Leena Peltonen, Vincent Mooser, Robert Sladek, MAGIC investigators, GLGC Consortium, Kiran Musunuru, Albert V Smith, Andrew C Edmondson, Ioannis M Stylianou, Masahiro Koseki, James P Pirruccello, Daniel I Chasman, Christopher T Johansen, Sigrid W Fouchier, Gina M Peloso, Maja Barbalic, Sally L Ricketts, Joshua C Bis, Mary F Feitosa, Marju Orho-Melander, Olle Melander, Xiaohui Li, Mingyao Li, Yoon Shin Cho, Min Jin Go, Young Jin Kim, Jong-Young Lee, Taesung Park, Kyunga Kim, Xueling Sim, Rick Twee-Hee Ong, Damien C Croteau-Chonka, Leslie A Lange, Joshua D Smith, Andreas Ziegler, Weihua Zhang, Robert Y L Zee, John B Whitfield, John R Thompson, Ida Surakka, Tim D Spector, Johannes H Smit, Juha Sinisalo, James Scott, Juha Saharinen, Chiara Sabatti, Lynda M Rose, Robert Roberts, Mark Rieder, Alex N Parker, Guillaume Pare, Christopher J O'Donnell, Markku S Nieminen, Deborah A Nickerson, Grant W Montgomery, Wendy McArdle, David Masson, Nicholas G Martin, Fabio Marroni, Gavin Lucas, Robert Luben, Marja-Liisa Lokki, Guillaume Lettre, Lenore J Launer, Edward G Lakatta, Reijo Laaksonen, Kirsten O Kyvik, Inke R König, Kay-Tee Khaw, Lee M Kaplan, Åsa Johansson, A Cecile J W Janssens, Wilmar Igl, G Kees Hovingh, Christian Hengstenberg, Aki S Havulinna, Nicholas D Hastie, Tamara B Harris, Talin Haritunians, Alistair S Hall, Leif C Groop, Elena Gonzalez, Nelson B Freimer, Jeanette Erdmann, Kenechi G Ejebe, Angela Döring, Anna F Dominiczak, Serkalem Demissie, Panagiotis Deloukas, Ulf de Faire, Gabriel Crawford, Yii-der I Chen, Mark J Caulfield, S Matthijs Boekholdt, Themistocles L Assimes, Thomas Quertermous, Mark Seielstad, Tien Y Wong, E-Shyong Tai, Alan B Feranil, Christopher W Kuzawa, Herman A Taylor, Stacey B Gabriel, Hilma Holm, Vilmundur Gudnason, Ronald M Krauss, Jose M Ordovas, Patricia B Munroe, Jaspal S Kooner, Alan R Tall, Robert A Hegele, John J P Kastelein, Eric E Schadt, David P Strachan, Muredach P Reilly, Nilesh J Samani, Heribert Schunkert, L Adrienne Cupples, Manjinder S Sandhu, Paul M Ridker, Daniel J Rader, Sekar Kathiresan

Publikováno v: PLoS Genetics, Vol 8, Iss 3, p e1002607 (2012)

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide associati

Externí odkaz: https://doaj.org/article/d72a07536f4c468e8ab94500a1e663a5

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp.

Autor: Jana V van Vliet-Ostaptchouk, Timon W van Haeften, Gijs W D Landman, Erwin Reiling, Nanne Kleefstra, Henk J G Bilo, Olaf H Klungel, Anthonius de Boer, Cleo C van Diemen, Cisca Wijmenga, H Marike Boezen, Jacqueline M Dekker, Esther van 't Riet, Giel Nijpels, Laura M C Welschen, Hata Zavrelova, Elinda J Bruin, Clara C Elbers, Florianne Bauer, N Charlotte Onland-Moret, Yvonne T van der Schouw, Diederick E Grobbee, Annemieke M W Spijkerman, Daphne L van der A, Annemarie M Simonis-Bik, Elisabeth M W Eekhoff, Michaela Diamant, Mark H H Kramer, Dorret I Boomsma, Eco J de Geus, Gonneke Willemsen, P Eline Slagboom, Marten H Hofker, Leen M 't Hart

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32148 (2012)

BACKGROUND:Genome-wide association studies in Japanese populations recently identified common variants in the KCNQ1 gene to be associated with type 2 diabetes. We examined the association of these variants within KCNQ1 with type 2 diabetes in a Dutch

Externí odkaz: https://doaj.org/article/9ad5fb82e74d460cbe4a3a4b682811c2

A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants

Autor: Jaakko Tuomilehto, Lorena Boquete-Vilarino, Andrea Natali, Robert L. Hanson, Anny H. Xiang, Markku Laakso, Nicholette D. Palmer, Donald W. Bowden, Ewan R. Pearson, Oluf Pedersen, Leen M 't Hart, Jussi Paananen, Francis S. Collins, Anne U. Jackson, Mark I. McCarthy, Dorret I. Boomsma, Richard M. Watanabe, Karina Banasik, Nienke van Leewen, Anette P. Gjesing, Christopher J. Groves, Andreas Fritsche, Timon W. van Haeften, Karen L. Mohlke, Michael Boehnke, Anubha Mahajan, Nan Wang, Lynne E. Wagenknecht, Mark H. H. Kramer, Jill M. Norris, Timothy M. Frayling, Andrew R. Wood, Alena Stančáková, Annemarie M. C. Simonis-Bik, Giel Nijpels, Eco J. C. de Geus, Leslie J. Baier, Andrea Mari, Kent D. Taylor, Torben Hansen, Niels Grarup, Thomas A. Buchanan, Anna Jonsson, Elisabeth M. W. Eekhoff, Hans Eiberg, Richard N. Bergman, Mark Walker, Sayuko Kobes, Joris Deelen, Yii-Derr Chen, Ulf Smith

Publikováno v: Diabetes
Diabetes, 66(8), 2296-2309. American Diabetes Association Inc.
Diabetes, 66(8), 2296-2309
Wood, A R, Jonsson, A, Jackson, A U, Wang, N, Van Leewen, N, Palmer, N D, Kobes, S, Deelen, J, Boquete-Vilarino, L, Paananen, J, Stancáková, A, Boomsma, D I, De Geus, E J C, Eekhoff, E M W, Fritsche, A, Kramer, M, Nijpels, G, Simonis-Bik, A, Van Haeften, T W, Mahajan, A, Boehnke, M, Bergman, R N, Tuomilehto, J, Collins, F S, Mohlke, K L, Banasik, K, Groves, C J, McCarthy, M I, Pearson, E R, Natali, A, Mari, A, Buchanan, T A, Taylor, K D, Xiang, A H, Gjesing, A P, Grarup, N, Eiberg, H, Pedersen, O, Chen, Y D, Laakso, M, Norris, J M, Smith, U, Wagenknecht, L E, Baier, L, Bowden, D W, Hansen, T, Walker, M, Watanabe, R M, T'Hart, L M, Hanson, R L & Frayling, T M 2017, ' A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants ', Diabetes, vol. 66, no. 8, pp. 2296-2309 . https://doi.org/10.2337/db16-1452
Wood, A R, Jonsson, A, Jackson, A U, Wang, N, van Leewen, N, Palmer, N D, Kobes, S, Deelen, J, Boquete-Vilarino, L, Paananen, J, Stančáková, A, Boomsma, D I, de Geus, J C N, Eekhoff, E M, Fritsche, A, Kramer, M H H, Nijpels, G, Simonis-Bik, A M C, van Haeften, T W, Mahajan, A, Boehnke, M, Bergman, R N, Tuomilehto, J, Collins, F S, Mohlke, K L, Banasik, K, Groves, C J, McCarthy, M I, Pearson, E R, Natali, A, Mari, A, Buchanan, T A, Taylor, K D, Xiang, A H, Gjesing, A P, Grarup, N, Eiberg, H, Pedersen, O, Chen, Y-D, Laakso, M, Norris, J M, Smith, U, Wagenknecht, L E, Baier, L, Bowden, D W, Hansen, T, Walker, M, Watanabe, R M, 't Hart, L M, Hanson, R L & Frayling, T M 2017, ' A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants ', Diabetes, vol. 66, no. 8, pp. 2296-2309 . https://doi.org/10.2337/db16-1452

Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7b51ddcab370edaf0f233fdda53dfb
http://hdl.handle.net/11568/885333

Platelet Tissue Factor Synthesis in Type 2 Diabetic Patients Is Resistant to Inhibition by Insulin

Autor: Cornelis A. Koekman, Timon W. van Haeften, Anja J. Gerrits, Jan Willem N. Akkerman

Publikováno v: Diabetes

OBJECTIVE Patients with type 2 diabetes have an increased risk of cardiovascular disease and show abnormalities in the coagulation cascade. We investigated whether increased synthesis of tissue factor (TF) by platelets could contribute to the hyperco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1ff34c31d773c040c06ea9322ac327
https://doi.org/10.2337/db09-1008

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function

Autor: Dorret I. Boomsma, P. Eline Slagboom, Gonneke Willemsen, Mark H.H. Kramer, Erwin Reiling, Elisabeth M. W. Eekhoff, Eco J. C. de Geus, Leen M 't Hart, Michaela Diamant, Jacqueline M. Dekker, Giel Nijpels, A.M.C. Simonis-Bik, Jeanine J. Houwing-Duistermaat, Timon W. van Haeften, Els C. van Hove, J. Antonie Maassen, Robert J. Heine

Publikováno v: Diabetes
Diabetes, 59(1), 293-301
Bik-Simonis, A M C, Nijpels, M G A A M, van Haeften, T, Houwing-Duistermaat, J J, Boomsma, D I, Reiling, E, van Hove, E C, Diamant, M, Kramer, M H H, Heine, R J, Maassen, J A, Slagboom, P E, Willemsen, G, Dekker, J M, Eekhoff, E M W, de Geus, E J C & Hart, L M 2010, ' Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta cell function ', Diabetes, vol. 59, no. 1, pp. 293-301 . https://doi.org/10.2337/db09-1048
Diabetes, 59(1), 293-301. American Diabetes Association Inc.

OBJECTIVE Recently, results from a meta-analysis of genome-wide association studies have yielded a number of novel type 2 diabetes loci. However, conflicting results have been published regarding their effects on insulin secretion and insulin sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712dee0a9c0be2d7d41b244de6dfba12
http://europepmc.org/articles/PMC2797936