Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Timo Wirth"'
Autor:
I-Na Lu, Phyllis Fung-Yi Cheung, Michael Heming, Christian Thomas, Giovanni Giglio, Markus Leo, Merve Erdemir, Timo Wirth, Simone König, Christine A. Dambietz, Christina B. Schroeter, Christopher Nelke, Jens T. Siveke, Tobias Ruck, Luisa Klotz, Carmen Haider, Romana Höftberger, Christoph Kleinschnitz, Heinz Wiendl, Tim Hagenacker, Gerd Meyer zu Horste
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract 5q-associated spinal muscular atrophy (SMA) is a motoneuron disease caused by mutations in the survival motor neuron 1 (SMN1) gene. Adaptive immunity may contribute to SMA as described in other motoneuron diseases, yet mechanisms remain elus
Externí odkaz:
https://doaj.org/article/fb6284ab7fac4a1d86c729a732971fab
Autor:
Valerie E. Teschner, Ann-Katrin Fleck, Carolin Walter, Anna-Sophie Schwarze, Melanie Eschborn, Timo Wirth, Olga V. Steinberg, Andreas Schulte-Mecklenbeck, I-Na Lu, Marisol Herrera-Rivero, Claudia Janoschka, Jan D. Lünemann, Nicholas Schwab, Gerd Meyer zu Hörste, Julian Varghese, Catharina C. Gross, Refik Pul, Christoph Kleinschnitz, Simone Mader, Edgar Meinl, Monika Stoll, Heinz Wiendl, Luisa Klotz
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background: Cladribine is a highly effective immunotherapy that is applied in two short-term courses over 2 years and reduces relapse rate and disease progression in patients with relapsing multiple sclerosis (MS). Despite the short treatment period,
Externí odkaz:
https://doaj.org/article/620f3b4ae03d47ceb2b1381faa850bb4
Autor:
Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl, Sven G. Meuth
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Objective Intravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up to one quarter of patients. Immunoadsorption is an accepted treatment for refractory relapses,
Externí odkaz:
https://doaj.org/article/0a0e3ada0a514fe3a64b5d0f52371427
Autor:
Sinah Engel, Luisa Klotz, Timo Wirth, Ann-Katrin Fleck, Geethanjali Pickert, Melanie Eschborn, Samia Kreuzburg, Valentina Curella, Stefan Bittner, Frauke Zipp, Detlef Schuppan, Felix Luessi
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background: Western lifestyle has been associated with an increase in relapsing–remitting multiple sclerosis (RRMS). In mice, dietary wheat amylase–trypsin inhibitors (ATIs) activate intestinal myeloid cells and augment T cell-mediated systemic i
Externí odkaz:
https://doaj.org/article/eb2f34d3276f4369ad0fffda96a8ba92
Autor:
Susan Trümpelmann, Andreas Schulte‐Mecklenbeck, Olga V. Steinberg, Timo Wirth, Manfred Fobker, Lisa Lohmann, Jan D. Lünemann, Heinz Wiendl, Catharina C. Gross, Luisa Klotz
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1606-1612 (2022)
Abstract The impact of distinct disease‐modifying therapies (DMTs) on severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccination efficacy in patients with multiple sclerosis (MS) is still enigmatic. In this prospective comparati
Externí odkaz:
https://doaj.org/article/f05537ce2aae4b02889d23972f4c5898
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
Here, the authors demonstrate intra-cavity excitation and time-domain sampling of coherent optical phonons inside an active laser oscillator. They discover that Terahertz crystal vibrations link successive ultrashort solitons which offers an approach
Externí odkaz:
https://doaj.org/article/511737f5885242599a75a3a7524d6ffb
Autor:
Toni Weinhage, Timo Wirth, Paula Schütz, Philipp Becker, Aloys Lueken, Boris V. Skryabin, Helmut Wittkowski, Dirk Foell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute
Externí odkaz:
https://doaj.org/article/d8837fd0bfc24332817bb5dad0e379c5
Autor:
Lisa Lohmann, Claudia Janoschka, Andreas Schulte-Mecklenbeck, Svenja Klinsing, Lucienne Kirstein, Uta Hanning, Timo Wirth, Tilman Schneider-Hohendorf, Nicholas Schwab, Catharina C. Gross, Maria Eveslage, Sven G. Meuth, Heinz Wiendl, Luisa Klotz
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Leukocyte sequestration is an established therapeutic concept in multiple sclerosis (MS) as represented by the trafficking drugs natalizumab (NAT) and fingolimod (FTY). However, the precise consequences of targeting immune cell trafficking for immuno
Externí odkaz:
https://doaj.org/article/046805c628ff4743a45c351b9b412785
Autor:
Toni Weinhage, Jan Däbritz, Anne Brockhausen, Timo Wirth, Markus Brückner, Michael Belz, Dirk Foell, Georg Varga
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 4, Pp 433-449.e1 (2015)
Background & Aims: Granulocyte macrophage colony-stimulating factor (GM-CSF) treatment induces clinical response in patients with active Crohnâs disease. To explore whether monocytes mediate GM-CSF effects in vivo, we used a mouse model of chronic
Externí odkaz:
https://doaj.org/article/ae58de7ac6944813800007a7352d9d4f
Autor:
Catharina C. Gross, Andreas Schulte-Mecklenbeck, Olga V. Steinberg, Timo Wirth, Sarah Lauks, Sergio E. Baranzini, Stefan Bittner, Judith Bellmann-Strobl, Nora Bünger, Eva Eilers, Maria Eveslage, Vinzenz Fleischer, Barbara Gisevius, Sergiu Groppa, Jürgen Haas, Martin Kerschensteiner, Lucienne Kirstein, Catharina Korsukewitz, Lisa Lohmann, Jan Lünemann, Felix Lüssi, Gerd Meyerzu Hörste, Jeremias Motte, Tobias Ruck, Nicholas Schwab, Sven G. Meuth, Friedemann Paul, Brigitte Wildemann, Tania Kümpfel, Ralf Gold, Frauke Zipp, Luisa Klotz, Heinz Wiendl
Publikováno v:
Sunday, April 23.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5277adba6fa99a17409399b89bb875
https://doi.org/10.1212/wnl.0000000000203461
https://doi.org/10.1212/wnl.0000000000203461