Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

Autor: Katty Zeven, Timo W.M. De Groof, Hannelore Ceuppens, Robin Maximilian Awad, Thomas Ertveldt, Wout de Mey, Fien Meeus, Geert Raes, Karine Breckpot, Nick Devoogdt

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionT cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies. Despite the emergence

Externí odkaz: https://doaj.org/article/051a7b27d7524e158560ba763978542a

Emerging applications of nanobodies in cancer therapy

Autor: Robin Maximilian Awad, Fien Meeus, Hannelore Ceuppens, Thomas Ertveldt, Heleen Hanssens, Quentin Lecocq, Lukasz Mateusiak, Katty Zeven, Hana Valenta, Timo W.M. De Groof, Yannick De Vlaeminck, Ahmet Krasniqi, Kim De Veirman, Cleo Goyvaerts, Matthias D’Huyvetter, Sophie Hernot, Nick Devoogdt, Karine Breckpot

Publikováno v: International Review of Cell and Molecular Biology ISBN: 9780323994026

Cancer is a heterogeneous disease, requiring treatment tailored to the unique phenotype of the patient's tumor. Monoclonal antibodies (mAbs) and variants thereof have enabled targeted therapies to selectively target cancer cells. Cancer cell-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0636d89d1e257c4da1729af4dc922
https://hdl.handle.net/20.500.14017/6cc85c4b-bc3c-420a-bb01-3676231bbb60

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

Autor: Nick D. Bergkamp, Martine J. Smit, Truc Giap, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Timo W.M. De Groof, Maarten P. Bebelman, Richard de Goeij de Haas, Raimond Heukers, Sander R. Piersma, Marco Siderius

Publikováno v: Nature Communications
Nature Communications, 12(1):4357. Nature Publishing Group
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, pp. 4357 . https://doi.org/10.1038/s41467-021-24574-y
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 12(1). Nature Publishing Group UK
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, 4357 . https://doi.org/10.1038/s41467-021-24574-y

While various GPCRs, including US28, display constitutive, ligand-independent activity, it remains to be established whether ligand-dependent and -independent active conformations differ and can be selectively modulated. Previously, the agonist-bound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34630bbac1bf5a3229244884d5e7a47
http://europepmc.org/articles/PMC8285524

Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases

Autor: Raimond Heukers, John Sinclair, Elizabeth G. Elder, Marco Siderius, Martine J. Smit, Timo W.M. De Groof

Publikováno v: De Groof, T W M, Elder, E G, Siderius, M, Heukers, R, Sinclair, J H & Smit, M J 2021, ' Viral G Protein-Coupled Receptors : Attractive Targets for Herpesvirus-Associated Diseases ', Pharmacological reviews, vol. 73, no. 2, pp. 828-846 . https://doi.org/10.1124/pharmrev.120.000186

Herpesviruses are ubiquitous pathogens that establish lifelong, latent infections in their host. Spontaneous reactivation of herpesviruses is often asymptomatic or clinically manageable in healthy individuals, but reactivation events in immunocomprom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189b1f301d3f5c9796d14e33764a658c
https://doi.org/10.1124/pharmrev.120.000186

Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor

Autor: Nick Devoogdt, Timo W.M. De Groof, Serge Muyldermans, Raf Van Campenhout, Mathieu Vinken

Publikováno v: Biomolecules
Biomolecules, Vol 11, Iss 63, p 63 (2021)

Cell plasma membrane proteins are considered as gatekeepers of the cell and play a major role in regulating various processes. Transport proteins constitute a subclass of cell plasma membrane proteins enabling the exchange of molecules and ions betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51bc3254a2b3a7f18814164821f1157
https://hdl.handle.net/20.500.14017/44de61c6-e1db-4dbc-b30a-4e291d6132f5