Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Timo Viitamaa"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract α2‐Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α2‐adrenoceptor agonist developed especially as a spinal analgesic. The current studies
Externí odkaz:
https://doaj.org/article/03043c47ea0f4626a0455857cd6103e5
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 380:539-550
The present experiments compared the peripheral and central pharmacological effects of three alpha(2)-adrenoceptor agonists: fadolmidine, clonidine, and dexmedetomidine after single intrathecal bolus injections at analgesic dose level in rats. Effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947e3a1570a0c5426d0e850a6d359f0e
https://doi.org/10.1007/s00210-009-0460-6
https://doi.org/10.1007/s00210-009-0460-6
Autor:
Ari Koivisto, Raimo Virtanen, Tiina Leino, Tarja Lehtimäki, Katja Kuokkanen, Antti Haapalinna, Jyrki Lehtimäki, Timo Viitamaa
Publikováno v:
European Journal of Pharmacology. 599:65-71
Alpha2-adrenergic receptors (alpha2-adrenoceptors) mediate various physiological actions of endogenous catecholamines in the central and peripheral nervous systems being involved in alertness, heart rate regulation, vasomotor control and nociceptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d75ffb9f895407c38b5f8a3d0104204
https://doi.org/10.1016/j.ejphar.2008.10.003
https://doi.org/10.1016/j.ejphar.2008.10.003
Publikováno v:
Pharmacology Biochemistry and Behavior. 83:360-369
The purpose of the present series of experiments was to determine whether drugs acting at the alpha2-adrenoceptor modify unconditioned sexual incentive motivation in the male rat. To that end a highly specific agonist, dexmedetomidine, a correspondin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57572822cabb4300c6cbbbb6cc38ca47
https://doi.org/10.1016/j.pbb.2006.02.015
https://doi.org/10.1016/j.pbb.2006.02.015
Autor:
Janne Lähdesmäki, M Pelto-Huikko, Mika Scheinin, Antti Haapalinna, E Rybnikova, Brian K. Kobilka, Jukka Sallinen, Timo Viitamaa, Ewen MacDonald
Publikováno v:
Molecular Psychiatry. 4:443-452
alpha2-Adrenoceptors (alpha2-AR) modulate many central nervous system functions, such as regulation of sympathetic tone, vigilance, attention, and reactivity to environmental stressors. Three alpha2-AR subtypes (alpha2A, alpha2B, and alpha2C) with di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a302d56fe16f349600fdacfaeaac20
https://doi.org/10.1038/sj.mp.4000543
https://doi.org/10.1038/sj.mp.4000543
Publikováno v:
The Journal of Neuroscience. 18:3035-3042
Studies on animal models of stress, anxiety, aggression, and sensorimotor gating have linked specific monoamine neurotransmitter abnormalities to the cognitive and behavioral disturbances associated with many affective neuropsychiatric disorders. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932cbcb1087f17b4c5d8aede4802ab45
https://doi.org/10.1523/jneurosci.18-08-03035.1998
https://doi.org/10.1523/jneurosci.18-08-03035.1998
Autor:
Juha-Matti Savola, Ewen MacDonald, Timo Viitamaa, Leena Tuomisto, Raimo Virtanen, Esa Heinonen, Antti Haapalinna
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 356:570-582
In the present study we evaluated the alpha 1- and alpha 2-adrenoceptor subtype binding, central alpha 2-adrenoceptor antagonist potency, as well as effects on brain neurochemistry and behavioural pharmacology of two alpha 2-adrenoceptor antagonists,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d95d62fb17812d6f983111d59dcdf73
https://doi.org/10.1007/pl00005092
https://doi.org/10.1007/pl00005092
Autor:
Gregory S. Barsh, Richard E. Link, Timo Viitamaa, Antti Haapalinna, Tiina Leino, Birgitta Sjöholm, Ewen MacDonald, Brian K. Kobilka, Maya Kulatunga, Markku Pelto-Huikko, Mika Scheinin, Jukka Sallinen
Publikováno v:
Molecular Pharmacology. 51:36-46
alpha 2-Adrenergic receptors (alpha 2-ARs) regulate many physiological functions and are targets for clinically important antihypertensive and anesthetic agents. Three human and mouse genes encoding alpha 2-AR subtypes (alpha 2A, alpha 2B, and alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1b83c463777bd72c8ed2b5783e98fc
https://doi.org/10.1124/mol.51.1.36
https://doi.org/10.1124/mol.51.1.36
Publikováno v:
Scopus-Elsevier
Neuroleptics are known to cause anhedonia and attenuate sexual behaviour at therapeutic doses in humans. These effects are assumed to result from the dopamine antagonism of the drugs. It has been observed that a mixed dopamine D1/D2 antagonist, halop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b8d043aa4bc61b48f18d907fd81b9c
https://pubmed.ncbi.nlm.nih.gov/10401732
https://pubmed.ncbi.nlm.nih.gov/10401732
Autor:
Antti Haapalinna, Jarmo S. Salonen, Jouni Sirviö, Raimo Virtanen, Timo Viitamaa, Ewen MacDonald
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 359(3)
The effects of an alpha2-adrenoceptor antagonist, atipamezole, on exploratory behaviour in a novel environment, spontaneous motor activity and active avoidance learning were studied after acute injection and continuous infusion (0.1 mg/kg h) for 24 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5547b4ef068420314369b13dc155b03
https://pubmed.ncbi.nlm.nih.gov/10208306
https://pubmed.ncbi.nlm.nih.gov/10208306