Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Timo S. Spehl"'
Autor:
Ralph Buchert, Catharina Lange, Timo S. Spehl, Ivayla Apostolova, Lars Frings, Cathrine Jonsson, Philipp T. Meyer, Sabine Hellwig
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Introduction The specific uptake size index (SUSI) of striatal FP-CIT uptake is independent of spatial resolution in the SPECT image, in contrast to the specific binding ratio (SBR). This suggests that the SUSI is particularly appropriate fo
Externí odkaz:
https://doaj.org/article/b9b0053d4aae43289ba40e7dd23955dd
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 45:1442-1448
The value of imaging regional glucose metabolism with [18F]FDG PET for the prediction of progression from mild cognitive impairment (MCI) to Alzheimer’s dementia (AD) is controversial. The predictive value of imaging with [18F]FDG PET was therefore
Publikováno v:
Current Alzheimer Research. 13:678-681
Naming impairment in Alzheimer’s disease dementia (AD) is associated with atrophy of the left anterior temporal lobe (ATL). We aimed to elucidate if regional cerebral glucose metabolism, as a biomarker of synaptic dysfunction and neurodegeneration,
Autor:
F. Braun, Luciano Furlanetti, Lars Frings, Volker A. Coenen, Philipp T. Meyer, S. Thiele, M. Ferch, Máté D. Döbrössy, Timo S. Spehl, Amir H. Rezvani
Publikováno v:
Behavioural Brain Research. 300:11-24
The etiology of depression is unknown but has been associated with dysregulation of neuronal activity at numerous loci on the limbic-cortical circuitry. The Flinders Sensitive Line (FSL) is a validated rodent model of human depression with spontaneou
Autor:
Niuscha Yaktapour, Thorsten Zenz, Justin Mastroianni, Philipp T. Meyer, Stefan Fröhling, Katja Zirlik, Barbara Hutter, Robert Zeiser, Benedikt Brors, Frank Meiss, Timo S. Spehl, Dietmar Pfeifer, Rainer Claus, Justus Duyster, Nimitha R. Mathew, Tilman Brummer, Ingrid Bartsch, Hana Andrlová, Milena Pantic
Publikováno v:
Journal of Clinical Investigation. 124:5074-5084
Patients with BRAFV600E/K-driven melanoma respond to the BRAF inhibitor vemurafenib due to subsequent deactivation of the proliferative RAS/RAF/MEK/ERK pathway. In BRAF WT cells and those with mutations that activate or result in high levels of the B
Autor:
Christian Winkler, Wolfgang A. Weber, Volkmar Glauche, Annabelle Kreft, Oliver Tüscher, Philipp T. Meyer, Bernhard Hellwig, Florian Amtage, Michel Rijntjes, Cornelius Weiller, Timo S. Spehl, Sabine Hellwig
Publikováno v:
Clinical Nuclear Medicine. 39:319-325
Progressive supranuclear palsy (PSP) is characterized by a symmetric hypokinetic syndrome with early falls and vertical supranuclear gaze palsy. However, clinically asymmetric manifestations occur, resembling idiopathic Parkinson disease or corticoba
Autor:
Cornelius Weiller, Philipp T. Meyer, Timo S. Spehl, Michael Hüll, Lars Frings, Florian Amtage, Sabine Hellwig, Wolfgang A. Weber, Tobias Bormann
Publikováno v:
Journal of Neuroimaging. 25:281-288
BACKGROUND Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome with visuospatial deficits. PET studies have identified hypometabolism of the occipital cortex in PCA. There is, however, a huge overlap in clinical presentation and inv
Autor:
Lars Frings, Sabine Hellwig, Timo S. Spehl, Tobias Bormann, Annabelle Kreft, Oliver Tüscher, Florian Amtage, Cornelius Weiller, Philipp T. Meyer
Publikováno v:
Brain and Language. 127:307-314
We investigated disease-specific cognitive profiles and their neural correlates in Lewy-body diseases (LBD) and tauopathies by CERAD assessment and FDG-PET. Analyses revealed a significant interaction between reduced semantic fluency in tauopathies a
Publikováno v:
Journal of Nuclear Medicine. 54:1909-1914
Amyloid-b (Ab) deposition is a pathologic hallmark of Alzheimer disease (AD). Although the typical spatial distribution pattern of Ab deposition in early AD mainly involves regions distant from the hippocampus, the predominant clinical feature is imp
Autor:
Birgitta Metternich, Andreas Schulze-Bonhage, Michael Trippel, Timo S. Spehl, Isabell Ofer, Franziska Buschmann, Philipp T. Meyer, Horst Urbach, Kathrin Wagner, Lars Frings
Publikováno v:
Epilepsia. 58
Summary The clinical appearance of patients with hypothalamic hamartomas is very heterogeneous, and interindividual variability of intellectual abilities is not completely understood. We retrospectively investigated cerebral dysfunction as indicated