Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Timo Rieg"'
Autor:
Linto Thomas, Lashodya V. Dissanayake, Maryam Tahmasbi, Alexander Staruschenko, Sima Al-Masri, Jessica A. Dominguez Rieg, Timo Rieg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Vitamin D3 is clinically used for the treatment of vitamin D3 deficiency or osteoporosis, partially because of its role in regulating phosphate (Pi) and calcium (Ca2+) homeostasis. The renal sodium-phosphate cotransporter 2a (Npt2a) plays an
Externí odkaz:
https://doaj.org/article/5bacf6cc89e742b9b6f470f6ef8bb7fa
Autor:
Olha Kravtsova, Vladislav Levchenko, Christine A. Klemens, Timo Rieg, Ruisheng Liu, Alexander Staruschenko
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Sodium-glucose co-transporters (SGLTs) in the kidneys play a pivotal role in glucose reabsorption. Several clinical and population-based studies revealed the beneficial effects of SGLT2 inhibition on hypertension. Recent work from our lab pr
Externí odkaz:
https://doaj.org/article/9f1f4c743494479a95a83a2fc0a994a0
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Arginine vasopressin (AVP) induces an increase in intracellular Ca2+ concentration ([Ca2+]i) with an oscillatory pattern in isolated perfused kidney inner medullary collecting duct (IMCD). The AVP-induced Ca2+ mobilization in inner medullary collecti
Externí odkaz:
https://doaj.org/article/88f8d24aeeed4a3b8e25059fc459d2aa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
In the intestine, the Na+/H+ exchanger 3 (NHE3) plays a critical role for Na+ and fluid absorption. NHE3 deficiency predisposes patients to inflammatory bowel disease (IBD). In mice, selective deletion of intestinal NHE3 causes various local and syst
Externí odkaz:
https://doaj.org/article/58b30e40531a4f348b1a38f9cc394c3f
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244251 (2020)
The connexin 37 (Cx37) channel is clustered at gap junctions between cells in the renal vasculature or the renal tubule where it is abundant in basolateral cell interdigitations and infoldings of epithelial cells in the proximal tubule, thick ascendi
Externí odkaz:
https://doaj.org/article/ca1b54c5436741a48940a1818d460b7d
Publikováno v:
Revista Cubana de Investigaciones Biomédicas, Vol 38, Iss 5 (2020)
Introduction: Hyperphosphatemia is common in patients with chronic kidney disease and associated with increased mortality. Oral phosphate binders and dietary phosphate restriction are the current management protocols for patients with hyperphosphatem
Externí odkaz:
https://doaj.org/article/dd428a15acb743f29849df37913b355d
Autor:
Olha, Kravtsova, Ruslan, Bohovyk, Vladislav, Levchenko, Oleg, Palygin, Christine A, Klemens, Timo, Rieg, Alexander, Staruschenko
Publikováno v:
Am J Physiol Renal Physiol
Na(+)-glucose cotransporter-2 (SGLT2) inhibitors are the new mainstay of treatment for diabetes mellitus and cardiovascular diseases. Despite the remarkable benefits, the molecular mechanisms mediating the effects of SGLT2 inhibitors on water and ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1514c1f9bb6dcd6d10a1e31cad04a8b
https://pubmed.ncbi.nlm.nih.gov/35466690
https://pubmed.ncbi.nlm.nih.gov/35466690
Publikováno v:
Xue, J, Thomas, L, Dominguez Rieg, J A, Fenton, R A & Rieg, T 2022, ' NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification ', American journal of physiology. Renal physiology, vol. 323, no. 2, pp. F141-F155 . https://doi.org/10.1152/ajprenal.00013.2022
The Na +/H + exchanger isoform 3 (NHE3) facilitates Na + reabsorption and H + secretion by the kidneys. Despite stronger NHE3 abundance in the thick ascending limb (TAL) compared to the S1 and S2 segments of the proximal tubule, the role of NHE3 in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f719b2cd5b52a1f14da21602577a80d
https://doi.org/10.1152/ajprenal.00013.2022
https://doi.org/10.1152/ajprenal.00013.2022
Publikováno v:
Current Opinion in Nephrology & Hypertension. 31:486-492
Targeting sodium phosphate cotransporter 2a (Npt2a) offers a novel strategy for treating hyperphosphatemia in chronic kidney disease (CKD). Here we review recent studies on the efficacy of Npt2a inhibition, its plasma phosphate (Pi)-lowering effects,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31394a2f60779abd545fa033c9da289
https://doi.org/10.1097/mnh.0000000000000828
https://doi.org/10.1097/mnh.0000000000000828
Autor:
Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F692-F707
The present study indicates that Na+-glucose cotransporter-2 (SGLT2) inhibition in a nondiabetic model of salt-sensitive hypertension blunts the development and magnitude of salt-induced hypertension. Chronic inhibition of SGLT2 increases glucose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d71e689c8d8325799c1518bf02e9e36
https://doi.org/10.1152/ajprenal.00053.2022
https://doi.org/10.1152/ajprenal.00053.2022