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Autor:
Andreas Luch, Christoph Hutzler, Udo Bock, Susanne Trappe, Joep Brinkmann, Timo Otter, Kristin Stolpmann, Frank Henkler, Manfred Liebsch, Doris Genkinger
Publikováno v:
Toxicological Sciences
The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) is formed to certain extents. Skin is frequently in co