Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Timo Koivula"'
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:460-464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaec46664b0cf9c6180f7a62aaab2c3b
https://doi.org/10.1111/j.1600-0773.1977.tb02098.x
https://doi.org/10.1111/j.1600-0773.1977.tb02098.x
Autor:
Timo Koivula, Arja Nenonen, Riikka Mäkelä, Heini Huhtala, Michele Mercuri, Antti Loimaala, Gene Bond, Ilkka Vuori, Pekka Oja, Terho Lehtimäki
Publikováno v:
Clinical Biochemistry. 41:532-537
Objectives Type 2 diabetes mellitus (DM) enhances the development of atherosclerosis and reduces the activity of the oxidative myeloperoxidase (MPO) enzyme. MPO gene has a functional promoter polymorphism −463G/A which leads to high- (GG) and low-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73d961287ed0c6cd734e5e05b6937ed
https://doi.org/10.1016/j.clinbiochem.2008.01.017
https://doi.org/10.1016/j.clinbiochem.2008.01.017
Autor:
M. Ukkonen, Mikko Hurme, Heini Huhtala, Irina Elovaara, Timo Koivula, Mari Luomala, Terho Lehtimäki
Publikováno v:
Acta Neurologica Scandinavica. 108:396-400
Functional polymorphisms of the genes for interleukin-10 (IL-10; promoter position -1082), chemokine receptor-5 (CCR5 32 bp deletion), tumor necrous factor-α (TNFα promoter position -308) and cytotoxic T-lymphocyte antigen-4 (CTLA-4 exon I position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf1a48f72138723a56c5e19303728f0
https://doi.org/10.1034/j.1600-0404.2003.00165.x
https://doi.org/10.1034/j.1600-0404.2003.00165.x
Autor:
Päivi Hämelahti, Otso Järvinen, Terho Lehtimäki, Erkki Ilveskoski, Timo Koivula, Tero Sisto, Valtteri Wirta
Publikováno v:
European Journal of Clinical Investigation. 32:869-873
Background The C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene leads to C/C, C/T and T/T genotypes, which affect the plasma homocysteine concentration in humans. In mini-pigs, high serum homocysteine levels are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29510cc6868d9e3133f5bea30a925ba6
https://doi.org/10.1046/j.1365-2362.2002.01050.x
https://doi.org/10.1046/j.1365-2362.2002.01050.x
Autor:
Perttu J. Pöllänen, Markus Perola, Timo Koivula, Pekka J. Karhunen, Erkki Ilveskoski, Antti Penttilä, Seppo T. Nikkari, Kirsi Syrjäkoski, Kari M. Mattila, Pekka Laippala, Jussi Mikkelsson, Olli A. Kajander, Sirkka Goebeler, Terho Lehtimäki
Publikováno v:
Atherosclerosis. 164:329-335
Matrix metalloproteinase 3 (MMP3) is expressed in human coronary atherosclerotic lesions and is known to be involved in degradation of the plaque and to be co-localized with calcium and fibrin deposits in advanced lesions, indicating a possible role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfad00dfb902f82e2dd9a116536675fd
https://doi.org/10.1016/s0021-9150(02)00107-7
https://doi.org/10.1016/s0021-9150(02)00107-7
Autor:
Juha Laakso, Risto Vesalainen, Olli Jaakkola, Juhani Knuuti, Kari M. Mattila, Reijo Laaksonen, Timo Koivula, Pirjo Nuutila, Terho Lehtimäki, Tuula Janatuinen
Publikováno v:
European Journal of Clinical Investigation. 32:400-404
Background Oxidised low-density lipoprotein (ox-LDL) is a determinant of impaired coronary function and oestrogens inhibit its formation probably throughout genetically-variable oestrogen receptor 1 (ESR1) in artery wall. We hypothesized that the ESR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd31b29be4a75c1104098d747ad8deb0
https://doi.org/10.1046/j.1365-2362.2002.01010.x
https://doi.org/10.1046/j.1365-2362.2002.01010.x
Autor:
Terho Lehtimäki, Timo Koivula, Hannu Jokela, Olli Jaakkola, Reijo Punnonen, T A Koivu, Seppo T. Nikkari, Prasun Dastidar
Publikováno v:
Atherosclerosis. 157:471-479
Background: In epidemiologic studies, the incidence of atherosclerosis rises soon after menopause in women, and hormone replacement therapy (HRT) has proved to be useful in preventing onset of clinical manifestations of the disease. However, it is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa1b68c0b020bb926e9b141c01a6de8
https://doi.org/10.1016/s0021-9150(00)00751-6
https://doi.org/10.1016/s0021-9150(00)00751-6
Publikováno v:
Atherosclerosis. 157:301-307
Paraoxonase (PON) is an antioxidative enzyme, which eliminates lipid peroxides. PON has two common polymorphisms (M/L55 and R/Q192) that influence PON concentration and activity. We studied whether the M/L55 or R/Q192 genotype relates with the severi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39121c3681696b7d4f79fd533f3dc85e
https://doi.org/10.1016/s0021-9150(00)00728-0
https://doi.org/10.1016/s0021-9150(00)00728-0
Autor:
T A Koivu, Anne Kalela, Hannu Alho, Pekka Sillanaukee, Timo Koivula, Seppo T. Nikkari, Hannu Jokela
Publikováno v:
European Journal of Clinical Investigation. 31:581-585
Background Elevated serum homocysteine concentrations have been related to coronary heart disease. However, the association has not indisputably been proven, and the mechanisms by which homocysteine may be atherogenic have only partially been elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc523484cb5a716203089762f2c409ef
https://doi.org/10.1046/j.1365-2362.2001.00853.x
https://doi.org/10.1046/j.1365-2362.2001.00853.x
Autor:
Juhani Knuuti, Pirjo Nuutila, Yue-Mei Fan, Terho Lehtimäki, Tuula Janatuinen, Reijo Laaksonen, Risto Vesalainen, Timo Koivula
Publikováno v:
European Journal of Clinical Investigation. 31:574-580
Background Impaired coronary flow reserve (CFR) can be used to indicate vascular dysfunction before the appearance of angiographic lesions. The hepatic lipase (HL) gene has a functional promoter polymorphism at position C-480T, which affects transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ac70816a8639001e587a42a855b33f1
https://doi.org/10.1046/j.1365-2362.2001.00858.x
https://doi.org/10.1046/j.1365-2362.2001.00858.x