Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timo E.S. Kauppila"'
Autor:
Francesca Baggio, Sebastian Grönke, Linda Partridge, Nils-Göran Larsson, Ana Bratic, Timo E.S. Kauppila, Martin Borch Jensen, Heinrich Jasper
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Mutations of mtDNA accumulate in aging humans and other mammals to cause mitochondrial dysfunction in a subset of cells in various tissues. Furthermore, experimental induction of mtDNA mutations causes a premature aging syndrome in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa15771d730ee70714f4d4206b982ab
https://hdl.handle.net/21.11116/0000-000B-47CF-D
https://hdl.handle.net/21.11116/0000-000B-47CF-D
Autor:
Nils-Göran Larsson, Arnaud Mourier, James B. Stewart, Marita A Isokallio, Alexandra Just, Nina A. Bonekamp, Timo E.S. Kauppila, Johanna H.K. Kauppila
Publikováno v:
Nucleic Acids Res
Nucleic Acids Research
Nucleic Acids Research
Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c573661e5b5b4505a9cbc7e6f5147f1
https://hdl.handle.net/21.11116/0000-0004-720F-C
https://hdl.handle.net/21.11116/0000-0004-720F-C
Publikováno v:
Cell Metab
Mitochondria were first postulated to contribute to aging more than 40 years ago. During the following decades, multiple lines of evidence in model organisms and humans showed that impaired mitochondrial function can contribute to age-associated dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f94769961d4ffae9587ed90a40baaae
https://pubmed.ncbi.nlm.nih.gov/28094012
https://pubmed.ncbi.nlm.nih.gov/28094012
Autor:
Linda Partridge, Sebastian Grönke, Francesca Baggio, Anna Wredenberg, Ana Bratic, James B. Stewart, Timo E.S. Kauppila, Bertil Macao, Maria Falkenberg, Nils-Göran Larsson, Triinu Siibak, Jacqueline Dols
Publikováno v:
Nat Commun
Nature Communications
Nature Communications
Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520b7e5628f7de7a3332ee0ae9f6d1a3
https://hdl.handle.net/21.11116/0000-000B-A99C-7
https://hdl.handle.net/21.11116/0000-000B-A99C-7
Autor:
Kat Folz-Donahue, Ilian Atanassov, James B. Stewart, Sara Albarran-Gutierrez, Xinping Li, Nils-Göran Larsson, Min Jiang, Timo E.S. Kauppila, Nina A. Bonekamp, Elisa Motori
Publikováno v:
Cell Metab
Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00a289efde3d84fbbd0a89a5675223b
https://doi.org/10.1016/j.cmet.2017.07.003
https://doi.org/10.1016/j.cmet.2017.07.003
Autor:
Linda Partridge, Ana Bratic, Nils-Göran Larsson, Francesca Baggio, Arnaud Mourier, Luke S Tain, Timo E.S. Kauppila, Bianca Habermann, Christian Kukat
Publikováno v:
NUCLEIC ACIDS RESEARCH
Nucleic Acids Research
Nucleic Acids Res
Nucleic Acids Research
Nucleic Acids Res
Members of the pentatricopeptide repeat domain (PPR) protein family bind RNA and are important for post-transcriptional control of organelle gene expression in unicellular eukaryotes, metazoans and plants. They also have a role in human pathology, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea97e8118c7448549338b319f0b7438f
https://hdl.handle.net/11858/00-001M-0000-0024-C492-711858/00-001M-0000-0024-C494-3
https://hdl.handle.net/11858/00-001M-0000-0024-C492-711858/00-001M-0000-0024-C494-3
Autor:
Triinu Siibak, Paula Clemente, Ana Bratic, Helene Bruhn, Timo E.S. Kauppila, Bertil Macao, Florian A. Schober, Nicole Lesko, Rolf Wibom, Karin Naess, Inger Nennesmo, Anna Wedell, Bradley Peter, Christoph Freyer, Maria Falkenberg, Anna Wredenberg
Publikováno v:
Human Molecular Genetics
Hum Mol Genet
Hum Mol Genet
Mutations in the mitochondrial DNA polymerase, POLG, are associated with a variety of clinical presentations, ranging from early onset fatal brain disease in Alpers syndrome to chronic progressive external ophthalmoplegia. The majority of mutations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d9e8ca0f78a2ceca21292114ab226e3e