Multiscale approaches to protein-mediated interactions between membranes—relating microscopic and macroscopic dynamics in radially growing adhesions

Autor: Timo Bihr, Udo Seifert, Ana-Sunčana Smith

Publikováno v: New Journal of Physics, Vol 17, Iss 8, p 083016 (2015)

Macromolecular complexation leading to coupling of two or more cellular membranes is a crucial step in a number of biological functions of the cell. While other mechanisms may also play a role, adhesion always involves the fluctuations of deformable

Externí odkaz: https://doaj.org/article/f2378dd9adbd4893a99c9c428292a9ca

Membrane fluctuations mediate lateral interaction between cadherin bonds

Autor: Rudolf Merkel, Udo Seifert, Susanne F. Fenz, Ana-Sunčana Smith, Timo Bihr, Kheya Sengupta, Daniel Schmidt

Publikováno v: Nature physics 13, 906–913 (2017). doi:10.1038/nphys4138
Nature Physics
Nature Physics, 2017, 13 (9), pp.906-913. ⟨10.1038/NPHYS4138⟩
Nature Physics, Nature Publishing Group, 2017, 13 (9), pp.906-913. ⟨10.1038/NPHYS4138⟩

The integrity of living tissues is maintained by adhesion domains of trans-bonds formed between cadherin proteins residing on opposing membranes of neighbouring cells. These domains are stabilized by lateral cis-interactions between the cadherins on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf095a3df5deda05b77b9a13a1167140
https://hdl.handle.net/2128/15921

Association Rates of Membrane-Coupled Cell Adhesion Molecules

Autor: Ana-Sunčana Smith, Kheya Sengupta, Udo Seifert, Timo Bihr, Susanne F. Fenz, Rudolf Merkel, Erich Sackmann

Publikováno v: Biophysical Journal. 107(11):L33-L36

Thus far, understanding how the confined cellular environment affects the lifetime of bonds, as well as the extraction of complexation rates, has been a major challenge in studies of cell adhesion. Based on a theoretical description of the growth cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6411942d0d6a0a068f73abf0d43a5b19

Multiscale approaches to protein-mediated interactions between membranes - Relating microscopic and macroscopic dynamics in radially growing adhesions

Autor: Udo Seifert, Ana-Sunčana Smith, Timo Bihr

Publikováno v: New Journal of Physics

Macromolecular complexation leading to coupling of two or more cellular membranes is a crucial step in a number of biological functions of the cell. While other mechanisms may also play a role, adhesion always involves the fluctuations of deformable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c8a2fa4d37693f77441f2ece99aae1
http://arxiv.org/abs/1503.01718

Nucleation of ligand-receptor domains in membrane adhesion

Autor: Timo Bihr, Ana-Sunčana Smith, Udo Seifert

Publikováno v: Physical review letters. 109(25)

We present a comprehensive model for the nucleation of domains in membrane adhesion. We determine the critical number of bonds in a nucleus and calculate the probability distribution of nucleation time from a discrete master equation. The latter is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5872af06be04599dad6b9c4ab4b664
https://pubmed.ncbi.nlm.nih.gov/23368503