Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Timo Stellfeld"'
Autor:
Lilia Falkenstern, Victoria Georgi, Stefanie Bunse, Volker Badock, Manfred Husemann, Ulrike Roehn, Timo Stellfeld, Mark Fitzgerald, Steven Ferrara, Detlef Stöckigt, Carlo Stresemann, Ingo V. Hartung, Amaury Fernández-Montalván
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract The market approval of Tazemetostat (TAZVERIK) for the treatment of follicular lymphoma and epithelioid sarcoma has established “enhancer of zeste homolog 2” (EZH2) as therapeutic target in oncology. Despite their structural similarities
Externí odkaz:
https://doaj.org/article/86f7032f806147479748eda7c74b8341
Autor:
Douglas L, Orsi, Elisabeth, Pook, Nico, Bräuer, Anders, Friberg, Philip, Lienau, Christopher T, Lemke, Timo, Stellfeld, Ulf, Brüggemeier, Vera, Pütter, Hanna, Meyer, Maria, Baco, Stephanie, Tang, Andrew D, Cherniack, Lindsay, Westlake, Samantha A, Bender, Mustafa, Kocak, Craig A, Strathdee, Matthew, Meyerson, Knut, Eis, Jonathan T, Goldstein
Publikováno v:
Journal of medicinal chemistry. 65(21)
The ligand-activated nuclear receptor peroxisome-proliferator-activated receptor-γ (PPARG or PPARγ) represents a potential target for a new generation of cancer therapeutics, especially in muscle-invasive luminal bladder cancer where PPARγ is a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae813451ab4026cd308dc1142c4ed2b6
https://pubmed.ncbi.nlm.nih.gov/36542814
https://pubmed.ncbi.nlm.nih.gov/36542814
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Autor:
Douglas L. Orsi, Elisabeth Pook, Nico Bräuer, Anders Friberg, Philip Lienau, Christopher T. Lemke, Timo Stellfeld, Ulf Brüggemeier, Vera Pütter, Hanna Meyer, Maria Baco, Stephanie Tang, Andrew D. Cherniack, Lindsay Westlake, Samantha A. Bender, Mustafa Kocak, Craig A. Strathdee, Matthew Meyerson, Knut Eis, Jonathan T. Goldstein
Publikováno v:
Journal of Medicinal Chemistry. 65:14843-14863
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcec82278b2a513b7653d5a4ef4822cb
https://doi.org/10.1021/acs.jmedchem.2c01379
https://doi.org/10.1021/acs.jmedchem.2c01379
Autor:
Douglas L. Orsi, Steven J. Ferrara, Stephan Siegel, Anders Friberg, Léa Bouché, Elisabeth Pook, Philip Lienau, Joseph P. Bluck, Christopher T. Lemke, Gizem Akcay, Timo Stellfeld, Hanna Meyer, Vera Pütter, Simon J. Holton, Daniel Korr, Isabel Jerchel-Furau, Constantia Pantelidou, Craig A. Strathdee, Matthew Meyerson, Knut Eis, Jonathan T. Goldstein
Publikováno v:
Bioorganic & medicinal chemistry 78, 117130 (2023). doi:10.1016/j.bmc.2022.117130
Bioorganic & medicinal chemistry 78, 117130 (2023). doi:10.1016/j.bmc.2022.117130
PPAR gamma (PPARG) is a ligand activated transcription factor that regulates genes involved in inflammation, bone biology, lipid homeostasis, as well as a master r
PPAR gamma (PPARG) is a ligand activated transcription factor that regulates genes involved in inflammation, bone biology, lipid homeostasis, as well as a master r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8a065063af626237bd6ead93ee15d7
https://bib-pubdb1.desy.de/record/491342
https://bib-pubdb1.desy.de/record/491342
Autor:
Tobias Thaler, Elisabeth Kersten, Hannah JÖRIßEN, Chantal Fürstner, Sonja Anlauf, Mark Meininghaus, Kersten Matthias Gericke, Lisa Dietz, Dirk Schneider, Hartmut Beck, Virginia Marossek, Carsten Terjung, Johanna Anlahr, Daniel Meibom, Uwe Münster, Thomas Buyck, Raimund Kast, Kai Lovis, Timo Stellfeld, Guillaume Levilain, Michaela Bairlein, Clemens-Jeremias Von Bühler
Publikováno v:
Journal of Medicinal Chemistry. 63:11639-11662
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3bcb4904153e431b637e901e8f4428
https://doi.org/10.1021/acs.jmedchem.0c00834
https://doi.org/10.1021/acs.jmedchem.0c00834
Autor:
Douglas L. Orsi, Elisabeth Pook, Nico Bräuer, Anders Friberg, Philip Lienau, Christopher T. Lemke, Timo Stellfeld, Ulf Brüggemeier, Vera Pütter, Hanna Meyer, Maria Baco, Stephanie Tang, Andrew D. Cherniack, Lindsay Westlake, Samantha A. Bender, Mustafa Kocak, Craig A. Strathdee, Matthew Meyerson, Knut Eis, Jonathan T. Goldstein
Publikováno v:
Journal of Medicinal Chemistry. 66:1082-1082
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4cea163f1d6c31ece521e358ffd5a2
https://doi.org/10.1021/acs.jmedchem.2c02002
https://doi.org/10.1021/acs.jmedchem.2c02002
Autor:
Claudia Merz, Marcus Bauser, Martin Michels, Ashley Eheim, David T. Scadden, Henrik Seidel, Ralf Lesche, Timo Stellfeld, Hanna Meyer, Pascale Lejeune, Thomas Mueller, Detlef Stoeckigt, David B. Sykes, Steven James Ferrara, Sven Christian, Andrea Haegebarth, Judith Guenther, Andreas Janzer, Katja Zimmermann, Sherif El Sheikh, Stefan Gradl, Michael Bruening
Publikováno v:
Cancer Research. 78:DDT02-04
Acute myeloid leukemia (AML), the most common acute leukemia in adults, is an aggressive hematologic malignancy resulting in bone marrow failure with a poor outcome; overall survival is approximately 25% at five years. Treatment options, in particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810e228e308047a51f2ef7b9122f3063
https://doi.org/10.1158/1538-7445.am2018-ddt02-04
https://doi.org/10.1158/1538-7445.am2018-ddt02-04
Autor:
Cheryl H. Arrowsmith, Cora Scholten, Léa Bouché, Masoud Vedadi, Mathew Sutherland, Ingo Hartung, Alice Li, Vijayaratnam Santhakumar, Dimitrios Panagopoulos, Magdalena M. Szewczyk, Fengling Li, Robert Britton, Timo Stellfeld, Holger Steuber, Dalia Barsyte, David Smil, Anissa Kaghad
Publikováno v:
ChemMedChem 16(7), 1116-1125 (2021). doi:10.1002/cmdc.202100018
ChemMedChem 16(7), 1116 - 1125 (2021). doi:10.1002/cmdc.202100018
Protein arginine N-methyl transferase 4 (PRMT4) asymmetricallydimethylates the arginine residues of histone H3 and nonhistoneproteins. The overexpression of PRMT4 in several cance
Protein arginine N-methyl transferase 4 (PRMT4) asymmetricallydimethylates the arginine residues of histone H3 and nonhistoneproteins. The overexpression of PRMT4 in several cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59892e7b4f1f6e1fd9df5173926932c
https://doi.org/10.1101/2020.11.17.387233
https://doi.org/10.1101/2020.11.17.387233
Autor:
Katja Zimmermann, Henrik Seidel, Vera Puetter, Sherif El Sheikh, Steven James Ferrara, Stefan Gradl, Claudia Merz, Anders Friberg, Sven Christian, Andrea Haegebarth, Thomas Mueller, Ashley Eheim, Timo Stellfeld, David T. Scadden, Marcus Bauser, Duy Nguyen, Michael Niehues, Martina Schaefer, Michael Bruening, Martin Michels, Judith Guenther, Knut Eis, Detlef Stoeckigt, Hanna Meyer, Pascal Lejeune, Andreas Janzer, Han-Jie Zhou, David B. Sykes, Michael Kroeber
Publikováno v:
Cancer Research. 79:2-2
DHODH is a key enzyme in the biosynthesis of pyrimidines and recent studies have renewed interest in this old anti-cancer target. Here, we disclose the discovery of 4-triazolosalicylamides as inhibitors of DHODH and their structure activity relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6ee917949e8111944b8c7f5491d2229
https://doi.org/10.1158/1538-7445.am2019-2
https://doi.org/10.1158/1538-7445.am2019-2
Autor:
Ludger Dinkelborg, Roger Schibli, Markus Reiher, Timo Stellfeld, Carmen J. Müller, Stefanie D. Krämer, Svetlana V. Selivanova, Simon M. Ametamey, Keith Graham, Lukas O. Dialer, Adrienne Müller
Publikováno v:
Journal of Medicinal Chemistry. 56:7552-7563
Silicon-containing prosthetic groups have been conjugated to peptides to allow for a single-step labeling with (18)F radioisotope. The fairly lipophilic di-tert-butylphenylsilane building block contributes unfavorably to the pharmacokinetic profile o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14987e3eb91210e89a3a62b4dac37df6
https://doi.org/10.1021/jm400857f
https://doi.org/10.1021/jm400857f