An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons.

Autor: Avarlaid A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia. Electronic address: annela.avarlaid@taltech.ee., Falkenberg K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Lehe K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Mudò G; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Belluardo N; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Di Liberto V; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Frinchi M; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Protobios LLC, Tallinn, Estonia., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Protobios LLC, Tallinn, Estonia. Electronic address: tonis.timmusk@taltech.ee.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Jun; Vol. 300 (6), pp. 107411. Date of Electronic Publication: 2024 May 23.

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience.

Autor: Kumar A; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA., Karuppagounder SS; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA., Chen Y; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA., Corona C; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA., Kawaguchi R; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Cheng Y; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Balkaya M; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA., Sagdullaev BT; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA; Regeneron Pharmaceuticals, Tarrytown, New York, NY, USA., Wen Z; Departments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurology, Emory University School of Medicine, Atlanta, GA, USA., Stuart C; East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA., Cho S; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA., Ming GL; Department of Neuroscience, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Ratan RR; Burke Neurological Institute and Brain and Mind Research Institute, Weill Cornell Medicine, 785 Mamaroneck Ave, White Plains, NY, USA. Electronic address: rrr2001@med.cornell.edu.

Publikováno v: Neuron [Neuron] 2023 Sep 20; Vol. 111 (18), pp. 2831-2846.e10. Date of Electronic Publication: 2023 Jul 14.

Revisiting the expression of BDNF and its receptors in mammalian development.

Autor: Esvald EE; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia.; dxlabs LLC, Tallinn, Estonia., Kiir CS; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Avarlaid A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Tamberg L; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Sirp A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Shubina A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Cabrera-Cabrera F; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Pihlak A; Protobios LLC, Tallinn, Estonia., Koppel I; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Palm K; Protobios LLC, Tallinn, Estonia., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2023 Jun 22; Vol. 16, pp. 1182499. Date of Electronic Publication: 2023 Jun 22 (Print Publication: 2023).

PCSK9 deficiency alters brain lipid composition without affecting brain development and function.

Autor: Pärn A; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Olsen D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia., Kaas M; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Borisova E; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics, Tomsk, Russia., Bilgin M; Danish Cancer Society Research Center, Lipidomics Core Facility, Copenhagen, Denmark., Elhauge M; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Vilstrup J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Draupnir Bio ApS, INCUBA Skejby, Aarhus, Denmark., Madsen P; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Draupnir Bio ApS, INCUBA Skejby, Aarhus, Denmark., Ambrozkiewicz MC; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Goz RU; Department of Neurobiology, University of Pittsburgh Medical School, Pittsburgh, PA, United States., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia., Tarabykin V; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics, Tomsk, Russia., Gustafsen C; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Draupnir Bio ApS, INCUBA Skejby, Aarhus, Denmark., Glerup S; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Draupnir Bio ApS, INCUBA Skejby, Aarhus, Denmark.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2023 Jan 17; Vol. 15, pp. 1084633. Date of Electronic Publication: 2023 Jan 17 (Print Publication: 2022).

Expression of alternative transcription factor 4 mRNAs and protein isoforms in the developing and adult rodent and human tissues.

Autor: Sirp A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Shubina A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia., Tamberg L; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Kiir CS; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Kranich L; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Protobios LLC, Tallinn, Estonia.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Nov 02; Vol. 15, pp. 1033224. Date of Electronic Publication: 2022 Nov 02 (Print Publication: 2022).