A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer

Autor: Wester, L., Venneker, S., Hazenoot, M., Pont, C.M., Koedoot, E., Timmermans, A.M., Martens, J.W.M., Jansen, M.P.H.M., Kockx, C.E.M., IJcken, W.F.J. van, Meerman, J.H.N., Zhang, Y., Water, B. van de

Publikováno v: Biochemical Pharmacology, 204:115233
Biochemical Pharmacology, 204:115233. Elsevier Inc.

Antiestrogen resistance of breast cancer has been related to enhanced growth factor receptor expression and activation. We have previously shown that ectopic expression and subsequent activation of the insulin-like growth factor-1 receptor (IGF1R) or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831ab25ab2a95dcef5e324037a6f2ef2
http://hdl.handle.net/1887/3492042

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Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

Autor: Marchi, T. De, Timmermans, A.M., Smid, M., Look, M.P., Stingl, C., Opdam, M., Linn, S.C., Sweep, C.G.J., Span, P.N., Kliffen, M., Deurzen, C.H. van, Luider, T.M., Foekens, J.A., Martens, J.W., Umar, A., Albers, E.M.

Publikováno v: ResearcherID
Oncotarget, 7, 3, pp. 3098-3110
Oncotarget
Oncotarget, 7, 3098-3110
Oncotarget, 7(3), 3098. Impact Journals

Tamoxifen therapy resistance constitutes a major cause of death in patients with recurrent estrogen receptor (ER) positive breast cancer. Through high resolution mass spectrometry (MS), we previously generated a 4-protein predictive signature for tam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a306cdaca012f11211373754d3cfc8c9
https://doi.org/10.18632/oncotarget.6521

Four Hypotheses to Explain Axillary Budbreak after Removal of Flower Shoots in a Cut-rose Crop

Autor: Wubs-Timmermans, A.M., Heuvelink, E., Marcelis, L.F.M., Okello, R.C., Buck-Sorlin, G.H., Vos, J.

Publikováno v: Journal of the American Society for Horticultural Science 138 (2013) 4
Journal of the American Society for Horticultural Science, 138(4), 243-252

When flower-bearing shoots in cut-rose (Rosa ×hybrida) are harvested (removed), a varying number of repressed axillary buds on the shoot remainder start to grow into new shoots (budbreak). Besides removing within-shoot correlative inhibition, it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bee0dcbcc481c560e7b42f350d29b05b
https://research.wur.nl/en/publications/four-hypotheses-to-explain-axillary-budbreak-after-removal-of-flo

198P - The prevalence of CD146 expression in breast cancer subtypes and its relation to outcome

Autor: de Kruijff, I.E. ¹, Timmermans, A.M. ¹, den Bakker, M.A. ², Trapman, A.M.A.C. ¹, Foekens, R. ¹, Oomen-De Hoop, E. ¹, Smid, M. ¹, Fat - Hollestelle, A. ¹, van Deurzen, C.H.M. ², Meijer - van Gelder, M.E. ¹, Foekens, J.A. ¹, Martens, J.W.M. ¹, Sleijfer, S. ¹, Tjon, A.

Publikováno v: In Annals of Oncology September 2017 28 Supplement 5:v61-v61