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The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.

Autor: Munro, G, Hansen, RR, Erichsen, HK, Timmermann, DB, Christensen, JK, Hansen, HH

Publikováno v: British Journal of Pharmacology; Sep2012, Vol. 167 Issue 2, p421-435, 15p, 3 Charts, 6 Graphs

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Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.

Autor: Sourris KC; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia; Diabetes Complications Division, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia. Electronic address: Karly.Sourris@monash.edu., Ding Y; Diabetes Complications Division, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia; Diabetes Complications Research, Novo Nordisk, Måløv, Denmark., Maxwell SS; Epigenetics in Human Health and Disease Program, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia., Al-Sharea A; Haematopoiesis and Leukocyte Biology, Division of Immunometabolism, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia., Kantharidis P; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia., Mohan M; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia., Rosado CJ; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia., Penfold SA; Diabetes Complications Division, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia., Haase C; Diabetes Complications Research, Novo Nordisk, Måløv, Denmark., Xu Y; Haematopoiesis and Leukocyte Biology, Division of Immunometabolism, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia., Forbes JM; Mater Research Institute, the University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia., Crawford S; Monash Ramaciotti Centre for Cryo Electron Microscopy, Monash University, Clayton, Victoria, Australia., Ramm G; Monash Ramaciotti Centre for Cryo Electron Microscopy, Monash University, Clayton, Victoria, Australia., Harcourt BE; Murdoch Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia., Jandeleit-Dahm K; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia., Advani A; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michaels Hospital, Toronto, Ontario, Canada., Murphy AJ; Haematopoiesis and Leukocyte Biology, Division of Immunometabolism, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia., Timmermann DB; Novo Nordisk, Copenhagen, Denmark., Karihaloo A; Novo Nordisk Research Center Seattle, Inc., Seattle, Washington, USA., Knudsen LB; Novo Nordisk, Copenhagen, Denmark., El-Osta A; Epigenetics in Human Health and Disease Program, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia., Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Cooper ME; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia., Coughlan MT; Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Victoria, Australia; Diabetes Complications Division, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, Parkville, Victoria, Australia. Electronic address: melinda.coughlan@monash.edu.

Publikováno v: Kidney international [Kidney Int] 2024 Jan; Vol. 105 (1), pp. 132-149. Date of Electronic Publication: 2023 Dec 08.