Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies.

Autor: Wang E; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada., Belley-Côté EP; Departments of Medicine (Cardiology and Critical Care), McMaster University, Hamilton, ON, Canada; Perioperative Research Division, Population Health Research Institute, Hamilton, ON, Canada., Young J; Health Sciences Library, McMaster University, Hamilton, ON, Canada., He H; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada., Saud H; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada., D'Aragon F; Départment d'anesthésiologie, Université de Sherbrooke, Quebec, QU, Canada., Um K; Department of Medicine, McMaster University, Hamilton, ON, Canada., Alhazzani W; Departments of Critical Care, Medicine (Gastroenterology), and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada., Piticaru J; Department of Medicine, McMaster University, Hamilton, ON, Canada., Hedden M; Faculty of Arts and Science, Queen's University, Kingston, ON, Canada., Whitlock R; Perioperative Research Division, Population Health Research Institute, Hamilton, ON, Canada; Departments of Surgery (Cardiac Surgery) and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada., Mazer CD; Department of Anesthesia and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada., Kashani HH; Department of Anesthesia and Perioperative Medicine, University of Manitoba, Winnipeg, MB, Canada., Zhang SY; Faculty of Medicine, McGill University, Montreal, QU, Canada., Lucas A; Department of Health Research Methods, Evaluation, and Impact; McMaster University, Hamilton, ON, Canada., Timmerman N; Department of Anesthesia, McMaster University, Hamilton, ON, Canada., Nishi C; Department of Anesthesia, McMaster University, Hamilton, ON, Canada., Jain D; Department of Anesthesiology, Trillium Health Partners, Toronto, ON, Canada., Kugler A; Department of Anesthesia, McMaster University, Hamilton, ON, Canada., Beaver C; Sheridan College, Oakville, ON, Canada., Kloppenburg S; Organon, Montreal, QU, Canada., Schulman S; Department of Medicine (Hematology), McMaster University, Hamilton, ON, Canada; Thrombosis and Atherosclerosis Research Institute, Population Health Research Institute, Hamilton, ON, Canada; Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Borges FK; Perioperative Research Division, Population Health Research Institute, Hamilton, ON, Canada; Departments of Medicine and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada., Kavosh M; Department of Medicine, Coney Island Hospital, Brooklyn, NY, USA., Wada C; Faculty of Arts, Waseda University, Tokyo, Japan., Lin S; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada., Sibilio S; Division of Cardiac Surgery, Instituto Clinico Sant'Ambrogio, Milan, Italy; Division of Cardiac Surgery, Centre Hospitalière Universitaire de Lille, Lille, France., Lauw M; Population Health Research Institute, Hamilton, ON, Canada., Benz A; Population Health Research Institute, Hamilton, ON, Canada., Szczeklik W; Center for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland., Mokhtari A; Department of Medicine (Cardiology), McMaster University, Hamilton, ON, Canada., Jacobsohn E; Departments of Anesthesia and Perioperative Medicine and Medicine (Critical Care), University of Manitoba, Winnipeg, MB, Canada., Spence J; Perioperative Research Division, Population Health Research Institute, Hamilton, ON, Canada; Departments of Anesthesia and Critical Care and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada. Electronic address: spencej@phri.ca.

Publikováno v: British journal of anaesthesia [Br J Anaesth] 2023 Aug; Vol. 131 (2), pp. 302-313. Date of Electronic Publication: 2023 Jan 06.

Plasma Extracellular Vesicle Serpin G1 and CD14 Levels are Associated with Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients Undergoing Femoral Endarterectomy.

Autor: Verwer MC; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Mekke JM; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Timmerman N; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Van Der Pol QY; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Frissen C; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Pasterkamp G; Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands., De Borst GJ; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Hazenberg CEVB; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., De Kleijn DPV; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: dkleijn@umcutrecht.nl.

Publikováno v: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2023 Feb; Vol. 65 (2), pp. 282-290. Date of Electronic Publication: 2022 Nov 02.

Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.

Autor: Mokry M; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Boltjes A; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Slenders L; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Bel-Bordes G; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Cui K; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Brouwer E; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Mekke JM; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Depuydt MAC; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands., Timmerman N; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Waissi F; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Verwer MC; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Turner AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Khan MD; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Hodonsky CJ; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Benavente ED; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Hartman RJG; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., van den Dungen NAM; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Lansu N; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Nagyova E; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Prange KHM; Amsterdam University Medical Centers - location AMC, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, The Netherlands., Kovacic JC; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Victor Chang Cardiac Research Institute, Darlinghurst, Australia; and St Vincent's Clinical School, University of New South Wales, Australia., Björkegren JLM; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA., Pavlos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Andreakos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Schunkert H; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, Munich, Germany., Owens GK; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Monaco C; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford., Finn AV; CVPath Institute, Inc, Gaithersburg, MD, USA., Virmani R; CVPath Institute, Inc, Gaithersburg, MD, USA., Leeper NJ; Department of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA., de Winther MPJ; Amsterdam University Medical Centers - location AMC, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, The Netherlands., Kuiper J; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands., de Borst GJ; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Stroes ESG; Department of Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands., Civelek M; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., de Kleijn DPV; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., den Ruijter HM; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Asselbergs FW; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom., van der Laan SW; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Miller CL; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Biomedical Engineering, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Pasterkamp G; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Dec; Vol. 1 (12), pp. 1140-1155. Date of Electronic Publication: 2022 Dec 12.

Targeted proteomics improves cardiovascular risk prediction in secondary prevention.

Autor: Nurmohamed NS; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; Department of Cardiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Belo Pereira JP; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Hoogeveen RM; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Kroon J; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Kraaijenhof JM; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Waissi F; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Timmerman N; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Bom MJ; Department of Cardiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Hoefer IE; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Knaapen P; Department of Cardiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Catapano AL; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy.; IRCCS Multimedica, Milano, Italy., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Visseren FLJ; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Levin E; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; HorAIzon BV, Delft, The Netherlands., Stroes ESG; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Publikováno v: European heart journal [Eur Heart J] 2022 Apr 19; Vol. 43 (16), pp. 1569-1577.

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis.

Autor: Slenders L; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Landsmeer LPL; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Cui K; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Depuydt MAC; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Verwer M; Department of Vascular Surgery, University Medical Centre Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Mekke J; Department of Vascular Surgery, University Medical Centre Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Timmerman N; Department of Vascular Surgery, University Medical Centre Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., van den Dungen NAM; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Kuiper J; Department of Medical Biochemistry, Amsterdam University Medical Centers-Location AMC, University of Amsterdam, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam, The Netherlands., de Winther MPJ; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Prange KHM; Department of Medical Biochemistry, Amsterdam University Medical Centers-Location AMC, University of Amsterdam, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam, The Netherlands., Ma WF; Medical Scientist Training Program, University of Virginia, 200 Jeanette Lancaster Way, Charlottesville, VA 22908, USA.; Center for Public Health Genomics, University of Virginia, West Complex, 1335 Lee St, Charlottesville, VA 22908, USA., Miller CL; Center for Public Health Genomics, University of Virginia, West Complex, 1335 Lee St, Charlottesville, VA 22908, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, 1340 Jefferson Rark Avenue, Charlottesville, VA 22908, USA.; Department of Public Health Sciences, University of Virginia, West Complex Rm 3181, Charlottesville, VA 22908, USA., Aherrahrou R; Center for Public Health Genomics, University of Virginia, West Complex, 1335 Lee St, Charlottesville, VA 22908, USA., Civelek M; Center for Public Health Genomics, University of Virginia, West Complex, 1335 Lee St, Charlottesville, VA 22908, USA.; Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA., de Borst GJ; Department of Vascular Surgery, University Medical Centre Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., de Kleijn DPV; Department of Vascular Surgery, University Medical Centre Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Asselbergs FW; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands., den Ruijter HM; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands., Boltjes A; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands., Mokry M; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands.

Publikováno v: European heart journal open [Eur Heart J Open] 2021 Dec 21; Vol. 2 (1), pp. oeab043. Date of Electronic Publication: 2021 Dec 21 (Print Publication: 2022).