BTK inhibitor-induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α.

Autor: Vargas-Blanco DA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Hepworth OW; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Basham KJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Simaku P; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Crossen AJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Timmer KD; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Hopke A; Harvard Medical School, Boston, Massachusetts, USA.; BioMEMS Resource Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Shriners Hospital for Children, Boston, Massachusetts, USA., Brown Harding H; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Vandal SR; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Jensen KN; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Floyd DJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Reedy JL; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Reardon C; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mansour MK; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Ward RA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Irimia D; Harvard Medical School, Boston, Massachusetts, USA.; BioMEMS Resource Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Shriners Hospital for Children, Boston, Massachusetts, USA., Abramson JS; Center for Lymphoma, Mass General Cancer Center, Boston, Massachusetts, USA., Vyas JM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: JCI insight [JCI Insight] 2024 May 07; Vol. 9 (12). Date of Electronic Publication: 2024 May 07.

The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan.

Autor: Reedy JL; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Department of Medicine, Boston, Massachusetts, USA., Crossen AJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Negoro PE; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Harding HB; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ward RA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Vargas-Blanco DA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Timmer KD; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Reardon CM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Basham KJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mansour MK; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Department of Medicine, Boston, Massachusetts, USA., Wüthrich M; Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA., Fontaine T; Institut Pasteur, Université de Paris, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques, Paris, France., Latgé JP; Institute of Molecular Biology and Biotechnology (IMBBFORTH), University of Crete, Heraklion, Greece., Vyas JM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Department of Medicine, Boston, Massachusetts, USA.

Publikováno v: MBio [mBio] 2023 Feb 28; Vol. 14 (1), pp. e0318422. Date of Electronic Publication: 2023 Jan 04.

Transcellular biosynthesis of leukotriene B 4 orchestrates neutrophil swarming to fungi.

Autor: Hopke A; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA 02129, USA.; Harvard Medical School, Boston, MA 02115, USA.; Shriners Hospital for Children, Boston, MA 02114, USA., Lin T; Harvard Medical School, Boston, MA 02115, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA., Scherer AK; Harvard Medical School, Boston, MA 02115, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Shay AE; Harvard Medical School, Boston, MA 02115, USA.; Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Timmer KD; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Wilson-Mifsud B; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA., Mansour MK; Harvard Medical School, Boston, MA 02115, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Serhan CN; Harvard Medical School, Boston, MA 02115, USA.; Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Irimia D; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA 02129, USA.; Harvard Medical School, Boston, MA 02115, USA.; Shriners Hospital for Children, Boston, MA 02114, USA., Hurley BP; Harvard Medical School, Boston, MA 02115, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.

Publikováno v: IScience [iScience] 2022 Sep 28; Vol. 25 (10), pp. 105226. Date of Electronic Publication: 2022 Sep 28 (Print Publication: 2022).

Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in COVID-19: A case-control study.

Autor: Atallah NJ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Warren HM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America., Roberts MB; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Elshaboury RH; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, United States of America., Bidell MR; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, United States of America., Gandhi RG; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, United States of America., Adamsick M; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, United States of America., Ibrahim MK; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Sood R; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Bou Zein Eddine S; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Department of Surgery, Massachusetts General Hospital, Boston, MA, United States of America., Cobler-Lichter MJ; Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States of America., Alexander NJ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America., Timmer KD; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America., Atallah CJ; Faculty of Medicine, University of Balamand, Beirut, Lebanon., Viens AL; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America., Panossian VS; Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon., Scherer AK; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Proctor T; Fisher Diagnostics, Part of Thermo Fisher Scientific, Middletown, VA, United States of America., Smartt S; Fisher Diagnostics, Part of Thermo Fisher Scientific, Middletown, VA, United States of America., Letourneau AR; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Paras ML; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America., Johannes S; B·R·A·H·M·S GmbH, Part of Thermo Fisher Scientific, Hennigsdorf, Germany., Wiemer J; B·R·A·H·M·S GmbH, Part of Thermo Fisher Scientific, Hennigsdorf, Germany., Mansour MK; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America.

Publikováno v: PloS one [PLoS One] 2022 Jan 13; Vol. 17 (1), pp. e0262342. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2022).