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Autor:
Timmer, John C.
Publikováno v:
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Thesis (Ph. D.)--University of California, San Diego, 2009.
Title from first page of PDF file (viewed Aug. 10, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 125-128).
Title from first page of PDF file (viewed Aug. 10, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 125-128).
Externí odkaz:
http://wwwlib.umi.com/cr/ucsd/fullcit?p3360418
Akademický článek
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Autor:
Angelica Sanabria, Heather Kinkead, Rajay Pandit, Florian Sulzmaier, Chelsie Macedo, Sae Jeong Ahn, Brendan P. Eckelman, Crago William, Anya Polovina, Nadja Kern, Timmer John C, Abrahim Hussain, Analeah Heidt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundNatural Killer (NK) cells play a pivotal role in cancer immunosurveillance due to their potent cytolytic activity and NK cell-centric therapies have emerged as safer alternatives to targeting T cells.1 2 Interleukin 2 (IL-2) drives NK cell
Autor:
Mahan Abbasian, Heather K Raymon, Hardik Modi, Rama K. Narla, Quinn Deveraux, Dan Zhu, Brendan P. Eckelman, Laure Escoubet, Lilly Wong, Stephan J Kopytek, Timmer John C, Joseph R Piccotti, Daniel Bauer, Kandasamy Hariharan, Jim Leisten
Publikováno v:
Cancer immunology, immunotherapy : CII. 71(2)
Cluster of differentiation 47 (CD47) is a transmembrane protein ubiquitously expressed on human cells but overexpressed on many different tumor cells. The interaction of CD47 with signal-regulatory protein alpha (SIRPα) triggers a “don’t eat me
Autor:
Danielle Montt, Rachael Logan, Timmer John C, Mark Pogson, Jordan Jarjour, Claudya Evandy, Jones Kyle S, Giacomo Tampella, Quennie Vong, Anne-Rachael Krostag, Joshua A. Gustafson, Dong Xia, Alexander Astrakhan, Kaori Oda, Bryan Peguero, Wai-Hang Leung, Jacob Appelbaum, Brendan Eckelman, Joy Zhang, Michael C. Jensen, James B. Rottman, Unja Martin
Publikováno v:
Regular and young investigator award abstracts.
Background Bioengineered T cell treatments for acute myeloid leukemia (AML) are challenged by near universal expression of leukemia antigens on normal hematopoietic stem/progenitor cells:1 2 ‘on target/off tumor‘ activity may cause myelosuppressi
Autor:
James Kalabus, Garrett Cyprus, Florian Sulzmaier, Brendan P. Eckelman, Heather Kinkead, Quinn Deveraux, Timmer John C, Chelsie Macedo, Analeah Heidt, Bryan Becklund, Rajay Pandit, Angelica Sanabria
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Background4-1BB is a costimulatory molecule that is predominantly expressed on activated CD8+ T cells and is induced upon T cell receptor mediated activation.1 Within the tumor microenvironment, 4-1BB-expressing T cells are enriched for anti-tumor re
Autor:
Timmer, John C.1,2, Zhu, Wenhong1, Pop, Cristina1, Regan, Tim3, Snipas, Scott J.1, Eroshkin, Alexey M.1, Riedl, Stefan J.1, Salvesen, Guy S.1,2 gsalvesen@burnham.org
Publikováno v:
Nature Structural & Molecular Biology. Oct2009, Vol. 16 Issue 10, p1101-1108. 8p. 2 Diagrams, 1 Chart, 6 Graphs.
Autor:
Denise Gonzalez, Amanda Chen, Nebiyu Wondyfraw, Mikayel Mkrtichyan, Quinn Deveraux, Susannah D. Barbee, David I. Bellovin, Jones Kyle S, Timmer John C, Luis Borges, S.E. Johnson, Chelsie Hata, Brendan P. Eckelman, Amir S. Razai
Publikováno v:
Cancer Research. 77:613-613
Glucocorticoid-induced TNFR-related (GITR, TNFRSF18) is a member of the TNFR superfamily with pleiotropic T cell modulatory activity. We are developing a novel anti-GITR antibody with enhanced agonist activity for the treatment of solid tumors. Our c
Akademický článek
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Autor:
Uchiyama, Satoshi, Döhrmann, Simon, Timmer, Anjuli M., Dixit, Neha, Ghochani, Mariam, Bhandari, Tamara, Timmer, John C., Sprague, Kimberly, Bubeck-Wardenburg, Juliane, Simon, Scott I., Nizet, Victor, Alonzo, Francis, Beres, Stephen B.
Publikováno v:
Frontiers in Immunology; 11/1/2016, Vol. 6/7, p1-10, 10p