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pro vyhledávání: '"Timm Tanzeglock"'
Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor
Autor:
Hervé Broly, Robin A. Sorg, Timm Tanzeglock, Massimo Morbidelli, Arnaud Périlleux, Miroslav Soos, Thomas Solacroup
Publikováno v:
Biotechnology Journal. 6:1504-1515
The objective of the present study was to investigate the effect of hydrodynamic stress heterogeneity on metabolism and productivity of an industrial mammalian cell line. For this purpose, a novel Lobed Taylor-Couette (LTC) mixing unit combining a na
Publikováno v:
Biotechnology and Bioengineering. 104:360-370
In this work we investigated whether the type of shear flow, to which cells are exposed, influences the initiation of cell death. It is shown that mammalian cells, indeed, distinguish between discrete types of flow and respond differently. Two flow d
Publikováno v:
New Biotechnology. 25:S190-S191