Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Timm Schroeder"'
Autor:
Geethika Arekatla, Stavroula Skylaki, David Corredor Suarez, Hartland Jackson, Denis Schapiro, Stefanie Engler, Markus Auler, German Camargo Ortega, Simon Hastreiter, Andreas Reimann, Dirk Loeffler, Bernd Bodenmiller, Timm Schroeder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pluripotent mouse embryonic stem cells (ESCs) can differentiate to all germ layers and serve as an in vitro model of embryonic development. To better understand the differentiation paths traversed by ESCs committing to different lineages, we
Externí odkaz:
https://doaj.org/article/b8a1252720554a2e99b83d10ecd90a0e
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/87dff8dad95949c58ab7392c757304f7
Autor:
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre PA Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus G Manz, Steffen Boettcher
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 445-474 (2024)
Abstract TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option f
Externí odkaz:
https://doaj.org/article/3995291a6c424aeaadea031a81b64f56
Autor:
Fabienne Gräbnitz, Dominique Stark, Danielle Shlesinger, Anthony Petkidis, Mariana Borsa, Alexander Yermanos, Andreas Carr, Niculò Barandun, Arne Wehling, Miroslav Balaz, Timm Schroeder, Annette Oxenius
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112468- (2023)
Summary: The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric cell division (ACD) as a safeguard mechanism for memory CD8 T c
Externí odkaz:
https://doaj.org/article/bcf275accd224424bf38dd9db79b0d8e
Autor:
Philip Dettinger, Tobias Kull, Geethika Arekatla, Nouraiz Ahmed, Yang Zhang, Florin Schneiter, Arne Wehling, Daniel Schirmacher, Shunsuke Kawamura, Dirk Loeffler, Timm Schroeder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Liquid handling and pipetting tools can automate repetitive tasks but are far from universally used. Here the authors report the Pipetting Helper Imaging Lid (PHIL), an open-source liquid handling robot designed for inexperienced users, that they use
Externí odkaz:
https://doaj.org/article/de59854a8b844e02bd342bc84f670d0b
Autor:
Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin
Publikováno v:
Haematologica, Vol 108, Iss 5 (2022)
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. Using three-dimensional fluorescence imaging of t
Externí odkaz:
https://doaj.org/article/92a284cf059b4741ba558a277a2f6d2a
Autor:
Oanh T. P. Nguyen, Patrick M. Misun, Christian Lohasz, Jihyun Lee, Weijia Wang, Timm Schroeder, Andreas Hierlemann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Existing first-line cancer therapies often fail to cope with the heterogeneity and complexity of cancers, so that new therapeutic approaches are urgently needed. Among novel alternative therapies, adoptive cell therapy (ACT) has emerged as a promisin
Externí odkaz:
https://doaj.org/article/2df92aee5c0b4e4c80dccfbb7889809f
Autor:
Elena Schaberg, Ursula Theocharidis, Marcus May, Katrin Lessmann, Timm Schroeder, Andreas Faissner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In the developing spinal cord neural stem and progenitor cells (NSPCs) secrete and are surrounded by extracellular matrix (ECM) molecules that influence their lineage decisions. The chondroitin sulfate proteoglycan (CSPG) DSD-1-PG is an isoform of re
Externí odkaz:
https://doaj.org/article/ef4cb12ad29e4bb0b97f51e6df81313a
Autor:
Paul E. Bourgine, Kristin Fritsch, Sebastien Pigeot, Hitoshi Takizawa, Leo Kunz, Konstantinos D. Kokkaliaris, Daniel L. Coutu, Markus G. Manz, Ivan Martin, Timm Schroeder
Publikováno v:
iScience, Vol 19, Iss , Pp 504-513 (2019)
Summary: The generation of humanized ectopic ossicles (hOss) in mice has been proposed as an advanced translational and fundamental model to study the human hematopoietic system. The approach relies on the presence of human bone marrow-derived mesenc
Externí odkaz:
https://doaj.org/article/39459b785a5d449c90b0a2fcc03f214e
Autor:
Ulrich Berge, Daria Bochenek, Ralf Schnabel, Arne Wehling, Timm Schroeder, Tanja Stadler, Ruth Kroschewski
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
We know that variations in cell cycle duration between cells naturally occur but the mechanisms are largely unknown. Here, using lineage tracking, hierarchical clustering and Monte Carlo methods, the authors show that large differences in granddaught
Externí odkaz:
https://doaj.org/article/d99e5c021b4647a79e4a74857f23b574