Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector.

Autor: Ellen S C Bushell, Andrea Ecker, Timm Schlegelmilch, David Goulding, Gordon Dougan, Robert E Sinden, George K Christophides, Fotis C Kafatos, Dina Vlachou

Publikováno v: PLoS Pathogens, Vol 5, Iss 8, p e1000539 (2009)

Malaria parasites must undergo sexual and sporogonic development in mosquitoes before they can infect their vertebrate hosts. We report the discovery and characterization of MISFIT, the first protein with paternal effect on the development of the rod

Externí odkaz: https://doaj.org/article/2f831be0a4194a9ea3b394ac3dedb1f0

Cell biological analysis of mosquito midgut invasion: the defensive role of the actin-based ookinete hood

Autor: Dina Vlachou, Timm Schlegelmilch

Publikováno v: Pathogens and Global Health

Successful completion of the Plasmodium lifecycle in the mosquito vector is critical for malaria transmission. It has been documented that the fate of Plasmodium in the mosquito ultimately depends on a fine interplay of molecular mosquito factors tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfc3d1777c6ac7ad0fc9bf3b570a03c
https://doi.org/10.1179/2047772413z.000000000180

Functional Genomic Analysis of Midgut Epithelial Responses in Anopheles during Plasmodium Invasion

Autor: George K. Christophides, Dina Vlachou, Fotis C. Kafatos, Timm Schlegelmilch

Publikováno v: Current Biology. 15:1185-1195

Summary Background: The malaria parasite Plasmodium must complete a complex developmental life cycle within Anopheles mosquitoes before it can be transmitted into the human host. One day after mosquito infection, motile ookinetes traverse the midgut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e086d606f75cbf100a7c09f205d68e0
https://doi.org/10.1016/j.cub.2005.06.044

Conserved Mosquito/Parasite Interactions Affect Development of Plasmodium falciparum in Africa

Autor: George K. Christophides, António M. Mendes, Anna Cohuet, Fotis C. Kafatos, Dina Vlachou, Isabelle Morlais, Didier Fontenille, Timm Schlegelmilch, Parfait Awono-Ambene, Maria De Iorio

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2008, 4 (5), pp.e1000069. ⟨10.1371/journal.ppat.1000069⟩
PLoS Pathogens, Vol 4, Iss 5, p e1000069 (2008)
PLoS Pathogens, 2008, 4 (5), pp.e1000069. ⟨10.1371/journal.ppat.1000069⟩

In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient laboratory studies have identified mosquito genes that affect positively or negatively the develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df9778b45907d459051a71462bd0eed
https://hal.ird.fr/ird-02897032